Cardiac glycoside receptors and positive inotropy : evidence for more than one receptor? : symposium, Munich, October 26-29, 1983

The symposium was held under the auspices of the Arbeitsgruppe positiv inotrope Phannaka der Deutschen Gesellschaft fUr Herz-und Kreislaufforschung and the Working group Drug Therapy in Cardiology of the European Society of Cardiology. Front Matter....Pages 1-6 Cardiac glycoside receptors and positive inotropy Evidence for more than one receptor?....Pages 7-8 Theory of ligand — receptor interactions — Evidence for more than one site....Pages 9-15 Cardiac Glycosides and sodium/potassium-ATPase....Pages 16-20 Two receptors for cardiac glycosides in the heart....Pages 21-26 Subclassification of cardiac glycoside receptors....Pages 27-34 Cardiac glycoside binding sites in cultured heart muscle cells....Pages 35-43 Binding sites for ouabain in human and rat erythrocytes and in rat heart cells....Pages 44-49 Two binding sites for ouabain in cardiac cell membranes....Pages 50-55 Contractility of isolated bovine ventricular myocytes is enhanced by intracellular injection of cardioactive glycosides. Evidence for an intracellular mode of action....Pages 56-71 The electrogenic Na-K pump current and actions of the cardiac glycosides....Pages 72-78 Effects of non-toxic doses of ouabain on sodium, potassium, calcium distribution in guinea pig papillary muscle. Electronprobe microanalysis....Pages 79-86 Cardiac glycosides and intracellular Na + , K + , Ca 2+ ....Pages 87-92 Cardiac glycosides with different effects in the heart....Pages 93-101 Biphasic positive inotropic actions of ouabain on rat, guinea-pig and cat heart: a mathematical description....Pages 102-109 Digitalis receptors affinity labelling and relation with positive inotropic and cardiotoxic effects....Pages 110-118 Two ouabain binding sites in guinea pig heart Na + -K + - ATPase. Differentiation by sodium and erythrosin B....Pages 119-127 Effects of calcium on the heterogeneity of the Na + , K + -ATPase forms in rat heart....Pages 128-133 Positive inotropic effects of digitoxin- and digoxin-glucuronide in human isolated ventricular heart muscle preparations....Pages 134-139 Studies of the inotropic mechanisms of cardiac glycosides in cultured heart cells....Pages 140-146 Therapeutic range of cardiac glycosides....Pages 147-153 Increased therapeutic range, merely a pharmacokinetic problem?....Pages 154-160 Back Matter....Pages 161-162