Cancer and Zebrafish: Mechanisms, Techniques, and Models (Advances in Experimental Medicine and Biology Book 916)

"This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system"--Publisher's description Front Matter....Pages i-xii Front Matter....Pages 1-1 Uncharted Waters: Zebrafish Cancer Models Navigate a Course for Oncogene Discovery....Pages 3-19 The Toolbox for Conditional Zebrafish Cancer Models....Pages 21-59 Approaches to Inactivate Genes in Zebrafish....Pages 61-86 Tumor Suppressors in Zebrafish: From TP53 to PTEN and Beyond....Pages 87-101 Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish....Pages 103-124 Genomic Approaches to Zebrafish Cancer....Pages 125-145 Transcriptomic Analyses in Zebrafish Cancer Models for Global Gene Expression and Pathway Discovery....Pages 147-168 Zebrafish Discoveries in Cancer Epigenetics....Pages 169-197 Lymphatics, Cancer and Zebrafish....Pages 199-218 In Vivo Imaging of Cancer in Zebrafish....Pages 219-237 Imaging Cancer Angiogenesis and Metastasis in a Zebrafish Embryo Model....Pages 239-263 Allograft Cancer Cell Transplantation in Zebrafish....Pages 265-287 The Zebrafish Xenograft Platform: Evolution of a Novel Cancer Model and Preclinical Screening Tool....Pages 289-314 Automation of Technology for Cancer Research....Pages 315-332 Front Matter....Pages 333-333 Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights....Pages 335-369 Zebrafish Rhabdomyosarcoma....Pages 371-389 Baiting for Cancer: Using the Zebrafish as a Model in Liver and Pancreatic Cancer....Pages 391-410 Focusing the Spotlight on the Zebrafish Intestine to Illuminate Mechanisms of Colorectal Cancer....Pages 411-437 Zebrafish Melanoma....Pages 439-450 Neuroblastoma and Its Zebrafish Model....Pages 451-478 Front Matter....Pages 333-333 Zebrafish Germ Cell Tumors....Pages 479-494 Malignant Peripheral Nerve Sheath Tumors....Pages 495-530 Xiphophorus and Medaka Cancer Models....Pages 531-552 "This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system."--[Source inconnue]