Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention, Volume 1: Biology and Treatment (Cancer Metastasis - Biology and Treatment)

This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology. Ch. 1. Metastatic Cascade, Molecular/cellular Events And New Therapeutic Opportunities -- Ch. 2. The Role Of Integrin-mediated Processes In The Biology Of Metastasis -- Ch. 3. The Role Of Hyaluronan And Its Degradation Products In Tumour Angiogenesis And Metastasis -- Ch. 4. The E-cadherin/catenin Complex In Invasion: The Role Of Ectodomain Shedding -- Ch. 5. Cancer And Cancer Metastasis-related Genes -- Ch. 6. Hepatocyte Growth Factor And Met In Tumour Invasion-metastasis: From Mechanisms To Cancer Prevention -- Ch. 7. Tight Junctions, A Critical Structure In The Control Of Cancer Invasion And Metastasis -- Ch. 8. Bone Marrow Micrometastases Detection And Significance -- Ch. 9. Polyunsaturated Fatty Acids And Their Role In Cancer Invasion And Metastasis -- Ch. 10. Metastatic Endocrine Cancer -- Ch. 11. Prostate Cancer -- Ch. 12. Gastrointestinal Tumours: Cancer Metastasis, Molecular And Cellular Biology -- Ch. 13. Breast Cancer Metastasis -- Ch. 14. The Malignant Lymphomas -- Ch. 15. Cancer Metastasis: Biological And Clinical Aspects, Gynaecological Cancer. Edited By Wen G. Jiang, Robert E. Mansel. Includes Bibliographical References And Index. Includes Bibliographical References And Index. Metastatic Cascade, Molecular/Cellular Events and New Therapeutic Opportunities....Pages 1-17 The Role of Integrin-Mediated Processes in the Biology of Metastasis....Pages 19-54 The Role of Hyaluronan and Its Degradation Products in Tumour Angiogenesis and Metastasis....Pages 55-71 The E-Cadherin/Catenin Complex in Invasion: The Role of Ectodomain Shedding....Pages 73-119 Cancer and Cancer Metastasis-Related Genes....Pages 121-141 Hepatocyte Growth Factor and Met in Tumour Invasion-metastasis: From Mechanisms to Cancer Prevention....Pages 143-193 Tight Junctions, a Critical Structure in the Control of Cancer Invasion and Metastasis....Pages 195-213 Bone Marrow Micrometastases Detection and Significance....Pages 215-224 Polyunsaturated Fatty Acids and Their Role in Cancer Invasion and Metastasis....Pages 225-250 Metastatic Endocrine Cancer....Pages 251-278 Prostate Cancer....Pages 279-296 Gastrointestinal Tumours: Cancer Metastasis, Molecular and Cellular Biology....Pages 297-337 Breast Cancer Metastasis....Pages 339-352 The Malignant Lymphomas....Pages 353-380 Cancer Metastasis: Biological and Clinical Aspects, Gynaecological Cancer....Pages 381-420 Metastasis, the spread of cancer cells to tissues and organs beyond where the tumour is originated and formation of new tumours (secondaries and tertiaries), is the single event that results in death of most of patients with cancer.