Calcium Entry Pathways in Non-excitable Cells (Advances in Experimental Medicine and Biology Book 898)

"Calcium entry pathways in non-excitable cells presents a concise synthesis of thoughtfully selected topics covering from the different calcium entry mechanisms in non-excitable cells to the cellular microdomains and organelles regulating the calcium entry process. Particular attention is given to the fascinating group of ion channels involved in different calcium entry pathways as well as the emerging role of these channels in human disease. Calcium entry is an essential mechanism for cellular function in non-excitable cells. In general, two main calcium entry pathways exist in non-excitable cells: one pathway, named store-operated calcium entry (SOCE) requires store depletion and the second pathway is regulated by receptor occupation, but independently on calcium store depletion. The search for the molecular components of calcium entry has identified the stromal interaction molecule 1 (STIM1), as the calcium sensor of the intracellular calcium stores, and Orai as well as TRP channels as the calcium-permeable channels located in the plasma membrane. The location, interactions and function of these channels are finely regulated by a number of scaffolding proteins, membrane microdomains and cellular organelles that fine tune the amount of calcium entering the cell. Cutting-edge and user-friendly, this volume presents relevant background information, critical analysis of the current observations and directions for future research. The book is intended for basic scientists specializing in cellular biology or ion transport, as well as for biomedical researchers"--Publisher's description Front Matter....Pages i-x Front Matter....Pages 1-1 Historical Overview of Store-Operated Ca2+ Entry....Pages 3-24 The STIM1: Orai Interaction....Pages 25-46 The TRPCs, Orais and STIMs in ER/PM Junctions....Pages 47-66 TRP-Na+/Ca2+ Exchanger Coupling....Pages 67-85 Role of TRPC Channels in Store-Operated Calcium Entry....Pages 87-109 Phospholipase A2 as a Molecular Determinant of Store-Operated Calcium Entry....Pages 111-131 Extracellular Calcium Has Multiple Targets to Control Cell Proliferation....Pages 133-156 Regulation of Platelet Function by Orai, STIM and TRP....Pages 157-181 Front Matter....Pages 183-183 On the Roles of the Transient Receptor Potential Canonical 3 (TRPC3) Channel in Endothelium and Macrophages: Implications in Atherosclerosis....Pages 185-199 Second Messenger-Operated Calcium Entry Through TRPC6....Pages 201-249 Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca2+) Permeable Non-selective Cation Channel....Pages 251-264 Calcium Entry Through Thermosensory Channels....Pages 265-304 Calcium Signalling through Ligand-Gated Ion Channels such as P2X1 Receptors in the Platelet and other Non-Excitable Cells....Pages 305-329 Front Matter....Pages 331-331 The Calcium Entry-Calcium Refilling Coupling....Pages 333-352 Microdomains Associated to Lipid Rafts....Pages 353-378 Role of Scaffolding Proteins in the Regulation of TRPC-Dependent Calcium Entry....Pages 379-403 Modulation of Calcium Entry by Mitochondria....Pages 405-421 Modulation of Calcium Entry by the Endo-lysosomal System....Pages 423-447 Remodeling of Calcium Entry Pathways in Cancer....Pages 449-466 Back Matter....Pages 467-471