Cardiac Glycosides: Part I: Experimental Pharmacology (Handbook of Experimental Pharmacology (56 / 1))

Following the monographs by STRAUB (1924) and LENDLE (1935), this is the third contribution to the "Pharmacology of Cardiac Glycosides" within the Handbook of Experimental Pharmacology, which was founded by ARTHUR HEFFTER and con­ tinued by WOLFGANG HEUBNER. Because of the need created by the length of time that had elapsed since LENDLE'S work, the editorial board requested the rapid ap­ pearance of this 56th volume, which represents current knowledge of the pharma­ cology and clinical pharmacology of cardiac glycosides. In order to avoid any delay, numerous authors were invited to contribute because shorter contributions take less time to prepare and are consequently more up-to-date. The disadvantage is that some overlap between certain chapters could not be avoided, despite the editor's efforts. Overlapping can, however, actually be useful, in that differing opinions may be provided and topical issues discussed from varying viewpoints. This re­ minds the reader that scientific horizons in medicine should often be widened or revised. I would like to thank DR. ALANNA Fox and DR. K. ANANTHARAMAN for their help and advice in the revision of certain chapters. I am also grateful to Springer­ Verlag, and particularly to MR. WINSTANLEY and MR. EMERSON, for their contribu­ tion to the completion of this volume through translation and corrections. In con­ clusion I would like to thank MRS. WALKER, MR. BISCHOFF, MRS. SEEKER, and MR. BERGSTEDT of Springer-Verlag for their helpful support. Front Matter....Pages I-XXIV Introduction and Remarks on the History of Cardiac Glycosides....Pages 1-12 Chemistry and Structure-Activity Relationships of Cardioactive Steroids....Pages 13-24 Front Matter....Pages 25-25 Chemical and Chromatographic Methods....Pages 27-42 Use of Radioactively Labeled Glycosides....Pages 43-55 Radioimmunologic Methods....Pages 57-81 ATPase for the Determination of Cardiac Glycosides....Pages 83-94 Rubidium Uptake in Erythrocytes....Pages 95-113 Front Matter....Pages 115-115 Evaluation of Cardiac Glycosides in the Intact Animal....Pages 117-152 The Use of the Isolated Papillary Muscle for the Evaluation of Positive Inotropic Effects of Cardioactive Steroids....Pages 153-159 Evaluation of Cardiac Glycosides in Isolated Heart Preparations Other than Papillary Muscle....Pages 161-184 Front Matter....Pages 185-185 The Positive Inotropic Action of Cardiac Glycosides on Cardiac Ventricular Muscle....Pages 187-219 Influence of Cardiac Glycosides on Electrophysiologic Processes....Pages 221-254 Influence of Cardiac Glycosides on Myocardial Energy Metabolism....Pages 255-285 Effects of Cardiac Glycosides on Na + , K + -ATPase....Pages 287-336 Influence of Cardiac Glycosides on their Receptor....Pages 337-380 Stimulation and Inhibition of the Na + , K + -Pump by Cardiac Glycosides....Pages 381-393 Influence of Cardiac Glycosides on Cell Membrane....Pages 395-406 Influence of Cardiac Glycosides on Electrolyte Exchange and Content in Cardiac Muscle Cells....Pages 407-436 Effects of Cardiac Glycosides on Myofibrils....Pages 437-457 Substances Possessing Inotropic Properties Similar to Cardiac Glycosides....Pages 459-486 Front Matter....Pages 487-487 Effects of Cardiac Glycosides on Central Nervous System....Pages 489-496 Effects of Cardiac Glycosides on Vascular System....Pages 497-515 Effects of Cardiac Glycosides on Skeletal Muscle....Pages 517-532 Effects of Cardiac Glycosides on Autonomic Nervous System and Endocrine Glands....Pages 533-550 Effects of Cardiac Glycosides on Kidneys....Pages 551-577 Back Matter....Pages 579-684