Calcitonin Gene-Related Peptide (CGRP) Mechanisms: Focus on Migraine (Handbook of Experimental Pharmacology, 255)

"This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention. ." - Prové de l'editor Front Matter ....Pages i-vii CGRP Discovery and Timeline (Kate Arkless, Fulye Argunhan, Susan D. Brain)....Pages 1-12 CGRP Receptor Biology: Is There More Than One Receptor? (Debbie L. Hay)....Pages 13-22 The Structure of the CGRP and Related Receptors (John Simms, Sarah Routledge, Romez Uddin, David Poyner)....Pages 23-36 CGRP Receptor Signalling Pathways (Graeme S. Cottrell)....Pages 37-64 Pathways of CGRP Release from Primary Sensory Neurons (Francesco De Logu, Romina Nassini, Lorenzo Landini, Pierangelo Geppetti)....Pages 65-84 CGRP in Animal Models of Migraine (Anne-Sophie Wattiez, Mengya Wang, Andrew F. Russo)....Pages 85-107 CGRP in Human Models of Migraine (Håkan Ashina, Henrik Winther Schytz, Messoud Ashina )....Pages 109-120 Role of CGRP in Migraine (Lars Edvinsson)....Pages 121-130 Understanding CGRP and Cardiovascular Risk (Eloísa Rubio-Beltrán, Antoinette Maassen van den Brink)....Pages 131-140 CGRP and Painful Pathologies Other than Headache (David A. Walsh, Daniel F. McWilliams)....Pages 141-167 Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies (Roxana-Maria Rujan, Christopher A. Reynolds)....Pages 169-192