Cardiac Electrophysiology: From Cell to Bedside (Expert Consult Title: Online + Print)

**__Cardiac Electrophysiology: From Cell to Bedside__** puts the **latest knowledge in this subspecialty** at your fingertips, giving you a **well-rounded, expert grasp of every cardiac electrophysiology issue** that affects your patient management. **Drs. Zipes, Jalife**, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approachto guide you through all ofthe most recent cardiac drugs, techniques, and technologies. * **Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management** from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world. * **Visually grasp and easily absorb complex concepts** through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more! * **Integrate the latest scientific understanding of arrhythmias** with the **newest clinical applications**, to select the right treatment and management options for each patient. * **Stay current on the latest advancements and developments** with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques. * **Get expert advice from Dr. Douglas P. Zipes** - a leading authority in electrophysiology and editor of __Braunwald's Heart Disease__ and the __Heart Rhythm Journal__ - and **Dr. Jose Jalife** - a world-renowned leader and researcher in basic and translational cardiac electrophysiology. * **Access the full text online at Expert Consult**, including supplemental text, figures, tables, and video clips. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued Content: Front Matter , Page i Copyright , Page ii Contributors , Pages iii-xvi Preface , Page xvii Video Contents , Page xxvi 1 - Voltage-Gated Sodium Channels and Electrical Excitability of the Heart , Pages 1-11 2 - Calcium Channels in the Heart , Pages 13-22 3 - Voltage-Regulated Potassium Channels , Pages 23-32 4 - Structural and Molecular Bases of Cardiac Inward Rectifier Potassium Channel Function , Pages 33-41 5 - Mammalian Calcium Pumps in Health and Disease , Pages 43-53 6 - Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function , Pages 55-69 7 - Structural and Molecular Bases of Mitochondrial Ion Channel Function , Pages 71-84 8 - Molecular Organization, Gating, and Function of Gap Junction Channels , Pages 85-94 9 - Biophysics of Normal and Abnormal Cardiac Sodium Channel Function , Pages 95-101 10 - Regulation of Cardiac Calcium Channels , Pages 103-113 11 - KCNQ1/KCNE1 Macromolecular Signaling Complex: Channel Microdomains and Human Disease , Pages 115-120 12 - Structural Determinants and Biophysical Properties of hERG1 Channel Gating , Pages 121-128 13 - Molecular Regulation of Cardiac Inward Rectifier Potassium Channels by Pharmacologic Agents , Pages 129-137 14 - Cardiac Stretch–Activated Channels and Mechano-Electric Coupling , Pages 139-149 15 - Biophysical Properties of Gap Junctions , Pages 151-160 16 - Excitation-Contraction Coupling , Pages 161-169 17 - Ion Channel Trafficking in the Heart , Pages 171-178 18 - Macromolecular Complexes and Regulation of the Sodium Channel Na v 1.5 , Pages 179-188 19 - Calmodulin and CaMKII as Ca 2+ Switches for Cardiac Ion Channels , Pages 189-195 20 - Macromolecular Complexes and Cardiac Potassium Channels , Pages 197-204 21 - Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias , Pages 205-214 22 - The Intercalated Disc: A Molecular Network That Integrates Electrical Coupling, Intercellular Adhesion, and Cell Excitability , Pages 215-227 23 - Scaffolding Proteins and Ion Channel Diseases , Pages 229-234 24 - Epigenetics in Cardiac Rhythm Diseases , Pages 235-241 25 - Cardiac Impulse Is Initiated by a Coupled System of Membrane Ion Channels and Ca 2+ Cycling Proteins , Pages 243-252 26 - Biological Pacing , Pages 253-263 27 - Intercellular Communication and Impulse Propagation , Pages 265-274 28 - Mechanisms of Atrioventricular Nodal Excitability and Propagation , Pages 275-285 29 - Cell Biology of the Specialized Cardiac Conduction System , Pages 287-296 30 - Cardiac Fibroblasts and Arrhythmogenesis , Pages 297-308 31 - Ionic Mechanisms of Atrial Action Potentials , Pages 309-318 32 - Models of the Ventricular Action Potential in Health and Disease , Pages 319-330 33 - Calcium Signaling in Cardiomyocyte Models With Realistic Geometries , Pages 331-340 34 - Theory of Rotors and Arrhythmias , Pages 341-350 35 - Supraventricular Arrhythmias in a Realistic 3D Model of the Human Atria , Pages 351-359 36 - Cardiac Electromechanical Models , Pages 361-369 37 - Ca V 1.2 and β-Adrenergic Regulation of Cardiac Function , Pages 371-381 38 - Cholinergic and Constitutive Regulation of Atrial Potassium Channel , Pages 383-391 39 - Pulmonary Vein Ganglia and the Neural Regulation of the Heart Rate , Pages 393-398 40 - Neural Activity and Atrial Tachyarrhythmias , Pages 399-407 41 - Sympathetic Innervation, Denervation, and Cardiac Arrhythmias , Pages 409-417 42 - Dominant Frequency and the Mechanisms of Initiation and Maintenance of Atrial Fibrillation , Pages 419-432 43 - Rotors in Human Atrial Fibrillation , Pages 433-442 44 - Atrial Ischemia and Fibrillation , Pages 443-448 45 - The Molecular Pathophysiology of Atrial Fibrillation , Pages 449-458 46 - Myofibroblasts, Cytokines, and Persistent Atrial Fibrillation , Pages 459-467 47 - Role of the Autonomic Nervous System in Atrial Fibrillation , Pages 469-474 48 - Mechanisms of Ventricular Tachycardia and Fibrillation , Pages 475-482 49 - Genetics of Atrial Fibrillation , Pages 483-490 50 - Mechanisms in Heritable Sodium Channel Diseases , Pages 491-500 51 - Inheritable Potassium Channel Disease , Pages 501-509 52 - Genetics and Cellular Mechanisms of the J Wave Syndromes , Pages 511-519 53 - Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation , Pages 521-528 54 - Pharmacologic Bases of Antiarrhythmic Therapy , Pages 529-540 55 - Pharmacogenomics of Cardiac Arrhythmias , Pages 541-547 56 - Optogenetic Control of Heart Muscle , Pages 549-557 57 - Cell Therapy and Regenerative Electrophysiology , Pages 559-566 58 - Assessment of the Patient With a Cardiac Arrhythmia , Pages 567-573 59 - Differential Diagnosis of Narrow and Wide Complex Tachycardias , Pages 575-580 60 - Mapping and Imaging , Pages 581-593 61 - CT and MRI for Electrophysiology , Pages 595-603 62 - Intracardiac Echocardiography for Electrophysiology , Pages 605-612 63 - Exercise-Induced Arrhythmias , Pages 613-619 64 - Cardiac Monitoring: Short- and Long-Term Recording , Pages 621-627 65 - Electrocardiographic Imaging in Patients With Acute Coronary Syndrome , Pages 629-635 66 - Head-up Tilt Table Testing , Pages 637-648 67 - Autonomic Testing and Cardiac Risk , Pages 649-656 68 - Monophasic Action Potential Recording , Pages 657-663 69 - T Wave Alternans , Pages 665-676 70 - Noninvasive Electrocardiographic Imaging of Human Ventricular Arrhythmias and Electrophysiological Substrate , Pages 677-684 71 - Genetic Testing , Pages 685-690 72 - Sinus Node Abnormalities , Pages 691-697 73 - Atrial Tachycardia , Pages 699-722 74 - Typical and Atypical Atrial Flutter: Mapping and Ablation , Pages 723-737 75 - Atrial Fibrillation: Paroxysmal, Persistent, and Permanent , Pages 739-754 76 - Preexcitation, Atrioventricular Reentry, and Variants , Pages 755-765 77 - Electrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Reentrant Circuits , Pages 767-787 78 - Atrial Tachyarrhythmias in Adults With Congenital Heart Disease , Pages 789-799 79 - Junctional Tachycardia , Pages 801-807 80 - Premature Ventricular Complexes , Pages 809-813 81 - Outflow Tract Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management , Pages 815-825 82 - Fascicular Ventricular Arrhythmias , Pages 827-833 83 - Bundle Branch Reentry Tachycardia , Pages 835-847 84 - Ischemic Heart Disease , Pages 849-857 85 - Ventricular Tachycardia in Patients With Dilated Cardiomyopathy , Pages 859-871 86 - Ventricular Arrhythmias in Hypertrophic Cardiomyopathy , Pages 873-883 87 - Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy , Pages 885-894 88 - VTs in Catecholaminergic Cardiomyopathy (Catecholaminergic Polymorphic Ventricular Tachycardia) , Pages 895-902 89 - Ventricular Arrhythmias in Heart Failure , Pages 903-912 90 - Ventricular Tachycardia in Noncompaction Cardiomyopathy , Pages 913-918 91 - Ventricular Arrhythmias in Takotsubo Cardiomyopathy , Pages 919-924 92 - Brugada Syndrome 1992–2012: Twenty Years of Scientific Progress , Pages 925-933 93 - Long and Short QT Syndromes , Pages 935-946 94 - Andersen-Tawil Syndrome , Pages 947-952 95 - Timothy Syndrome , Pages 953-957 96 - J Wave Syndromes , Pages 959-965 97 - Idiopathic Ventricular Fibrillation , Pages 967-973 98 - Sudden Infant Death Syndrome , Pages 975-979 99 - Sudden Cardiac Death in Adults , Pages 981-991 100 - Arrhythmias in Patients With Neurologic Disorders , Pages 993-999 101 - Drug-Induced Ventricular Tachycardia , Pages 1001-1008 102 - Ventricular Arrhythmias in Congenital Heart Disease , Pages 1009-1019 103 - Syncope , Pages 1021-1027 104 - Postural Orthostatic Tachycardia Syndrome , Pages 1029-1034 105 - Progressive Conduction System Disease , Pages 1035-1042 106 - Atrioventricular Block , Pages 1043-1049 107 - Sex Differences in Arrhythmias , Pages 1051-1059 108 - Sudden Cardiac Deaths in Athletes, Including Commotio Cordis , Pages 1061-1072 109 - Arrhythmias in Pediatric Population , Pages 1073-1086 110 - Sleep-Disordered Breathing and Arrhythmias , Pages 1087-1093 111 - Standard Antiarrhythmic Drugs , Pages 1095-1110 112 - New Antiarrhythmic Drugs and New Concepts for Old Drugs , Pages 1111-1119 113 - Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death , Pages 1121-1128 114 - Prevention of Stroke in Patients With Atrial Fibrillation , Pages 1129-1137 115 - Implantable Cardioverter Defibrillators: Technical Aspects , Pages 1139-1150 116 - Implantable Cardioverter Defibrillator: Clinical Aspects , Pages 1151-1165 117 - Implantable Pacemakers , Pages 1167-1177 118 - Cardiac Resynchronization Therapy , Pages 1179-1189 119 - Newer Applications of Pacemakers , Pages 1191-1197 120 - Catheter Ablation: Technical Aspects , Pages 1199-1207 121 - Catheter Ablation: Clinical Aspects , Pages 1209-1224 122 - Ablation for Atrial Fibrillation , Pages 1225-1238 123 - Ablation of Supraventricular Tachyarrhythmias , Pages 1239-1248 124 - Catheter Ablation for Ventricular Tachycardia in Patients With Structural Heart Disease , Pages 1249-1261 125 - Special Ablation Approaches: Epicardial, Other , Pages 1263-1276 126 - Ablation in Pediatrics , Pages 1277-1284 127 - Catheter Ablation in Congenital Heart Disease , Pages 1285-1294 128 - Surgery for Atrial Fibrillation and Other SVTs , Pages 1295-1305 129 - Surgery for Ventricular Arrhythmias , Pages 1307-1314.e1 130 - Vagal Stimulation for Heart Failure , Pages 1315-1320 131 - Spinal Cord Stimulation for Heart Failure and Arrhythmias , Pages 1321-1324 132 - Left Atrial Occluders/Isolation , Pages 1325-1332 Index , Pages 1333-1365

Cardiac Electrophysiology: From Cell to Bedside defines the entire state of current scientific and clinical knowledge in this subspecialty. In response to the many major recent developments in the field, Drs. Zipes and Jalife have completely updated this modern classic, making the 5th Edition the most significant revision yet. From our latest understanding of ion channels, molecular genetics, and cardiac electrical activity through newly recognized syndromes, unique needs of special patient populations, and new diagnostic and therapeutic options, you'll find all the state-of-the-art guidance you need to make informed, effective clinical decisions. What's more, a significantly restructured organization, a new full-color layout, and full-text online access make reference easier than ever.

• Integrates the latest scientific understanding of arrhythmias with the newest clinical applications, giving you an informed basis for choosing the right treatment and management options for each patient.
• Synthesizes the knowledge of preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world, giving you a well-rounded, expert grasp of every issue that affects your patient management.

• Contains 24 new chapters (listed below) as well as exhaustive updates throughout, to keep you current with new scientific knowledge, newly discovered arrhythmia syndromes, and new diagnostic and therapeutic techniques.

• Developmental Regulation of Cardiac Ion Channels
• Neural Mechanisms of Initiating and Maintaining Arrhythmias
• Single Nucleotide Polymorphisms and Acquired Cardiac Arrhythmias
• Inheritable Sodium Channel Diseases
• Inheritable Potassium Channel Diseases
• Inheritable Diseases of Intracellular Calcium Regulation
• Morphological Correlates of Atrial Arrhythmias
• Andersen-Tawil Syndrome
• Timothy Syndrome
• Progressive Cardiac Conduction Disease
• Sudden Infant Death Syndrome
• Arrhythmias in Patients with Neurologic Disorders
• Autonomic Testing
• Cardiac Resynchronization Therapy
• Energy Sources for Catheter Ablation
• Linear Lesions to Ablate Atrial Fibrillation
• Catheter Ablation of Ventricular Arrhythmias in Patients with Structural Heart Disease
• Catheter Ablation of Ventricular Arrhythmias in Patients without Structural Heart Disease
• Catheter Ablation in Patients with Congenital Heart Disease

• Features a completely new section on Arrhythmias in Special Populations that explores arrhythmias in athletes ... gender differences in arrhythmias ... arrhythmias in pediatric patients ... and sleep-disordered breathing and arrhythmias.
• Offers an attractive new full-color design featuring color photos, tables, flow charts, ECGs, and more, making clinically actionable information easy to find and absorb at a glance.
• Includes full-text online access via Expert Consult, making reference easier for busy practitioners.

Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued.

The book contains predominantly black-and-white illustrations, with some color illustrations.

Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife , and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world. Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more! Integrate the latest scientific understanding of arrhythmias with the newest clinical applications , to select the right treatment and management options for each patient. Stay current on the latest advancements and developments with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques. Get expert advice from Dr. Douglas P. Zipes - a leading authority in electrophysiology and editor of Braunwald's Heart Disease and the Heart Rhythm Journal - and Dr. Jose Jalife - a world-renowned leader and researcher in basic and translational cardiac electrophysiology. Access the full text online at Expert Consult , including supplemental text, figures, tables, and video clips. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, no