Bronchial hyperresponsiveness [the Austrian Pneumological Society held its 33th Workshop on Clinical Respiratory Physiology at Graz, November 1st - 3rd, 1990

The Austrian Pneumological Society held its 33th Workshop on "Clinical Respiratory Physiology" at Graz, November 1 st -3rd, 1990. Bronchial hyperresponsiveness has been known nearly as long as asthma bronchia Ie itself. During the last two decades while exploring the inflammatory nature of asthma bronchiale we have learned a lot about measuring and modifying this phenomenon. Because of the practical relevance and owing to the high competence of the authors we hope that the lectures and discussions we had at Graz will inform and enjoy the interested reader. I want to express my deep gratitude to all the authors for providing us with the manuscripts and graphs. Finally I am especially grateful to Mrs. H. Weber for her secreterial work and to Mrs. Mag. A. Lahrmann-Ramharter for correcting the written version of the speeches and preparing a manuscript that was ready for the press. Prim. Dr. Hartmut Zwick Contents Barnes P. : Cellular and Biochemical Aspects of Airway Hyperresponsiveness. . . . . . . . . . 1 Hargreave F. E. : Airway Hyperresponsiveness and Asthma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Ingram R. H. : Physiologic Correlates of Increased Airway Responsiveness . . . . . . . . . . . . . . . . 36 K errebijn K F. : Bronchial Provocation Testing in Children -Methods and Clinical Relevance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 Tattersfield A. E. : Bronchial Provocation Testing in Adults -Is There Clinical Relevance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 Kummer F. : Principles and Approaches in Asthma Therapy. . . . . . . . . . . . . . . . . . . . . . . . . . Das cholinerge System stellt eines der Hauptregulative des bronchialen Muskeltonus dar. Es spielt bei verschiedenen obstruktiven Ventilationsstörungen eine jeweils andere - wichtige oder untergeordnete - Rolle. Es wird in diesem Buch die Brücke zwischen der Theorie (neuronale Strukturen, Rezeptoren, Mediatoren) und der klinischen Praxis geschlagen. Die Besonderheit des Buches liegt u.a. darin, daß erstmals die traditionsreiche europäische Forschung auf diesem Gebiet (W.T. Ulmer, Bochum) mit den neueren sehr klinisch orientierten Ergebnissen der Autoren aus USA (N. Gross) und Canada (Chapmann) gemeinsam präsentiert wird. Dies regt den vorgebildeten Leser zur Abwägung und zum Vergleich an, während Laien auf dem Gebiet der Atemphysiologie gleich in das Zentrum des Interesses eingeführt werden. Das Buch vermittelt einen hochmodernen Überblick über unser Verständnis des Vagus bzw. der cholinerg-mediierten Bronchokonstriktion jeweils mit konkretem klinischen Bezug auf allergisches Asthma, kindlichen Bronchospasmus, chronische Bronchitis und Emphysem. Den therapeutischen Konsequenzen wird breiter Raum gegeben. Ein spezielles Interesse wird der Interaktion von Linksherzinsuffizienz und bronchialer Hyperreaktivität (A. Lockhart, Paris) bzw. bronchialer Obstruktion gewidmet, ein wieder sehr zukunftsträchtiges Forschungsgebiet The Austrian Pneumological Society held its 33th Workshop on'Clinical Respiratory Physiology'at Graz, November 1st - 3rd, 1990. Sleep related breathing disorders have been known for many years to be an important cause of daytime disability I a huge amount of literature about this topic has been written in the last ten or fifteen years. Because of the practical relevance owing to the high competence of the authors we hope that the lectures and discussions we had at Graz will enjoy and inform the interested reader. I want to express my deep gratitude to all the authors for providing us with the manuscripts and graphs. I am especially grateful to Mrs. H. Weber for her secreterial work and to Mrs. Mag. A. Lahrmann-Ramharter for correcting the written version of the speeches and preparing a manuscript that was ready for the press. Prim. Dr. Hartmut Zwick Contents Douglas J. N.: Breathing During Sleep................... 1 Krieger J.: Pulmonary Hemodynamics in Sleep Apnea.................................16 Peter J. H.: Epidemiology of Sleep Related Breathing Disorders with Obstruction of the Upper Airways..................... The Austrian Pneumological Society held its 33th Workshop on "Clinical Respiratory Physiology" at Graz, November 1st - 3rd, 1990. Sleep related breathing disorders have been known for many years to be an important cause of daytime disability I a huge amount of literature about this topic has been written in the last ten or fifteen years. Because of the practical relevance owing to the high competence of the authors we hope that the lectures and discussions we had at Graz will enjoy and inform the interested reader. I want to express my deep gratitude to all the authors for providing us with the manuscripts and graphs. I am especially grateful to Mrs. H. Weber for her secreterial work and to Mrs. Mag. A. Lahrmann-Ramharter for correcting the written version of the speeches and preparing a manuscript that was ready for the press. Prim. Dr. Hartmut Zwick Contents Douglas J.N.: Breathing During Sleep ... 1 Krieger J.: Pulmonary Hemodynamics in Sleep Apnea ... 16 Peter J.H.: Epidemiology of Sleep Related Breathing Disorders with Obstruction of the Upper Airways .. Front Matter....Pages i-xi Cellular and Biochemical Aspects of Airway Hyperresponsiveness....Pages 1-14 Airway Hyperresponsiveness and Asthma....Pages 15-35 Physiologic Correlates of Increased Airway Responsiveness....Pages 36-45 Bronchial Provocation Testing in Children — Methods and Clinical Relevance....Pages 46-63 Bronchial Provocation Testing in Adults — Is there Clinical Relevance?....Pages 64-87 Principles and Approaches in Asthma Therapy....Pages 88-94 Das cholinerge System stellt eines der Hauptregulative des bronchialen Muskeltonus dar. Es wird in diesem Buch die Brucke zwischen der Theorie (neuronale Strukturen, Rezeptoren, Mediatoren) und der klinischen Praxis geschlagen.