Cardiovascular Biomarkers: Pathophysiology and Disease Management (Contemporary Cardiology)

In the four pages committed to a discussion of myocardial infarction in the first edition of Harrison’s Principles of Internal Medicine, published in 1950, there was no mention of use of the laboratory for management of patients. Thirty years later, when the first edition of Braunwald’s Heart Disease, A Textbook of Cardiovascular Medicine was published, 2 out of the 1943 pages in the text contained a discussion of the laboratory examinations in acute myocardial infarction. Our knowledge base of the multitude of ways that physicians can and should use the clinical chemistry laboratory has expanded dramatically since these classic texts were published. The nomenclature has changed: terms such as “cardiac enzymes” have given way to “cardiac biomarkers. ” The number of assays has multiplied, and the operating characteristics of available assays are impr- ing at a gratifying but dizzying rate. We now use biomarkers to diagnose cardiovascular diseases and also to frame our treatment strategies. Thus, there is a clear need for a scholarly compilation of the state of the art of cardiac biomarkers. Dr. David Morrow has expertly edited an authoritative book that answers this need. The 34 chapters in Cardiovascular Biomarkers: Pathophysiology and Disease Mana- ment were written by a group of individuals who are internationally recognized thought leaders and experts in clinical and laboratory medicine. The Book Is Divided Into Seven Sections, Each Of Which Covers A Major Class Of Biomarkers (e.g. Biomarkers Of Necrosis, Biomarkers Of Inflammation, And Biomarkers Of Hemodynamic Stress). Each Section Begins With An Overview Of The Biology And Development Of Each Major Class, Followed By A Concise Review Of Analytic Issues Important To The Clinician, And Then By A Series Of Chapters Written By Internationally Recognized Experts Who Discuss Clinical Applications Of The Biomarkers. These Later Chapters Focus On The Incorporation Of Biomarkers Into The Contemporary Management Of Patients With Cardiovascular Disease, Emphasizing Clinical Studies, Evidence-based Diagnostic Algorithms, And Critical Pathways For Triage And Therapy. Biomarkers Of Myocardial Necrosis: Past, Present, And Future / Robert H. Christenson And Hassan M.e. Azzazy -- Analytical Issues For The Clinical Use Of Cardiac Troponin / Alan H.b. Wu -- Defining Myocardial Infarction / Allan S. Jaffe And Luciano Babuin -- Biomarkers In The Emergency Department: Rapid Diagnosis And Triage / Jin H. Han And W. Brian Gibler -- Cardiac Troponin For Risk Assessment And Management Of Non-st-elevation Acute Coronary Syndrome / Bertil Lindahl -- Biomarkers Of Necrosis For Risk Assessment And Management Of St-elevation Myocardial Infarction / Evangelos Giannitsis And Hugo A. Katus -- Cardiac Troponin After Revascularization Procedures / Warren J. Cantor And L. Kristin Newby -- Biomarkers Of Necrosis In Heart Failure: Past, Present, And Future Directions / Emil Missov, James Rider, And Leslie Miller -- Is There A Role For Cardiac Troponin And Other Biomarkers In Patients With Pulmonary Embolism? / Samuel Z. Goldhaber -- Cardiac Troponin In Conditions Other Than Acute Coronary Syndromes / Fred S. Apple And David A. Morrow -- Degradation Of Cardiac Troponins: Implications For Clinical Practice / Allan S. Jaffe And Jennifer E. Van Eyk. Developing A Marker Of Ischemia: Clinical And Research Challenges / Robert L. Jesse -- Emerging Biomarkers Of Myocardial Ischemia / Jesse E. Adams -- Inflammation In Cardiovascular Disease: The Biological Basis Of Inflammatory Biomarkers / Peter Libby -- Analytical Issues For The Clinical Use Of C-reactive Protein / Nader Rifai -- C-reactive Protein As A Tool For Risk Assessment In Primary Prevention / Shari S. Bassuk And Paul M. Ridker -- High-sensitivity C-reactive Protein For Risk Assessment In Acute Coronary Syndromes / Luigi M. Biasucci And Antonio Abbate -- Beyond C-reactive Protein: Novel Markers Of Vascular Inflammation / Christopher Heeschen -- Biomarkers Of Inflammation: Implications In Patients With Heart Failure / Biykem Bozkurt -- Biomarkers Of Infection And Risk Of Coronary Heart Disease / Joseph B. Muhlestein -- Biology Of The Natriuretic Peptides / Charlotte Kragelund And Torbjørn Omland -- Analytical Issues For The Clinical Use Of B-type Natriuretic Peptide And N-terminal Pro B-type Natriuretic Peptide / Johannes Mair. Clinical Use Of Natriuretic Peptides For The Diagnosis And Management Of Heart Failure / Alan Maisel -- Natriuretic Peptides In Acute And Chronic Coronary Artery Disease / Shuaib M. Abdullah And James A. De Lemos -- Novel Markers Of Hemodynamic Stress / Ellen O. Weinberg And Richard T. Lee -- Clinical And Research Applications Of Markers Of Thrombosis / Manesh R. Patel And Richard C. Becker -- Measures Of Platelet Activation And Aggregation / Jean-philippe Collet And Gilles Montalescot -- Monocyte-platelet Aggregates In Patients With Ischemic Heart Disease / Matthew D. Linden And Mark I. Furman -- Measurement Of Atherogenic Lipoproteins In Cardiovascular Risk Assessment / Richard L. Dunbar And Daniel J. Rader -- Lipoprotein-associated Phospholipase A2 And Other Lipid-related Biomarkers In Cardiovascular Disease / Natalie Khuseyinova And Wolfgang Koenig -- A Multimarker Approach To Evaluation Of Patients With Acute Coronary Syndrome / David A. Morrow -- Cardiac Biomarkers By Point-of-care Testing / Paul O. Collinson -- Proteomics And Cardiovascular Biomarker Discovery / Emerson Liu And Robert E. Gerszten -- Genetic Markers In Cardiovascular Disease / Marc S. Sabatine. Edited By David A. Morrow ; Foreword By Elliot Antman. Includes Bibliographical References And Index. System Requirements For Accompanying Cd-rom: Pc Or Macintosh. Mode Of Access: World Wide Web. Biomarkers of myocardial necrosis: past, present, and future / Robert H. Christenson and Hassan M.E. Azzazy Analytical issues for the clinical use of cardiac troponin / Alan H.B. Wu Defining myocardial infarction / Allan S. Jaffe and Luciano Babuin Biomarkers in the emergency department: rapid diagnosis and triage / Jin H. Han and W. Brian Gibler Cardiac troponin for risk assessment and management of non-ST elevation acute coronary syndrome / Bertil Lindahl Biomarkers of necrosis for risk assessment and management of ST-segment elevation myocardial infarction / Evangelos Giannitsis and Hugo A. Katus Cardiac troponin after revascularization procedures / Warren J. Cantor and L. Kristin Newby Biomarkers of necrosis in heart failure: past, present, and future directions / Emil Missov, James Rider, and Leslie Miller Is there a role for cardiac troponin and other biomarkers in patients with pulmonary embolism? / Samuel Z. Goldhaber Cardiac troponin in conditions other than acute coronary syndromes / Fred S. Apple and David A. Morrow Degradation of cardiac troponins: implications for clinical practice / Allan S. Jaffe and Jennifer E. Van Eyk Developing a marker of ischemia: clinical and research challenges / Robert L. Jesse Emerging biomarkers of myocardial ischemia / Jesse E. Adams Inflammation in cardiovascular disease: the biological basis of inflammatory biomarkers / Peter Libby Analytical issues for the clinical use of c-reactive protein / Nader Rifai C-reactive protein as a tool for risk assessment in primary prevention / Shari S. Bassuk and Paul M. Ridker High-sensitivity c-reactive protein for risk assessment in acute coronary syndromes / Luigi M. Biasucci and Antonio Abbate Beyond c-reactive protein: novel markers of vascular inflammation / Christopher Heeschen Biomarkers of inflammation: implications in patients with heart failure / Biykem Bozkurt Biomarkers of infection and risk of coronary heart disease / Joseph B. Muhlestein Biology of the natriuretic peptides / Charlotte Kragelund and Torbjørn Omland Analytical issues for the clinical use of b-type natriuretic peptide and n-terminal pro b-type natriuretic peptide / Johannes Mair Clinical use of natriuretic peptides for the diagnosis and management of heart failure / Alan Maisel Natriuretic peptides in acute and chronic coronary artery disease / Shuaib M. Abdullah and James A. de Lemos Novel markers of hemodynamic stress / Ellen O. Weinberg and Richard T. Lee Clinical and research applications of markers of thrombosis / Manesh R. Patel and Richard C. Becker Measures of platelet activation and aggregation / Jean-Philippe Collet and Gilles Montalescot Monocyte-platelet aggregates in patients with ischemic heart disease / Matthew D. Linden and Mark I. Furman Measurement of atherogenic lipoproteins in cardiovascular risk assessment / Richard L. Dunbar and Daniel J. Rader Lipoprotein-associated phospholipase A2 and other lipid-related biomarkers in cardiovascular disease / Natalie Khuseyinova and Wolfgang Koenig A multimarker approach to the evaluation of patients with acute coronary syndromes / David A. Morrow Cardiac biomarkers by point-of-care testing / Paul O. Collinson Proteomics and cardiovascular biomarker discovery / Emerson Liu and Robert E. Gerszten Genetic markers in cardiovascular disease / Marc S. Sabatine. So rapidly has the number of cardiac assays available grown, and then improved, that current biomarkers not only diagnose cardiovascular disease, but also frame treatment strategies. In Cardiovascular Biomarkers: Pathophysiology and Disease Management, a distinguished panel of internationally recognized opinion makers and experts in clinical and laboratory medicine synthesize the latest developments in the use of cardiac biomarkers by the practicing physician. The authors focus on integrating biomarkers into the contemporary clinical management of patients with cardiovascular disease, emphasizing clinical studies, evidence-based diagnostic algorithms, and critical pathways for triage and therapy, whenever available. They also illuminate the connections between specific biomarkers and the basic pathophysiology of cardiovascular disease, explain the analytical properties of the assays relevant to clinical practice, and highlight emerging biomarkers and novel directions for biomarker development. Numerous figures, illustrations, and tables make key evidence and practical guidelines easily accessible. State-of-the-art and highly practical, Cardiovascular Biomarkers: Pathophysiology and Disease Management makes clear to today's busy cardiologists, emergency room physicians, and internists how the various assays perform, which ones they should order when evaluating their patients, and how the results of a biomarker assay can guide their therapeutic approaches