Cancer Chemotherapy and Biotherapy: Principles And Practice (Cancer Chemotherapy and Biotherapy (Chabner))

Updated to include the newest drugs and those currently in development, this Fourth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition provides expanded coverage of monoclonal antibodies, molecularly targeted drugs, vaccines, cell based therapies, growth factors, and pharmacogenetics. Clinical strategies / Bruce Chabner Preclinical aspects of cancer drug discovery / Ed Sausville ... [et al.] Pharmacokinetics / Jerry Collins Infertility / Angela Bradbury, Richard Schilsky Carcinogenesis / Larry Blaszkowsky Antifolates / Carmen Allegra, Brian Monahan 5 fluoropyrimidine / Jean Grem Cytidine analogues / David Ryan Purine analogues / Kenneth Hande Hydroxyurea / Bruce Chabner Antimicrotuble agents / Eric Rowinsky Alkylating agents/clinical & high dose / Roy Jones, Ken Tew Nonclassical agents / Henry Friedman Platinum analogues / Ed Reed Bleomycin / Bruce Chabner Antibiotics / Kees Nooter, Jaap Verweij, Edwin Willems Topo I: inhibitors / Alex Sparreboom, William Zamboni Topo II: anthracyclines / Jim Doroshow Topo II: epipodophylotoxins / Yves Pommier, Francios Goldwasser L-asparaginase / Bruce Chabner Pharmacology of CNS agents / Jeff Supko FDA approval / Thomas Roberts Catheter and complications / David Kuter, Rachel Rosovsky Pharmacogenetics / Robert Diasio, Jeanne Fourie New agents / Louise Grochow Bisphosphonates / Matthew Smith Thalidomide / Paul Richardson Inhibitors of tumor angiogenesis / William Gradishar, Anaadriana Zakarija Proteosome inhibitors / Owen O'Connor Molecular targeted drugs-growth factor receptor inhibitors / Jeff Clark Monoclonal antibody therapies / David Scheinberg Interferon / Danield Linder, Earnest Borden Adoptive therapies / Carl June Vaccines / Glenn Dranoff Hematopoietic growth factors / William Petros Interleukins / Gheath Alatrash ... [et al.] Hormonal therapy for breast cancer and prostate / Peter Lebowitz, Sandra Swain, Steven Balk. Comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organised by drug class, the book provides the latest information on all drugs and biological agents--their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition provides expanded coverage of monoclonal antibodies, molecularly targeted drugs, vaccines, cell based therapies, growth factors, and pharmacogenetics Updated to include the newest drugs and those currently in development, this Fourth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organised by drug class, the book provides the latest information on all drugs and biological agents-their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations Editors Bruce A. Chabner, Dan L. Longo. Includes Bibliographical References And Index. Also Available In An Electronic Version.