Cancer Chemoprevention: Volume 1: Promising Cancer Chemopreventive Agents (Cancer Drug Discovery and Development)

Much progress has been made in discovering and developing agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis. In Cancer Chemoprevention, Volume 1: Promising Cancer Chemopreventive Agents, leading researchers in the discovery and development of chemopreventives comprehensively survey all aspects of these emerging therapeutics. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The classes vary widely in terms of their stages of development as chemopreventives and include both extensively studied groups and those with recently identified potential based on such mechanistic data as protein kinase inhibition. Attention is also devoted to nutriceuticals (food-derived agents) because of their high promise for prevention in healthy populations. The overall focus is on molecular targets and mechanisms. A second volume, Strategies for Cancer Chemoprevention, describes the exciting methodologies that are accelerating progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs. Up-to-date and highly practical, Cancer Chemoprevention, Volumes 1 & 2, offer oncologists, pharmacologists, medicinal chemists, and toxicologists a comprehensive reference survey on the identification of promising cancer chemopreventive agents that will help stimulate further research and the development of novel approvable drugs. Front Matter....Pages i-xvi Front Matter....Pages 1-1 Inducers of Enzymes That Protect Against Carcinogens and Oxidants....Pages 3-20 Chemoprevention by Isothiocyanates....Pages 21-35 Antigenotoxic and Cancer Preventive Mechanisms of N -Acetyl- l -Cysteine....Pages 37-67 Modifiers of Cytochrome(s) P450....Pages 69-84 Front Matter....Pages 85-85 Antiinflammatories and Chemoprevention....Pages 87-105 Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention....Pages 107-113 Lipoxygenases as Targets for Cancer Prevention....Pages 115-131 Inducible Nitric Oxide Synthase as a Target for Chemoprevention....Pages 133-151 Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol....Pages 153-167 Chemoprevention of Cancer by Curcumin....Pages 169-175 Prostacyclin and Lung Cancer Chemoprevention....Pages 177-191 Front Matter....Pages 193-193 Nuclear Receptor Superfamily....Pages 195-208 The Retinoids and Cancer Chemoprevention....Pages 277-288 Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs....Pages 291-300 Prostate Cancer Chemoprevention....Pages 211-218 Searching For SARA....Pages 219-228 Aromatase Inhibitors as Chemopreventives of Breast Cancer....Pages 231-243 Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators....Pages 245-256 Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs....Pages 259-274 Front Matter....Pages 301-301 ras Oncogene Inhibitors....Pages 303-316 Front Matter....Pages 301-301 The Potential of EGFR-Targeted Agents in Cancer Prevention....Pages 317-324 Pharmacological Intervention With Multistep Oncogenesis....Pages 325-337 Therapeutic Strategies Targeting Polyamines....Pages 339-357 The Role of Phytoestrogens as Cancer Prevention Agents....Pages 359-369 Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids....Pages 371-378 Development of an Inhibitor of raf Kinase....Pages 379-382 Abnormalities in Cell Cycle Control in Human Cancer and Their Relevance to Chemoprevention....Pages 383-399 Select Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and Chemotherapy....Pages 401-416 Front Matter....Pages 417-417 Chemoprevention by Fruit Phenolic Compounds....Pages 419-435 Tea Polyphenols as Cancer Chemopreventive Agents....Pages 437-449 Vitamin E as a Cancer Chemopreventive Agent....Pages 451-484 Vitamin C as a Cancer Chemopreventive Agent....Pages 485-510 Carotenoids....Pages 511-523 Lycopene, a Dietary Cancer Chemopreventive Agent....Pages 525-535 Not All Chemopreventive Selenium Compounds are Created Equal....Pages 537-545 Calcium....Pages 547-558 Folate and Cancer Chemoprevention....Pages 559-582 Conjugated Linoleic Acid as a Tumor Preventive Agent....Pages 583-590 Chemopreventive Effects of Omega-3 Fatty Acids....Pages 591-608 Front Matter....Pages 609-609 Tumor Angiogenesis as a Target for Early Intervention and Cancer Prevention....Pages 611-633 Front Matter....Pages 609-609 Proteasome Inhibitors in Cancer Therapy....Pages 635-642 Modulation of DNA Methylation for the Treatment and Prevention of Cancer....Pages 643-658 Targeting Histone Deacetylase as a Strategy for Cancer Prevention....Pages 659-678 Back Matter....Pages 679-697

Much progress has been made in discovering and developing agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis. In Cancer Chemoprevention, Volume 1: Promising Cancer Chemopreventive Agents, leading researchers in the discovery and development of chemopreventives comprehensively survey all aspects of these emerging therapeutics. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The classes vary widely in terms of their stages of development as chemopreventives and include both extensively studied groups and those with recently identified potential based on such mechanistic data as protein kinase inhibition. Attention is also devoted to nutriceuticals (food-derived agents) because of their high promise for prevention in healthy populations. The overall focus is on molecular targets and mechanisms. A second volume, Strategies for Cancer Chemoprevention, describes the exciting methodologies that are accelerating progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.

Up-to-date and highly practical, Cancer Chemoprevention, Volumes 1 & 2, offer oncologists, pharmacologists, medicinal chemists, and toxicologists a comprehensive reference survey on the identification of promising cancer chemopreventive agents that will help stimulate further research and the development of novel approvable drugs.

A comprehensive reference survey on the identification and development of promising cancer chemopreventive agents that will help stimulate further novel research and new approvable drugs. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The overall focus is on molecular targets and mechanisms. A second volume, Strategies in Chemoprevention, describes the exciting methodologies that will accelerate progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.

Accompanying CD-ROM in pocket at end of v. 2 contains a compact e-book version of v. 2.