Cancer Cytogenetics : Chromosomal and Molecular Genetic Aberrations of Tumor Cells

The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. New contributors reflecting broader international authorship and even greater expertise Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date Now produced in full color for enhanced clarity Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible The First Three Editions Of This Acclaimed Book Presented A Much-needed Conceptual Synthesis Of This Rapidly Moving Field. Now, Cancer Cytogenetics, Fourth Edition, Offers A Comprehensive, Expanded, And Up-to-date Review Of Recent Dramatic Advances In This Area, Incorporating A Vast Amount Of New Data From The Latest Basic And Clinical Investigations. New Contributors Reflecting Broader International Authorship And Even Greater Expertise Greater Emphasis Throughout On The Clinical Importance And Application Of Information About Cytogenetic And Molecular Aberrations Includes A Complete Coverage. How It All Began : Cancer Cytogenetics Before Sequencing / Felix Mitelman, Sverre Heim -- Cytogenetic Methods / David Gisselsson -- Cytogenetic Nomenclature / Sverre Heim, Felix Mitelman -- Nonrandom Chromosome Abnormalities In Cancer : An Overview / Sverre Heim, Felix Mitelman -- From Chromosomes To Genes : Searching For Pathogenetic Fusions In Cancer / Ioannis Panagopoulos -- Acute Myeloid Leukemia / Bertil Johansson, Christine Harrison -- Myelodysplastic Syndromes / Harold J. Olney, Michelle M. Le Beau -- Chronic Myeloid Leukemia / Thoas Fioretos -- Chronic Myeloproliferative Neoplasms / Peter Vandenberghe, Lucienne Michaux -- Acute Lymphoblastic Leukemia / Christine Harrison, Bertil Johansson -- Mature B- And T-cell Neoplasms And Hodgkin Lymphoma / Reiner Siebert, Sietse M. Aukema -- Tumors Of The Upper Aerodigestive Tract / Susanne M. Gollin -- Tumors Of The Lung / Penny Nymark, Eeva Kettunen, Sakari Knuutila -- Tumors Of The Digestive Tract / Georgia Bardi, Sverre Heim -- Tumors Of The Urinary Tract / Paola Dal Cin -- Tumors Of The Breast / Manuel R. Teixeira, Nikos Pandis, Sverre Heim -- Tumors Of The Female Genital System / Francesca Micci, Sverre Heim -- Tumors Of The Male Genital Organs / Manuel Teixeira, Sverre Heim -- Tumors Of Endocrine Glands / Jörn Bullerdiek And David Gisselsson -- Tumors Of The Nervous System / Petter Brandal, Sverre Heim -- Tumors Of The Eye / Karen Sisley -- Tumors Of The Skin / Fredrik Mertens, Felix Mitelman, Sverre Heim -- Tumors Of Bone / Fredrik Mertens, Nils Mandahl -- Soft Tissue Tumors / Nils Mandahl, Fredrik Mertens. Edited By Sverre Heim, Felix Mitelman. Includes Bibliographical References And Index. Mode Of Access: World Wide Web. Over the past decade, cancer cytogenetics has become widely recognized both as a basic research tool for investigations of tumor biology and a clinical methodology providing vital insights into cancer development and progression. Written by two leading experts, Cancer Cytogenetics, Second Edition provides an authoritative description of neoplastic processes at the chromosomal level of genomic organization. The book opens with a summary of cytogenetic methods and terminology, then reviews the key aspects of chromosomal abnormalities in cancer. The remainder of the book is devoted to the karyotypic and molecular genetic characteristics of specific neoplastic disorders and their clinical implications. Included in these sections are eleven entirely new chapters focusing on different types of non-hematologic neoplasms. This extensive expansion from the single-chapter coverage of the first edition was necessitated by a veritable explosion of knowledge in the field of solid tumor cytogenetics. . Specific topics in the Second Edition include: acute and chronic myeloproliferative disorders; myelodysplastic syndromes; acute and chronic lymphoproliferative disorders; malignant lymphomas; and solid tumors of the respiratory, digestive, and urinary tracts; breast, genital, endocrine, and nervous systems; eye, skin, and bone; and soft tissue. This Second Edition of Cancer Cytogenetics is a valuable resource for researchers in a wide range of fields, including cytogenetics, medical and molecular genetics, cellular and molecular biology, oncology, and hematology. With its complete coverage of the cytogenetic mechanisms underlying neoplasia, this text will also be an indispensable reference for all clinicians involved in the diagnosis and treatment of cancer patients.