Cancer in transplantation : prevention and treatment : proceedings of the 27th Conference on Transplantation and Clinical Immunology, 22-24 May 1995

Malignancies are frequent complications in organ transplantation, mainly as the result of infection with certain viruses and of long-term immunosuppression. The epidemiology confirms that the increased incidence concerns certain cancers, especially HIV-related skin cancers and EBV-related lymphoproliferative malignancies. This book covers all currently available information on this important topic of the relationships between transplantation and malignancies: preexisting cancers, posttransplant cancers, their etiology and pathophysiology, their prevention and treatment. A significant part of the volume is devoted to prophylaxis, early detection and modern forms of therapy in posttransplant lymphomas. As a conclusion of all these new data, the theory of immunosurveillance deserves to be significantly modified. Front Matter....Pages i-xv Front Matter....Pages 1-1 Epidemiology of cancer in transplant Patients....Pages 3-15 Multicenter analysis of posttransplant malignancies....Pages 17-23 German multicenter analysis of malignancies following renal replacement therapy in children....Pages 25-30 Malignancies transmitted with the transplant....Pages 31-38 Front Matter....Pages 39-39 Outcome of preexisting urological tumors in dialysis and in renal transplant recipients....Pages 41-46 Screening for breast and gynecologic carcinomas in transplant patients....Pages 47-51 Results of renal transplantation for Wilms’ tumour....Pages 53-55 Prevention of recurrence after liver transplantation for hepatocellular carcinoma....Pages 57-61 Front Matter....Pages 63-63 Skin cancers in organ transplant recipients....Pages 65-72 Kaposi’s sarcoma in organ transplantation (Lyon Experience, 1965–1995)....Pages 73-80 Human T-cell leukemia virus type I (HTLV-I) and transplantation....Pages 81-87 Hepatitis B virus and primary liver cancer in Hepatitis B surface antigen positive and negative patients....Pages 89-113 Malignancies in patients with pancreas and kidney transplants....Pages 115-119 Front Matter....Pages 121-121 Cancer risk factors in transplantation....Pages 123-129 Risk of cancer in transplant patients treated with recombinant growth hormone....Pages 131-133 Malignancies in transplant patients under cyclosporine treatment for more than 10 years....Pages 135-139 Risk of malignancies in patients treated with Sandimmun ® for autoimmune diseases....Pages 141-148 De novo malignancies following renal transplantation....Pages 149-158 Front Matter....Pages 159-159 Virus induced cancer: The lesson of Epstein—Barr virus....Pages 161-175 Nonlymphoid Epstein-Barr virus induced neoplasms after organ transplantation....Pages 177-187 Front Matter....Pages 159-159 The Epstein-Barr virus latency and reactivation....Pages 189-199 Early detection of EBV infection and meaning in transplant patients....Pages 201-207 Lymphomas in the Scid/Hu mice: Effect of EBV on human B-cells in vivo....Pages 209-213 Front Matter....Pages 215-215 Types of lymphomas in transplant and other immunosuppressed patients....Pages 217-222 Production and role of cytokines in lymphoproliferations of immune deficiency....Pages 223-228 Interleukin 10 and non Hodgkin’s lymphomas....Pages 229-241 Serum monoclonal immunoglobulins in renal transplant recipients: A study using high resolution electrophoresis and western blotting....Pages 243-248 Increased risk of lymphoproliferative disorders following the use of OKT3: Association with cumulative dose....Pages 249-258 Clinical characteristics of lymphoproliferations after renal transplantation. Nantes experience....Pages 259-266 Therapeutic issues in lymphoproliferative disorders: Treatment and outcome of 28 cases observed in a single center....Pages 267-278 Anti-B-cell MAb therapy of transplant-related lymphoproliferative diseases....Pages 279-288 Antibody treatment of lymphoma: experience and prospects....Pages 289-298 Idiotypic vaccination against low grade follicular B cell lymphoma....Pages 299-304 Front Matter....Pages 305-305 Immunosurveillance revisited....Pages 307-310 Front Matter....Pages 311-311 Circulating Plasmacytoid Cells : An Early Marker of Post-Transplant Lymphoproliferative Disorders....Pages 315-315 Lymphoproliferative Disease in Heart Transplant Patients....Pages 316-316 Successful Multi-Modality Therapy of Monoclonal Lymphoproliferative Disease in a Lung Transplant Recipient....Pages 317-317 Lymphoproliferative Disease Localized in the Renal Allograft. French Multicentric Study....Pages 318-318 Prevention of Skin Cancer During Acitretin Therapy in Renal-Transplant Recipients; a Placebo-Controlled Study....Pages 321-321 Skin Cancer after Renal Transplantation: Efficacy of Immunosuppressive Monotherapy on Relapse Rate....Pages 322-322 Front Matter....Pages 311-311 Dermatological Lesions in Kidney Graft Recipients....Pages 323-323 Skin Cancers and Precancerous Lesions in Renal Grafts....Pages 324-324 De Novo Malignancies after Kidney Transplantation....Pages 327-327 Neoplastic diseases after liver transplantation....Pages 328-328 «De Novo» Carcinoma after Liver Transplant (L.T.)....Pages 329-329 Primary Bronchogenic Carcinoma in Transplant Recipient....Pages 330-330 Misdiagnosed Malignancy in Transplanted Organs....Pages 331-331 Nephrogenic Adenoma (NA) of the Bladder in Renal Transplanted Patients....Pages 332-332 Transmission of Renal Carcinomas with Cadaveric Donor Kidneys: A Five Years Follow Up....Pages 333-333 Tumors after Renal Transplantation....Pages 334-334 The Incidence of Malignancy in the Population of 1.280 Kidney Transplantations - A Complete Single Center Analysis....Pages 335-335 The Malignancies after Kidney Transplantation in Thailand....Pages 336-336 Kaposi’s Sarcoma in Kidney Transplant Recipients....Pages 337-337 Malignancy in Kidney Transplant Patients....Pages 338-338 De Novo Malignancy Following Orthotopic Liver Transplantation (OLT) for Alcoholic Cirrhosis (AC)....Pages 339-339 Sequential Assessment of Peripheral B-Cells and Detection of Viral Infections in Kidney Recipients....Pages 343-343 HCV Chronic Infection in HD (Hemodialysed) Candidates to KT (Kidney Transplant). Influence of Virus C Genotypes on Response to IFN Treatment....Pages 344-344 Essential Fatty Acid Deficiency in Children with Extrahepatic Biliary Atresia: Influence of Orthotopic Liver Transplantation....Pages 345-345 Gammapathies in Transplanted Children: 18 Month Follow-Up of 39 Patients by Quarterly Immunofixation....Pages 346-346 Unusual infections after pulmonary transplantation....Pages 347-347 Front Matter....Pages 311-311 Transient Hyperphosphatasemia after Liver Transplantation in Infancy....Pages 348-348 Gilbert’s Syndrome. A Possible Cause of Hyperbilirubinemia after Orthotopic Liver Transplantation....Pages 349-349 Disseminated Tuberculosis with Pulmonary Miliary and Pharyngeal Localisation in 2 Kidney Transplanted Patients....Pages 350-350 Successful Fibrinolysis Following Thrombosis in a Grafted Kidney Artery....Pages 351-351 Atypical Urinary Citology in Kidney Transplant Recipients....Pages 352-352 Interest of Radionuclide Imaging in Diagnosis of a Case of non Evident Urinary Fistula after Renal Transplantation....Pages 353-353 Discontinuation of Immunosuppressive Treatment after Kidney Transplantation....Pages 354-354 Back Matter....Pages 355-356