Cardiomyopathies and Heart Failure: Biomolecular, Infectious and Immune Mechanisms (Developments in Cardiovascular Medicine, 248)

This volume comprises the most up-to-date account of existing knowledge on the subject of cardiomyopathy and heart failure. Its multidisciplinary approach covers cardiovascular medicine; biochemistry; immunology; molecular biology; virology; epidemiology; and clinical medicine. **Cardiomyopathies and Heart Failure:**-Covers all major investigational and clinical aspects of the topic; -Provides syntheses as well as reviews; -Offers a unique multidisciplinary and international perspective; -Includes an extensive list of references to relevant work; -Targeted towards practicing physicians and basic researchers. Front Matter....Pages i-xxi Front Matter....Pages 1-1 Cardiomyopathies and Heart Failure....Pages 1-15 Front Matter....Pages 17-17 Chemokines and Cardiovascular Diseases....Pages 17-25 Negative Regulator of Cytokine Signaling (SOCS) Genes in Inflammation....Pages 27-38 The Interleukin-6 Family of Cytokines and their Receptors in Patients with Congestive Heart Failure....Pages 39-46 Animal Model of Cardiomyopathy Due to Overexpression of TNF-α....Pages 47-58 Front Matter....Pages 59-59 Myosin Autoreactive T Cells And Autoimmune Myocarditis. Lessons from the Disease Caused by Cardiac Myosin Peptide CM2....Pages 59-65 Autoimmunity in Cardiomyopathies....Pages 67-81 Anti-G-Protein-Coupled Cardiac Receptor Autoantibodies in Dilated Cardiomyopathy....Pages 83-96 Clinical Significance of Circulating Cardiac Autoantibodies in Dilated Cardiomyopathy and Myocarditis....Pages 97-109 Front Matter....Pages 111-111 Development of Mast Cells: Process and Regulatory Mechanisms....Pages 111-120 Mast Cells in Experimental Myocardial Infarction....Pages 121-132 Possible Involvement of Mast Cells in the Development of Fibrosis....Pages 133-144 Human Mast Cell Chymase and 31 Amino Acid Endothelin-1....Pages 145-158 Tryptase From Human Mast Cells....Pages 159-172 Effects of the Tryptase Receptor Activating Peptide and Antibodies Against the Tryptase Receptor Par-2 on Neonatal Rat Cardiomyocytes in Culture....Pages 173-184 Front Matter....Pages 185-185 Role of Human Heart Mast Cells in Immunologic and Inflammatory Mechanisms Underlying Cardiovascular Disorders....Pages 185-198 Mast Cells in Atherosclerotic Human Coronary Arteries: Implications for Coronary Fatty Streak Formation and Plaque Erosion or Rupture....Pages 199-212 The Key Role of Mast Cells in the Evolution to Congestive Heart Failure....Pages 213-228 Front Matter....Pages 229-229 Links Between Viral Infections and Heart Disease....Pages 229-243 Molecular Detection and Characterization of Human Enteroviruses....Pages 245-257 Front Matter....Pages 229-229 Detection and Biological Implications of Genetic Memory in Viral Quasispecies....Pages 259-276 The Group B Coxsackieviruses as Vaccines and Vectors....Pages 277-290 Detection of Important Diagnostic Markers of HCV Infection....Pages 291-299 Front Matter....Pages 301-301 Large Animal Model of Viral Myocarditis....Pages 301-324 Hepatitis Cvirus and Cardiomyopathy....Pages 325-339 Diagnosis and Treatment of Myocarditis: The Role of Adenovirus Infection in Cardiomyopathy and Heart Failure....Pages 341-355 The Natural History of Viral Myocarditis: Pathogenetic Role of Adrenergic System Dysfunction in the Development of Idiopathic Dilated Cardiomyopathy....Pages 357-372 Clinical Diagnosis of Myocarditis....Pages 373-388 Recent Advances in Giant Cell Myocarditis....Pages 389-400 Registry of Myocarditis and Heart Failure....Pages 401-414 Front Matter....Pages 415-415 Molecular Etiology of Idiopathic Cardiomyopathy....Pages 415-428 Gene-Based Therapy of Long QT Syndrome....Pages 429-438 Front Matter....Pages 439-439 How Does Adenosine Mediate Cardioprotection?....Pages 439-455 Protection of Cell Injury by Thioredoxin....Pages 457-468 Hematopoietic Stem Cells and Angiogenesis....Pages 469-480 Transplanting Cells for the Treatment of Cardiomyopathy....Pages 481-489 Toward an Ideal Large Animal Model of Dilated Cardiomyopathy to Study Left Ventricular Volume Reduction Surgery....Pages 491-501 Heart Transplantation: 35 Years of Progress....Pages 503-514 Genes of the Major Histocompability Complex Class II Influence the Phenotype of Cardiomyopathies Associated With Hepatitis C Virus Infection....Pages 515-521 Back Matter....Pages 523-531 This volume comprises the most up-to-date account of existing knowledge on the subject of cardiomyopathy and heart failure. Its multidisciplinary approach covers cardiovascular medicine; biochemistry; immunology; molecular biology; virology; epidemiology; and clinical medicine. Cardiomyopathies and Heart Failure: -Covers all major investigational and clinical aspects of the topic; -Provides syntheses as well as reviews; -Offers a unique multidisciplinary and international perspective; -Includes an extensive list of references to relevant work; -Targeted towards practicing physicians and basic researchers.