Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures (Cancer Growth and Progression (13))

This book represents a comprehensive description and evaluation of the most up-to-date approaches to cancer management. Each chapter, prepared by leading basic researchers and clinicians, provides an in depth description of a specific method for cancer management. The chemotherapy section of the book is updated to include the newest drugs as well as those currently in development. Organized by drug class, this section provides the latest information on most drugs, including their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The biological therapy section of the book provides expanded coverage of the currently used cytokines, vaccines, and cell based therapies of cancer. Full consideration is also given to other modern treatment approaches, such as tyrosine kinase inhibitors, inhibitors of tumor angiogenesis, and the transcatheter management of cancer. Current advances in hyperthermia in cancer treatment, hematologic and nutritional support, bone marrow transplantation, pain management and care of the terminally ill patients with cancer are also presented. In summary, this book provides a comprehensive coverage of the current knowledge on the most innovative, systematic and multidisciplinary approaches to the treatment of patients with cancer. Front Matter....Pages i-xv Front Matter....Pages 1-1 Plant-Derived Natural Products as Anticancer Agents....Pages 3-23 The Vinca Alkaloids....Pages 25-37 Taxanes and Epothilones in Cancer Treatment....Pages 39-60 Alkylating Agents....Pages 61-85 Anthracyclines and Anthracenediones....Pages 87-102 Topoisomerase I Inhibitors – The Camptothecins....Pages 103-123 Folate Antagonists....Pages 125-143 Platinum Complexes for the Treatment of Cancer....Pages 145-164 Hormonal Therapy in Cancer....Pages 165-190 Effects of Cancer Chemotherapy on Gonadal Function....Pages 191-214 Targeting the TumorMicroenvironment for Enhancing Chemotherapy in HematologicMalignancies....Pages 215-233 Front Matter....Pages 235-235 Cytokines in the Treatment of Cancer....Pages 237-244 Antibody-Based Therapies for Solid Tumors....Pages 245-256 Cancer Vaccines....Pages 257-284 Adoptive Immunotherapy of Cancer Using Autologous Lymphocytes....Pages 285-294 Oncolytic Virotherapy of Cancer....Pages 295-316 Front Matter....Pages 317-317 Protein Kinase Inhibitors....Pages 319-330 Inhibitors of Tumor Angiogenesis....Pages 331-340 Transcatheter Management of Neoplasms....Pages 341-347 Tumor Stem Cells: Therapeutic Implications of a Paradigm Shift in Multiple Myeloma....Pages 349-362 Front Matter....Pages 363-363 Induced Hyperthermia in the Treatment of Cancer....Pages 365-377 Front Matter....Pages 379-379 Hematologic Support of the Patient with Malignancy....Pages 381-405 Current Status of BoneMarrow Transplantation for Treatment of Cancer....Pages 407-435 Pain Management in Cancer Patients....Pages 437-452 Management of Nausea and Vomiting in Cancer Patients....Pages 453-471 Nutrition in the Management of the Cancer Patient....Pages 473-494 Predictive Value of IFN-γ-Induced Indoleamine 2,3-Dioxygenase (IDO) Expression in Cancer Patients....Pages 495-507 Back Matter....Pages 509-524