Cardiac Remodeling: Molecular Mechanisms (Advances in Biochemistry in Health and Disease Book 5)

The main objective of __Cardiac Remodeling: Molecular Mechanisms__ is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside. Front Matter....Pages i-xi Front Matter....Pages 1-1 β-Adrenergic Receptor Signaling in Heart Failure....Pages 3-30 Remodeling of Potassium Channels in Cardiac Hypertrophy....Pages 31-45 Role of Gender in Ca 2+ Cycling and Cardiac Remodeling Due to Heart Failure....Pages 47-64 The Failing Heart: Is It an Inefficient Engine or an Engine Out of Fuel?....Pages 65-84 Regulation of Cardiac Hypertrophic Remodeling by the USP15/SLIM1 Pathway....Pages 85-96 Role of Galectin-3 Pathways in the Pathogenesis of Cardiac Remodeling and Heart Failure....Pages 97-111 A Mitochondriocentric Pathway to Cardiomyocyte Necrosis: An Upstream Molecular Mechanism in Myocardial Fibrosis....Pages 113-125 The ACE2/Ang (1–7) Pathway in Cardiac Remodeling Due to Pressure Overload....Pages 127-139 Local Actions of Natriuretic Peptides and Nitric Oxide in Cardiac Remodeling: Implications for Therapy....Pages 141-158 Modulating G Protein-Coupled Receptors to Effect Reverse Cardiac Remodeling....Pages 159-177 Role of Inflammation and Matrix Proteinases in Cardiac Remodeling Following Stress and Injury....Pages 179-200 Role of Chymase in Matrix and Myocardial Remodeling Due to Mitral Regurgitation: Implications for Therapy....Pages 201-214 Cardiac Remodeling Due to Aortic Regurgitation and Mitral Regurgitation....Pages 215-226 Reducing Oxidative Stress and Manipulating Molecular Signaling Events Using Resveratrol as a Therapy for Pathological Cardiac Hypertrophy....Pages 227-254 Angiogenesis, Arteriogenesis, and Mitochondrial Dysfunction....Pages 255-272 Front Matter....Pages 273-273 Subcellular Remodeling and Cardiac Dysfunction Due to Ischemia–Reperfusion Injury....Pages 275-291 Role of MicroRNAs in Cardiac Hypertrophy and Postinfarction Remodeling....Pages 293-311 Negative Regulators of Inflammation as Endogenous Protective Mechanisms in Postinfarction Remodeling....Pages 313-330 TLR-Dependent Pathways and Akt/mTOR/P70S6K Pathways in Cardiac Remodeling After Myocardial Infarction....Pages 331-345 The STAT3 Pathway and Downstream Mechanisms in Cardiac Remodeling: Friend or Foe....Pages 347-364 Front Matter....Pages 273-273 The Role of Growth Differentiation Factor 5 in Cardiac Repair Post-Myocardial Infarction....Pages 365-382 Extracellular Matrix Biomarkers of Adverse Remodeling After Myocardial Infarction....Pages 383-412 Oxidative Stress in Cardiac Repair and Remodeling: Molecular Pathways and Therapeutic Strategies....Pages 413-425 Role of SPARC in Cardiac Extracellular Matrix Remodeling After Myocardial Infarction....Pages 427-444 Tissue Inhibitor of Matrix Metalloproteinases in the Pathogenesis of Heart Failure Syndromes....Pages 445-465 Intracellular Matrix Remodeling and Cardiac Function in Ischemia–Reperfusion Injury....Pages 467-485 Aging and Markers of Adverse Remodeling After Myocardial Infarction....Pages 487-512 Optimizing Stem Cell Therapy for Cardiac Repair Following a Myocardial Infarction....Pages 513-524 Regulation of Fibrosis After Myocardial Infarction: Implications for Ventricular Remodeling....Pages 525-545 The ACE2/Ang-(1–7) Pathway in Cardiac Fibroblasts as a Potential Target for Cardiac Remodeling....Pages 547-557 Back Matter....Pages 559-569