Calcium, vitamin D, and prevention of colon cancer : Workshop : Papers

These proceedings were published as a result of a workshop sponsored by the Chemoprevention Branch of the National Cancer Institute. The workshop covered a range of topics including calcium and vitamin D in human nutrition; epidemiologic relationships betweencalcium, vitamin D, and colon cancer; the biology of calium and vitamin D at the tissue and cellular level; and enimal and human studies investigating the potential for prevention of colon cancer with calcium and vitamin D. Content: Introduction. Presenters and Planning Committee Members. CALCIUM AND VITAMIN D IN HUMAN NUTRITION. Calcium and Vitamin D in Human Nutrition (Robert P. Heaney, M.D., F.A.C.P.). Calcium Switches, Cell Cycles, Differentiation, and Death (James F. Whitfield, Ph.D.). EPIDEMIOLOGY: RELATIONSHIPS BETWEEN CALCIUM AND VITAMIN D INTAKE AND COLON CANCER. Colon Cancer Parallels Rickets (Cedric F. Garland, Dr.P.H., Frank C. Garland, Ph.D., and Edward D. Gorham, M.P.H.). Calcium and Colon Cancer in Los Angeles County (Ruth K. Peters, Sc.D., Thomas M. Mack, M.D., David H. Garabrant, M.D., David M. Homa, and Malcolm C. Pike, Ph.D.). Calcium and Colon Cancer in Utah (Martha L. Slattery, Ph.D., M.P.H., and Ann W. Sorenson, Ph.D.). BIOLOGY OF CALCIUM AND VITAMIN D AT THE CELLULAR AND TISSUE LEVEL. Colonic Hyperplasia and Hyperproliferation Induced in Rodents by a Nutritional Stress Diet Containing 4 Factors of the Western Human Diet: High Fat and Phosphate, Low Calcium and Vitamin D (H.L. Newmark, M.S. and M. Lipkin, M.D.). Use of Human Colonic Epithelial Cells in Tissue Culture to Study Mechanisms of Calcium Protection (Eileen A. Friedman, Ph.D.). Discussion of Presentation by Dr. Gary Stoner. ANIMAL STUDIES: PREVENTION OF COLON CANCER WITH CALCIUM AND VITAMIN D. The Inhibitory Effect of Calcium on Colorectal Cytokinetics and Carcinogenesis (R.C.N. Williamson, M.D., F.R.C.S., M.G. Thomas, Ch.M., F.R.C.S., and G.V.N. Appleton, Ch.M., F.R.C.S.). Calcium and Vitamin D Effects on Tumor Promotion in Rat Colon and Mouse Skin (Barbara C. Pence, Ph.D.). Effects of Bile Acids and Sterols on Animal Models of Colorectal Cancer (Bertram I. Cohen, Ph.D. and Erwin H. Mosbach, Ph.D.). Dietary Calcium, Phosphate and Vitamin D in Relation to Mammary Carcinogenesis (Kenneth K. Carroll, Ph.D., Lisa A. Eckel, H.B.S.C., Laurence J. Fraher, Ph.D., Jaroslav V. Frei, M.D., Ph.D., F.R.C.P. (c), and Harold Newmark, M.S.). Effect of Dietary Calcium on Azoxymethane-Induced Intestinal Carcinogenesi s in Male F344 Rats Fed High-Fat Diets (Daniel J. Skrypec, Ph.D.). HUMAN STUDIES: POTENTIAL FOR PREVENTION OF COLON CANCER WITH CALCIUM AND VITAMIN D. Short-Term Calcium Intervention Studies, in Animals and Humans, Using Epithelial Proliferation as Biomarker of Response. The Initiation of a Calcium Intervention Trial in Adenoma Patients (Paul Rozen, M.D.). Calcium Effects in the Inhibition of the Initiation, Promotion, and Progression Phases of Colon Carcinogenesis and in Short-Term Trials in Humans (Michael J. Wargovich, Ph.D., Allan Baer, Ph.D., and Bernard Levin, M.D.). Patterns of Gene Expression Tthat Characterize Mucosa at Risk for Development of Colorectal Cancer (Leonard H. Augenlicht, Ph.D., Barbara Heerdt, Ph.D., Sharon Molinas, M.D., and Martin Lipkin, M.D.). Cytoarchitectural Response and Expression of c-fos/p52 Genes During Enhancement of Butyrate-Initiated Differentiation of Human Colon Carcinoma Cells by 1,25-Dihydroxyvitamin D3 and Its Analogs (Paul J. Higgins, P h.D. and Yoko Tanak These proceedings were published as a result of a workshop sponsored by the Chemoprevention Branch of the National Cancer Institute. It covered a range of topics such as epidemiologic relationships between calcium, vitamin D, and colon cancer; and the biology of calium and vitamin D at the tissue and cellular level.