Breast pathology : problematic issues

This book covers practical diagnostic issues in breast pathology, with special emphasis on areas which pose diagnostic difficulties. These include dealing with the gross specimens derived from patients treated with conservative surgery and those who had neo-adjuvant therapy before surgery. It also discusses how to deal with axillary lymph nodes, proliferative breast lesions, including DCIS, and problematic core biopsies, as well as fibro-epithelial, spindle cell, lobular, mucinous, metaplastic and papillary lesions, molecular classification of breast cancers, breast lesions in male patients and breast immunohistochemistry. There is a focus on unusual benign and malignant breast lesions and a large number of high-quality images help the reader diagnose difficult cases. __Breast Pathology: Problematic Issues__ is aimed at histopathology consultants and senior trainees who deal with breast pathology. This Book Covers Practical Diagnostic Issues In Breast Pathology, With Special Emphasis On Areas Which Pose Diagnostic Difficulties. These Include Dealing With The Gross Specimens Derived From Patients Treated With Conservative Surgery And Those Who Had Neo-adjuvant Therapy Before Surgery. It Also Discusses How To Deal With Axillary Lymph Nodes, Proliferative Breast Lesions, Including Dcis, And Problematic Core Biopsies, As Well As Fibro-epithelial, Spindle Cell, Lobular, Mucinous, Metaplastic And Papillary Lesions, Molecular Classification Of Breast Cancers, Breast Lesions In Male Patients And Breast Immunohistochemistry. There Is A Focus On Unusual Benign And Malignant Breast Lesions And A Large Number Of High-quality Images Help The Reader Diagnose Difficult Cases. Breast Pathology: Problematic Issues Is Aimed At Histopathology Consultants And Senior Trainees Who Deal With Breast Pathology. Introduction; Contents; Contributors; 1: Dealing With€the€gross Specimen; Introduction; Core Biopsies; Dealing With€specimens From€conservative Surgery; Reporting Excision Margin Status; Lumpectomy Specimens; Mastectomy Specimens; Axillary Lymph Node Specimens And€specimens Received After€neoadjuvant Therapy; References; 2: Handling Neoadjuvant Therapy Specimens; Introduction; Pretreatment Diagnosis; Specimen Handling; Wide Local Excision Specimens; Mastectomies; Axillary Lymph Nodes; Histological Reporting; Breast; Axillary Lymph Nodes; Definition Of€pcr. Grading Of€response Retesting Of€tumor Markers Post-Ưneoadjuvant Therapy; Neoadjuvant Therapy And€clinical Trials; References; 3: Proliferative Breast Lesions; Introduction; Ductal Lesions; Usual Epithelial Hyperplasia; Atypical Ductal Hyperplasia; Ductal Carcinoma In€situ; Epithelial Proliferation (hyperplasia, Atypia, And€dcis) Within€papillary Lesions; Paget's Disease Of€the€nipple; Lobular Lesions; Atypical Lobular Hyperplasia And€classical Lobular Carcinoma In€situ (in Situ Lobular Neoplasia); Columnar Cell Lesions; Columnar Cell Change And€columnar Cell Hyperplasia. Flat Epithelial Atypiareferences; 4: Problematic Core Biopsies; Introduction; Macroscopic Specimen Handling; Calcification Problems; Reporting Categories; B1, Normal Tissue; B2, Benign; B5, Malignant; Category B5a: In€situ Carcinoma; Category B5b: Invasive; Assessment Of€prognostic And€predictive Factors In€invasive Carcinoma In€core Biopsy; Problematic Malignant Lesions; B3, Lesion Of€uncertain Malignant Potential; Atypical Intraductal Epithelial Proliferations (aideps); Lobular Neoplasia; Flat Epithelial Atypia; Apocrine Lesions; Papillary Lesions. Radial Scar/complex Sclerosing Lesion (csl) Phyllodes Tumor; Spindle Cell Lesions; Mucocele-like Lesions; Other Rare Lesions; B4, Suspicious; References; 5: Ductal Carcinoma In€situ; Introduction; Specimen Handling; Diagnostic Core Biopsies; Diagnostic And€therapeutic Excision Specimens; Re-excision Specimens; Therapeutic Mammoplasties; Mastectomy Specimens; Disease Extent In€excision Specimens; Diagnostic Approaches With€core Biopsies And€excisions; Reporting Diagnostic Core Biopsies (small And€large Volume); Reporting Therapeutic Large Core (vacuum-assisted) Biopsies. Reporting Excision Biopsies Grading Dcis; Low-grade Dcis; Intermediate-grade Dcis; High-grade Dcis; Problems In€grading Dcis; Architectural Patterns And€special Types Of€dcis; Micropapillary Dcis; Apocrine Dcis; Dcis Arising In€the€context Of€a€columnar Cell Lesion With€atypia; Rare Forms Of€dcis; Dcis Following€neoadjuvant Systemic Therapy; Microinvasion And€invasion In€dcis; The Use Of€immunohistochemistry In€dcis; Differentiating Low/intermediate-Ưgrade Dcis From€benign Proliferations; Distinguishing Complex Sclerosing Processes From€invasive Disease. Sami Shousha, Editor. Includes Bibliographical References And Index. Front Matter....Pages i-xi Dealing with the Gross Specimen....Pages 1-9 Handling Neoadjuvant Therapy Specimens....Pages 11-32 Proliferative Breast Lesions....Pages 33-41 Problematic Core Biopsies....Pages 43-60 Ductal Carcinoma In Situ....Pages 61-76 Lobular Neoplasia....Pages 77-86 Grading of Invasive Carcinoma....Pages 87-95 Fibroepithelial Lesions....Pages 97-108 Mucinous Lesions of the Breast and Expression of WT1....Pages 109-121 Spindle Cell Lesions....Pages 123-136 Papillary Carcinomas....Pages 137-152 Metaplastic Breast Carcinomas....Pages 153-166 Metastatic Lesions in the Breast....Pages 167-174 Axillary Lymph Node Biopsies....Pages 175-187 A Practical Approach to the Use of Immunohistochemistry in the Diagnosis and Management of Breast Disease....Pages 189-214 Molecular Classification and Testing of Breast Carcinoma....Pages 215-231 Uncommon Benign Breast Lesions....Pages 233-245 Uncommon Malignant Lesions....Pages 247-263 Male Breast Lesions....Pages 265-274 Back Matter....Pages 275-283