Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs (Paperback) – Highly Rated Pharmacology Book

__Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs__Whether you are a trainee, a clinical scientist, or a clinician in practice, the book is an ideal reference. It presents challenging information in an instructional way; it illustrates key concepts for ease of retention; and, it poses tough questions so readers can problem solve potential scenarios and test their pharmacologic acumen. Written by leading experts in oncopharmacology, this first-of-its kind manual is a "must have" for anyone involved in the basic, translational, or clinical aspects of oncology and hematology including clinicians, pharmacists, nurses, and trainees. * Includes visual depictions of chemical structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents * Describes how chemotherapy, targeted therapy, immunotherapy, hormonal therapy, work and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other modalities * Over 135 highly stylized images and numerous comprehensive tables * Covers challenges related to drug development, drug approval and regulatory issues in relation to anticancer treatments * All chapters conclude with clinical pearls and detailed clinical Q&As with descriptive rationales * Purchase includes access to the ebook for use on most mobile devices or computers

Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies. Beautifully illustrated throughout, each chapter contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book, and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Flow diagrams, clinical tables, and bulleted text further explain important information pertaining to each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring. Organized in an easyto- digest format and replete with detailed images, clinical pearls, and end of chapter Q&As, this evidence-based reference presents all major classes, agents, targets, and approaches to cancer pharmacotherapy.

Whether you are a trainee, a clinical scientist, or a clinician in practice, the book is an ideal reference. It presents challenging information in an instructional way, illustrates key concepts for ease of retention, and poses tough questions so readers can problem solve potential scenarios and test their pharmacologic acumen. Written by leading experts in oncopharmacology, this first-of-its kind manual is a “must have” for anyone involved in the basic, translational, or clinical aspects of oncology and hematology including clinicians, pharmacists, nurses, and trainees.

KEY FEATURES:
• In Includes visual depictions of chemical structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents
• Describes how chemotherapy, targeted therapy, immunotherapy, and hormonal therapy work and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other modalities
• Over 100 highly stylized images and numerous comprehensive tables
• Covers challenges related to drug development, drug approval, and regulatory issues in relation to anticancer treatments
• All chapters conclude with clinical pearls and detailed clinical Q&As with descriptive rationales
• Purchase includes access to the ebook for use on most mobile devices or computers

Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies. Beautifully illustrated throughout, each chapter contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book, and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Flow diagrams, clinical tables, and bulleted text further explain important information pertaining to each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring. Organized in an easyto- digest format and replete with detailed images, clinical pearls, and end of chapter Q&As, this evidence-based reference presents all major classes, agents, targets, and approaches to cancer pharmacotherapy. Whether you are a trainee, a clinical scientist, or a clinician in practice, the book is an ideal reference. It presents challenging information in an instructional way, illustrates key concepts for ease of retention, and poses tough questions so readers can problem solve potential scenarios and test their pharmacologic acumen. Written by leading experts in oncopharmacology, this first-of-its kind manual is a "must have" for anyone involved in the basic, translational, or clinical aspects of oncology and hematology including clinicians, pharmacists, nurses, and trainees. KEY FEATURES: Includes visual depictions of chemical structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents Describes how chemotherapy, targeted therapy, immunotherapy, and hormonal therapy work and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other modalities Over 100 highly stylized images and numerous comprehensive tables Covers challenges related to drug development, drug approval, and regulatory issues in relation to anticancer treatments All chapters conclude with clinical pearls and detailed clinical Q&As with descriptive rationales Purchase includes access to the ebook for use on most mobile devices or computers Cancer An Illustrated Manual of Anticancer Drugs provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this pharmacology book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies. Beautifully illustrated throughout, each chapter in this cancer pharmacology guide contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book, and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Flow diagrams, clinical tables, and bulleted text further explain important information pertaining to each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring. Organized in an easy-to-digest format and replete with detailed images, clinical pearls, and end of chapter Q&As, this evidence-based reference presents all major classes, agents, targets, and approaches to oncology pharmacotherapy. Key Anticancer Drug Development : An Introduction / Edward A. Sausville -- Alkylating Agents / Ali Bukhari and Ashkan Emadi -- Antimetabolites : Purine/Pyrimidine Analogs, Asparaginase and Hydroxyurea / Crystal Lu, Judith E. Karp and Ashkan Emadi -- Antimetabolites : Antifolates / Justin Lawson and Edward A. Sausville -- Antimitotics / Edward A. Sausville -- Molecular Pharmacology : DNA Repair, Apoptotic Pathways, CDK Inhibitors / Mira A. Kohorst and Scott H. Kaufmann -- Epigenetic Modulators / Lukasz P. Gondek -- Differentiating Agents and Microenvironment / Gabriel Ghiaur -- Female Hormonal Therapies / Amy Fulton and Katherine H.R. Tkaczuk -- Male Hormonal Therapies / Arif Hussain and Vincent C. O. Njar -- Targeted Therapies (Small Molecules) / Michael G. McCusker, Jr., Katherine A. Scilla, and Christian Rolfo -- Monoclonal Antibodies Including Immunoconjugates and Cytokine-Directed Agents / Alison Duffy and Ciera Patzke -- Immunotherapeutics Including Vaccines, Bispecifics, CAR-T, and Checkpoint Inhibitors / Mark Yarchoan and Elizabeth Jaffee -- Multiple Myeloma as a Paradigm for Multi-Targeted Intervention / Mehmet Kocoglu -- Transplant-Related Agents / Jean Yared and Saurabh Dahiya -- Basic Drug Development With Structural Considerations / Sonia Esparza and Joshua Zeidner -- Integral Components in Development of Clinical Trials : PK/PD, Statistics, and Principles of Rational Combinatorial Therapies / S. Percy Ivy and Richard F. Little -- Drug Approval and Regulatory Issues / Olanrewaju O. Okusanya, Ruby Leong, Matthew D. Thompson, and Donna Przepiorka "We are living in an exciting time for cancer pharmacology, where the fusion of multiple disciplines of basic and clinical science are creating effective, life-prolonging therapies for a growing number of malignancies. Historically, the first anticancer agents targeted molecules that are critical to the overall process of cell replications in both normal and malignant cells and, as such, were relatively non-discriminatory in their cytotoxicity. The revolution in molecular technology that began in the late 1980's is now being brought to bear on the structural design of agents that selectively target tumor-related gene mutations and signaling pathway intermediaries in ways that may augment tumor cell death and spare underlying normal cell populations"-- Provided by publisher