Cancer therapy new trends ; [proceedings of a conference held in July 1988 in Heidelberg, Germany, organized by the Committee Coordinating Cancer Research in the Großforschungseinrichtungen in the Federal Republic of Germany

In more than 20 contributions new trends in cancer therapy are reviewed and critically discussed by highly competent authors. Their contributions are based on an international symposium and cover all major fields of clinical oncology. Special emphasis is given to surgical oncology (including photodynamic laser therapy and radiosurgery), radiation oncology, hyperthermia, new antineoplastic agents, enzyme-pattern-targeted chemotherapy, drug resistance, biological response modifiers, bone marrow transplantation, antibody guided therapy, induction of cell differentiation in transformed cells, and the individualization of tumor therapy. The stimulating discussion at the end of each section covering these topics will particulary benefit the clinical oncologist and all researchers devoted to the improvement of cancer therapy. Front Matter....Pages I-XVI Front Matter....Pages 1-1 Advances in Surgical Oncology....Pages 3-7 Photodynamic Laser Therapy of Photosensitized Tumors....Pages 8-13 Radiosurgery with a Linear Accelerator: Method, Indications and Preliminary Results....Pages 14-17 Back Matter....Pages 18-19 Front Matter....Pages 21-21 New Trends in Radiation Therapy: Fast Neutrons and New Particles....Pages 23-31 Altered Fractionation in Radiotherapy....Pages 32-36 New Trends in Computer-Assisted Radiotherapy with Conventional Radiation....Pages 37-48 Intraoperative Radiation Therapy for Glioblastoma — Indications and Treatment Results....Pages 49-57 Back Matter....Pages 58-60 Front Matter....Pages 61-61 Hyperthermia in Tumor Treatment....Pages 63-70 Regional Hyperthermia and Systemic Chemotherapy....Pages 71-76 Back Matter....Pages 77-80 Front Matter....Pages 81-81 New Trends in Chemotherapy of Tumors....Pages 83-94 New Antineoplastic Agents....Pages 95-110 Enzyme-Pattern-Targeted Chemotherapy....Pages 111-119 Nuclear Components and Plasma Membrane as Targets of Chemotherapeutic Agents....Pages 120-127 Drug Resistant Cells as Targets for Chemotherapeutic Agents....Pages 128-134 Back Matter....Pages 135-136 Front Matter....Pages 137-137 Biological Response Modifiers: Mechanisms of Action....Pages 139-150 Biological Response Modifiers: Clinical Aspects....Pages 151-162 Predictive Assays for the Individualization of Tumor Therapy....Pages 163-169 Molecular Genetic Changes as Indicators of Therapeutic Effectiveness....Pages 170-177 Back Matter....Pages 178-178 Front Matter....Pages 179-179 Allogeneic Marrow Transplantation in Acute Leukemia and Chronic Myelogenous Leukemia — Johns Hopkins Experience....Pages 181-185 Autologous Bone Marrow Transplantation....Pages 186-191 Back Matter....Pages 192-193 Front Matter....Pages 195-195 Predictive Pharmacology of Monoclonal Antibodies....Pages 197-199 A New Approach in the Treatment of Advanced Ovarian Cancer and Brain Glioma Using Radiolabelled Monoclonal Antibodies....Pages 200-208 Ricin A Chain — Monoclonal Antibody 791T/36 Immunotoxin for Treatment of Colorectal and Ovarian Cancer....Pages 209-218 Experimental Approaches to Tumor Therapy with Monoclonal Antibodies....Pages 219-225 Back Matter....Pages 226-228 Front Matter....Pages 229-229 Induced Differentiation of Transformed Cells by Polar Compounds: From Molecular Studies to Clinical Trials....Pages 231-239 Hematopoietic Cytokines in Cancer Therapy: Concepts and First Clinical Observations....Pages 240-249 Back Matter....Pages 250-251 Back Matter....Pages 253-256