Calcium In Drug Actions (handbook Of Experimental Pharmacology)

The Editorial Board and the Publishers of the Handbook of Experimental Pharmacology wish to express their profound grief at the untimely death of Professor Peter Baker. Aware of his international recognition as an expert on the ubiquitous role of calcium in physiological processes and their pharma­ cological control, the Board was gratified when Professor Baker accepted its invitation to edit a new Handbook volume on "Calcium in Drug Actions". He went about this task with his usual energy and effectiveness so that, in the few months before his unexpected death, Professor Baker had mustered his distinguished contributors, got them to provide their manuscripts, and seen almost the entire material into the press. This achievement is all the more remarkable when one bears in mind the extraordinary number of his other commitments during the same time; they are mentioned in Sir Alan Hodgkin's preface to this volume. With so many other professional and personal responsibilities upon him, the Board of the Handbook wishes to record its grateful appreciation for the admirable way in which Professor Baker took on and carried out the additional work of bringing this fine book into existence; and the Board wishes it to be dedicated to the memory of Professor Peter Frederick Baker. The Editorial Board: G. V. R. BORN, P. CUATRECASAS, H. HERKEN, A. Front Matter....Pages I-XXVI The Multiple Physiological Roles of Calcium: Possible Sites for Pharmacological Intervention....Pages 1-6 Front Matter....Pages 7-7 Chemical Factors Determining the Affinity of a Receptor for Calcium....Pages 9-29 Troponin C and Calmodulin as Calcium Receptors: Mode of Action and Sensitivity to Drugs....Pages 31-56 Ligand-Binding Sites on Calmodulin....Pages 57-87 Calcium Channels as Drug Receptors....Pages 89-114 The Chemistry of Calcium Channel Agonists and Antagonists....Pages 115-133 The Apamin-Sensitive Ca 2+ -Dependent K + Channel: Molecular Properties, Differentiation, Involvement in Muscle Disease, and Endogeneous Ligands in Mammalian Brain....Pages 135-145 Drug Effects on Plasma Membrane Calcium Transport....Pages 147-162 Development of Inhibitors of Sodium, Calcium Exchange....Pages 163-183 The Effect of Ruthenium Red and Other Agents on Mitochondrial Calcium Metabolism....Pages 185-198 Pharmacology of Calcium Uptake and Release from the Sarcoplasmic Reticulum: Sensitivity to Methylxanthines and Ryanodine....Pages 199-216 Effect of Lithium in Stimulus — Response Coupling....Pages 217-240 Phorbol Esters and Protein Kinase C....Pages 241-252 Front Matter....Pages 253-253 Drugs Acting on Calcium Channels....Pages 255-274 Calcium and Synaptic Function....Pages 275-304 Some New Questions Concerning the Role of Ca 2+ in Exocytosis....Pages 305-338 Exo-Endocytosis: Mechanisms of Drug and Toxin Action....Pages 339-359 Pharmacology of Calcium Metabolism in Smooth Muscle....Pages 361-382 Drugs Affecting Cardiac Calcium Metabolism....Pages 383-410 Hormonal Control of Extracellular Calcium....Pages 411-439 Front Matter....Pages 253-253 Bisphosphonates: A New Class of Drugs in Diseases of Bone and Calcium Metabolism....Pages 441-466 Calcium and Hypertension....Pages 467-487 Front Matter....Pages 489-489 Calcium Chelators and Calcium Ionophores....Pages 491-507 Lead-Calcium Interactions and Lead Toxicity....Pages 509-525 Alkaline Earths, Transition Metals, and Lanthanides....Pages 527-546 Back Matter....Pages 547-567 The volume contains an up-to-the-minute account of direct investigations into the role of calcium ions in cellular function. Information on the operation of calcium channels in the plasma membrane and the release of calcium from intracellular stores, especially by recently discovered inositol phosphates and the long investigated methyl xanthines are all dealt with at a level of the most modern methodology. The role of the ubiquituos Ca-Na exchanger, Ca-ATPase and calcium binding proteins are given detailed coverage with an account of chemical agents modifying these functions. Details of the interactions of Ca with known receptors such as calmodulin, troponin C, Ca sensitive ion channels and protein kinase C are all given expert treatment. This volume would not be complete without consideration of the chemistry of the Ca ion itself, ions which can substitute for Ca, in some instances producing toxic effects such as with lead, and the role of Ca in bone formation. The Multiple Physiological Roles of Calcium: Possible Sites for Pharmacological Intervention Calcium Receptors and Calcium Metabolism Calcium and Physiological Function Drugs and Toxicological Agents that Either Mimic Calcium or Elements of Intracellular Calcium Metabolism Subject Index.