Cardiovascular Disease 2: Cellular And Molecular Mechanisms, Prevention, And Treatment Cardiovascular Disease Two Cardiovascular Disease Two

The Fourteenth Washington International Spring Symposium, held in Washington, D.C., in June 1994, brought together over 400 leading scientists from 21 countries to review and update research on cardiovascular disease. This group satisfied the symposium goals of formulating a more comprehensive and integrated picture of the events contributing to atherosclerosis and of exploring modified gene expression as an to understanding the causes of atherosclerosis and providing clues to the approach prevention and treatment. This volume contains most of the papers presented at the eight plenary sessions together with selected contributions from the special sessions. The multidisciplinary nature of the chapters and their authors should stimulate the interests of biochemists, cell and molecular biologists, pathologists, pharmacologists, epidemiologists, nutritionists, and clinicians. The volume is divided into eight sections which reflect the focus of the plenary sessions. Part I focuses on the pathophysiology of atherosclerotic plaques and predicts that the nature of the fibrous cap of atheroma determines plaque disruption and clinical events. Papers in Part II deal with atherogenic lipoproteins. The introductory paper reviews the current view of the role of plasma lipoproteins in atherosclerosis. With respect to the newer members on the list,: [oxidized LDL, Lp(a)] evidence is provided that suggests the involvement of one major gene in the development of oxidized LDL lipids. the expression of inflammatory genes, and the development of aortic fatty streaks. Front Matter....Pages i-xi Lipid Accumulation and Plaque Disruption: Processes Triggering Clinical Instability in Coronary Disease....Pages 1-9 Expression of 92 KDA Gelatinase in Human Atherosclerotic Lesions Following Recent Plaque Rupture....Pages 11-17 Proteinases and Restenosis: Matrix Metalloproteinase and their Inhibitor and Activator....Pages 19-30 Current Concepts of the Plasma Lipoproteins and Their Role in Atherosclerosis....Pages 31-40 Homeostasis of Lipid Oxidation in the Artery Wall....Pages 41-43 Molecular Basis for the Lysine Binding Polymorphism of Lipoprotein(a)....Pages 45-47 Triglyceride-Rich Lipoprotein Metabolism and Diabetes....Pages 49-55 Apolipoprotein E: Paradoxes Abound....Pages 57-66 The Role of Second Messenger Pathways in the Pathophysiology of Hyperapob and Premature Coronary Artery Disease....Pages 67-73 The Role of HDL Receptors in Removal of Cellular Cholesterol....Pages 75-78 The Defect in HDL 3 Mediated Efflux of Newly Synthesized Cholesterol is Associated with Impaired Activation of Protein Kinase C in Tangier Fibroblasts....Pages 79-87 Cholesterol Efflux from Cells in Culture: Studies with Lipid-Free Acceptors, Reconstituted Particles and Whole Serum....Pages 89-95 Apo A-I Containing Particles and Atherosclerosis....Pages 97-103 Vascular Endothelium: An Integrator of Pathophysiologic Stimuli in Cardiovascular Disease....Pages 105-107 Identification of FGF-1-Inducible Genes by Differential Display....Pages 109-120 Antioxidants and Endothelial Expression of Vcam-1: A Molecular Paradigm for Atherosclerosis....Pages 121-127 Mechanisms of Potentiation of Pdgf in Atherosclerosis....Pages 129-132 The Regulation of Normal and Pathological Angiogenesis by Vascular Endothelial Growth Factor....Pages 133-144 Developmentally Associated Gene Expression in Rabbit Vascular Smooth Muscle CeLLS....Pages 145-151 Molecular Basis and Pathologic Consequences of Neutrophil Adherence to Endothelium....Pages 153-157 The Distribution of Adhesion Molecules in Normal and Atherosclerotic Aarteries and Aortas....Pages 159-172 L-Selectin Regulation of Lymphocyte Homing and Leukocyte Rolling and Migration....Pages 173-184 L-Selectin, a Lectin-Like Receptor Involved in Normal Lymphocyte Recirculation and Inflammatory Leukocyte Trafficking....Pages 185-189 New Perspectives in P-Selectin Biology....Pages 191-197 Rat P-Selectin Mediates Neutrophil-Platelet Interactions Via two Sites (23–30, 76–90) Located on Its Lectin-Like Domain.....Pages 199-204 Regulation of Vascular Fibrinolysis by Type 1 Plasminogen Activator Inhibitor....Pages 205-209 Local Increase in Pai-2 on Stimulation of Monocytes with Modified Ldl....Pages 211-216 Structure, Function and Regulation of the Urokinase Receptor....Pages 217-221 Role of the Ldl Receptor-Related Protein in Proteinase and Lipoprotein Catabolism....Pages 223-233 Molecular Biology of Tf....Pages 235-247 Thrombin Receptor: Structure and Function....Pages 249-253 Antiplatelet Effects of Direct Acting Thrombin Inhibitors and Platelet Gpiib/Illa Antagonists: Comparative Analysis....Pages 255-267 Biosynthesis of Docosanoids by Human Platelet: Cardiovascular Properties....Pages 269-277 The Hemostatic Response to Arterial Injury in Vivo : Behavior of Prothrombin at the De-Endothelialised Aorta Wall....Pages 279-289 Plasma Coagulation Factors in Emergency Room Patients with Acute Chest Pain and Subsequent Hospitalization: Myocardial Infarction, Coronary Artery Disease, and Hypertension....Pages 291-298 Genetic Factors Contributing to Atherosclerosis: From Humans to Mice and Back Again....Pages 299-306 Genetic Manipulation of Lipoprotein Receptors: Implications for Lipid Metabolism and Atherosclerosis....Pages 307-312 Genetic Models of Vascular Disease....Pages 313-315 Generation and Characterization of Apolipoprotein Cl-Deficient Mice....Pages 317-322 Studies of Apolipoprotein B And Lipoprotein(a) in Transgenic Mice....Pages 323-326 Isolation of Novel Genes Regulated by Dietary Cholesterol by a Pcr-Based Subtraction Library....Pages 327-332 Cholesterol and Mortality: What Can Meta-Analysis Tell Us?....Pages 333-340 Screening for High Blood Cholesterol: A Risky Business....Pages 341-346 Cholesterol Lowering, Low Cholesterol, and Mortality....Pages 347-351 Bavarian Cholesterol Screening Project (Bcsp)....Pages 353-357 Back Matter....Pages 359-366 Edited By Linda L. Gallo. Proceedings Of The Fourteenth Washington International Spring Symposium At The George Washington University, Held June 6-10, 1994, In Washington, D.c.--t.p. Verso. Includes Bibliographical References And Index. Proceedings of the Fourteenth Washington International Spring Symposium at the George Washington University held in Washington, D.C., June 6-10, 1994.