Cancer metastasis : molecular and cellular biology, host immune responses, and perspective for treatment

These are the Proceedings of the 2nd International Metastasis Congress of the Metastasis Research Society which took place in the town hall (Stadthalle) of Heidelberg, FRG, in September, 1988. This first Metastasis Congress in the FRG was organized in conjunction with the German Association of Cancer Research (SEK) of the German Cancer Society. The congress topic generated tremendous interest and attracted about 400 scientists from 22 countries. Most participants came from Europe, Israel, and the United States. Why did we organize the Metastasis Congress? Only about 50% of all people who develop some form of cancer are curable. Despite improved patient care and increasingly innovative and effective techniques for diagnosing and treating primary cancers, the development of secondary cancer colonies, i. e. , metastasis, can not be prevented and is the major cause of death. In the Federal Republic of Germany there are still as many as 160 000 cancer patients per year who succumb to their disease, often after periods of terrible suffering, and this overall figure is not improving. Partly because of the complexity of the process, basic research on metastasis has lagged behind other disciplines such as carcino­ genesis and cancer genetics. Metastasis formation involves the ability of malig­ nant cells to invade adjacent tissue and to penetrate into lymphatic or blood circulatory systems, or both, and to spread to near or distant sites to form new tumor colonies. Meanwhile, research on metastasis is receiving much attention. Front Matter....Pages I-XIV Front Matter....Pages 1-1 Metastasis: The Clinical Problem....Pages 3-10 The Nude Mouse Model for Studies of Human Cancer Metastasis....Pages 11-17 Front Matter....Pages 19-19 Tumor Cells Genetically Tagged with Transferred DNA Markers Reveal Evidence for Clonal Dominance of Primary Tumors by Metastatic Subpopulations....Pages 21-26 Oncogenes and Tumor Progression: State of the Art....Pages 27-35 Genetic Analysis of Invasive and Metastatic Capacity in T Lymphoma Cells....Pages 36-41 Transforming Growth Factor-Beta: Possible Roles in Carcinogenesis....Pages 42-47 Altered Gene Expression in Tumor Metastasis: The nm23 Gene....Pages 48-52 Front Matter....Pages 53-53 In Vivo Observations on Tumor Invasion....Pages 55-61 Metastatic Phenotype and Cell Differentiation in Melanoma Cells....Pages 62-67 Front Matter....Pages 69-69 Adhesive, Invasive, and Growth Properties of Organ-Specific Metastatic Cells....Pages 71-85 Importance of Cell Surface Carbohydrates in Tumor Cell Metastasis....Pages 86-91 Cell Shape and the Metastatic Phenotype....Pages 92-97 Cell Surface Plasminogen Activation....Pages 98-107 Adhesion Mechanisms in Lymphoma Invasion and Metastasis....Pages 108-112 The Role of Macrophages in the Regulation of Tumor Growth and Metastasis....Pages 113-117 Front Matter....Pages 119-119 The Influence of Murine and Human Major Histocompatibility Complex Class I Expression on Tumor Growth and Metastasis....Pages 121-128 Identification of Point Mutations in Genes Coding for tum-Antigens. A Step Towards the Understanding of Mouse and Human Tumor-Specific Transplantation Antigens?....Pages 129-135 Recognition of the HLA Class II-Peptide Complex by T cell Receptor: Reversal of MHC Restriction of a T Cell Clone by a Point Mutation in the Peptide Determinant....Pages 136-149 Regulatory Aspects of the Antitumor Immune Response....Pages 150-154 Front Matter....Pages 155-155 Active Specific Immunotherapy with Autologous Tumor Cell Vaccines Modified by Newcastle Disease Virus: Experimental and Clinical Studies....Pages 157-170 Front Matter....Pages 155-155 The Effect of Interferon on Experimental Tumor Metastases....Pages 171-180 Injections of Interleukins Around Tumor-Draining Lymph Nodes: A New Mode of Immunotherapy....Pages 181-185 Autolymphocyte Therapy: An Outpatient, Low-Toxicity Approach to Adoptive Immunotherapy....Pages 186-191 Active Specific Immunotherapy of Colorectal Cancer....Pages 192-198 Review of Experience in Clinical Trials of Specific Active Tumor-Associated Antigen Immunotherapy of Lung Cancer....Pages 199-205 Front Matter....Pages 207-207 Metastasis: Growth and Pathogenesis, Models, and Mechanisms....Pages 209-211 Metastasis: Diagnosis and Targeting, Genetic Changes....Pages 212-215 Metastasis: Adhesion, Lectin-Carbohydrate Interaction, Organotropism, Growth Factors....Pages 216-218 Invasion, Matrix Degradation, Angiogenesis, Motility....Pages 219-221 Metastatic Phenotype and Cell Differentiation....Pages 222-222 Microenvironmental Factors, Hormones, and Signal Transduction....Pages 223-225 Tumor Immunology....Pages 226-229 Immunotherapy Studies....Pages 230-232 Therapy: Chemo-, Hormone- and Radiotherapy, Surgery....Pages 233-235 Front Matter....Pages 237-237 The First Paget-Ewing Award Ceremony....Pages 239-242 Laudatio for Professor Irwing Zeidman....Pages 243-247 Front Matter....Pages 249-249 Surgery, Radiotherapy, Chemotherapy, Hormonal Therapy....Pages 251-256 Bone Marrow Transplantation, Monoclonal Antibodies, Growth Factor Antagonists, Colony-Stimulating Factors....Pages 257-260 Adoptive Immunotherapy, Active Specific Immunotherapy, Biological Response Modifiers....Pages 261-263 Back Matter....Pages 265-269 The contributions in this volume originated at the 2nd International Metastasis Congress held September, 1988, in Heidelberg. Well-known experts from the United States and Europe gathered to exchange information and summarize the status quo in this newly developing field of cancer research. The proceedings of the satellite workshop on clinical perspectives for treatment of metastases are also included Proceedings of the 2nd Int. Conference of the Metastasis Research Society of a Satellite Workshop, Heidelberg, September 26-29, 1988