Calcium Signaling (Advances in Experimental Medicine and Biology Book 740)

Calcium signaling contains a unique selection of chapters that cover a wide range of contemporary topics in this ubiquitous and diverse system of cell signaling. This book has the flavor of a primary text book, but it is much more than that. It covers topics ranging from the fundamental aspects of calcium signaling to its clinical implications, in a thoughtful and comprehensive way. It discusses cutting edge researches, and critical issues at depth, and it presents many testable hypotheses for future research. It includes the theoretical and the methodological topics as well as topics related to mathematical modeling, and simulations. If you want to read about calcium signaling in different mammalian cells, oocytes, Zebrafishes, and even in plants, in one and the same book, then this book will not disappoint you. From the beginners to the experts in the field of calcium signaling, everybody will find something useful in this very timely book. Front Matter....Pages i-xiii The Regulation of a Cell’s Ca 2+ Signaling Toolkit: The Ca 2+ Homeostasome....Pages 1-25 Methods to Detect Ca 2+ in Living Cells....Pages 27-43 Development and Optimization of FLIPR High Throughput Calcium Assays for Ion Channels and GPCRs....Pages 45-82 Two-Photon Calcium Imaging in the Intact Brain....Pages 83-102 Signaling Through the Extracellular Calcium-Sensing Receptor (CaSR)....Pages 103-142 Ca 2+ Signaling: An Outlook on the Characterization of Ca 2+ Channels and Their Importance in Cellular Functions....Pages 143-157 Ryanodine Receptor Calcium Release Channels: An Evolutionary Perspective....Pages 159-182 Techniques and Methodologies to Study the Ryanodine Receptor at the Molecular, Subcellular and Cellular Level....Pages 183-215 Ryanodine Receptor Physiology and Its Role in Disease....Pages 217-234 Phospholipase C....Pages 235-254 Inositol 1,4,5-Trisphosphate and Its Receptors....Pages 255-279 The Discovery and Structural Investigation of the IP 3 Receptor and the Associated IRBIT Protein....Pages 281-304 Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores....Pages 305-323 NAADP on Target....Pages 325-347 Store-Operated Ca 2+ Entry....Pages 349-382 Structure, Regulation and Biophysics of I CRAC , STIM/Orai1....Pages 383-410 Mitochondria-Associated Membranes (MAMs) as Hotspot Ca 2+ Signaling Units....Pages 411-437 Calcium Around the Golgi Apparatus: Implications for Intracellular Membrane Trafficking....Pages 439-460 Calcium Binding Proteins....Pages 461-482 Cytoplasmic Calcium Buffering....Pages 483-498 Elementary Calcium Release Events from the Sarcoplasmic Reticulum in the Heart....Pages 499-509 Calcium Oscillations and Pacemaking....Pages 511-520 Calcium Oscillations and Waves in Cells....Pages 521-529 Calcium Signaling: From Single Channels to Pathways....Pages 531-551 Simulation Strategies for Calcium Microdomains and Calcium-Regulated Calcium Channels....Pages 553-567 Combined Computational and Experimental Approaches to Understanding the Ca 2+ Regulatory Network in Neurons....Pages 569-601 α7 Nicotinic ACh Receptors as a Ligand-Gated Source of Ca 2+ Ions: The Search for a Ca 2+ Optimum....Pages 603-638 The Biology of Protein Kinase C....Pages 639-661 The Role of C2 Domains in PKC Signaling....Pages 663-683 Ca 2+ /Calmodulin-Dependent Protein Kinase II (CaMKII) in the Heart....Pages 685-702 The Role of Molecular Regulation and Targeting in Regulating Calcium/Calmodulin Stimulated Protein Kinases....Pages 703-730 Calcium Sensing in Exocytosis....Pages 731-757 Regulation of Voltage-Gated Calcium Channels by Synaptic Proteins....Pages 759-775 Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels....Pages 777-794 Calcium Signaling in Vascular Smooth Muscle Cells: From Physiology to Pathology....Pages 795-810 Calcium and Endothelium-Mediated Vasodilator Signaling....Pages 811-831 Calcium Signaling in Cerebral Vasoregulation....Pages 833-858 Ca 2+ Signaling Mechanisms in Bovine Adrenal Chromaffin Cells....Pages 859-872 Calcium Stores in Vertebrate Photoreceptors....Pages 873-889 Stem Cells and Calcium Signaling....Pages 891-916 Calcium Signaling in Osteoclast Differentiation and Bone Resorption....Pages 917-932 Calcium Signaling in Renal Tubular Cells....Pages 933-944 Calcium in Epidermis....Pages 945-953 Calcium Signaling in Mast Cells: Focusing on L-Type Calcium Channels....Pages 955-977 Proteinase-Activated Receptors (PARs) and Calcium Signaling in Cancer....Pages 979-1000 Mechanosensory Calcium Signaling....Pages 1001-1015 Role Ca 2+ in Mechanisms of the Red Blood Cells Microrheological Changes....Pages 1017-1038 Calcium Imaging in the Zebrafish....Pages 1039-1071 Calcium Signaling in Xenopus oocyte ....Pages 1073-1094 Calcium Oscillations, Oocyte Activation, and Phospholipase C zeta....Pages 1095-1121 Nuclear Calcium Signaling and Its Involvement in Transcriptional Regulation in Plants....Pages 1123-1143 Remodeling of Calcium Handling in Human Heart Failure....Pages 1145-1174 Proarrhythmic Atrial Calcium Cycling in the Diseased Heart....Pages 1175-1191 Neuronal Calcium Signaling and Alzheimer’s Disease....Pages 1193-1217 Voltage-Gated Ca 2+ Channel Mediated Ca 2+ Influx in Epileptogenesis....Pages 1219-1247 Back Matter....Pages 1249-1267 This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to oocytes, zebrafish and plants. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative "This volume ... [explores] topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to oocytes, zebrafish and plants. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative." --Excerpt from publisher's description Annotation. This volume covers topics ranging from fundamental aspects of calcium signaling to its clinical implications, in a thoughtful and comprehensive way. It includes discussion of calcium signaling in different mammalian cells, oocytes, zebrafishes and even in plants