Breast Cancer: Scientific and Clinical Progress : Proceedings of the Biennial Conference for the International Association of Breast Cancer Research, Miami, Florida, USA — March 1–5, 1987

Effective control of breast cancer depends on three types of research accomplishment -- understanding the disease's origins and progression: successfully applying this knowledge to methods of detection, diagnosis and treatment: and finding ways to make these advances truly available to the public as effectively as possible. The significant progress that is occurring across this entire spectrum of pioneering investigation is reflected in these proceedings of the 1987 biennial conference of the International Association for Breast Cancer Research. The first section of the book focuses on oncogenes and chemical effectors that may play key roles in early cell transformation leading to breast cancer. Research discussed includes identification of specific oncogenes which appear to be involved in the disease, study of their activation and expression, examination of the biological effects of various growth factors isolated from breast cancer cell lines, and investigation of the molecular mechanisms by which estrogens promote and stimulate growth of breast cancers. The second group of chapters deals with several other complex factors and phenomena which may influence tumor formation in the breast, for example, expression of abnormalities by fibroblasts, disruption of epithelial-mesenchymal interactions, and loss of ability nili to synthesize normal basal lamina resulting in alterations in the extracellular matrix. Clarification of the processes of normal mammary gland development and differentiation is central to much of this work. Front Matter....Pages i-xix An Analysis of Three Proto-Oncogenes in Primary Human Breast Tumor DNAs: The c-mos, the c-erbB-2 and the Epidermal Growth Factor Receptor Genes....Pages 1-10 Proviral Activation of Potential Oncogenes in Tumors Induced by Mouse Mammary Tumor Virus....Pages 11-23 Quantitative and Qualitative Changes in Oncogene Expression During Carcinogenesis....Pages 24-41 Mammary Tumor-Associated Growth Factors Origins and Possible Functions....Pages 42-54 The Oestrogen-Induced pS2 Gene and the Oestrogen Receptor in Breast Cancer....Pages 55-67 Synopsis of Workshop IV: Oncogenes and Chemical Effectors of Neoplastic Transformation....Pages 68-87 Immunological Markers in the Study of the Development of the Mouse Mammary Gland and Its Tumors....Pages 88-111 Cloning the Polymorphic Gene for the Mammary Mucin Abnormally Glycosylated in Carcinomas....Pages 112-126 Regulation of Tissue-Specific Gene Expression in the Mammary Gland: The Role of the Extracellular Matrix....Pages 127-141 The Possible Role of Abnormal Fibroblasts in the Pathogenesis of Breast Cancer....Pages 142-157 Myoepithelial and Endocrine Differentiation in Breast Carcinoma....Pages 158-173 Human Monoclonal Antibodies Directed Against Viral Antigens....Pages 174-184 Cytotoxic Effector Mechanisms Involved in the Immunity Against Mammary Tumors....Pages 185-205 Mesenchymal-Epithelial Interactions in Normal and Malignant Mammary Cells....Pages 206-212 Breast Cancer Differentiation and Progression: Analysis with Monoclonal Antibodies Flow Cytometry....Pages 213-222 Mammary Epithelial Antigens as a Breakthrough in Breast Cancer Research: Now Where to?....Pages 223-261 CA15-3 and Related Antigens as Serum Markers for Monitoring Breast Cancer....Pages 262-273 Nuclear DNA Content and Prognosis in Breast Cancer....Pages 274-284 Perspectives for the Clinical Use of Aromatase Inhibitors....Pages 285-298 Monoclonal Antibodies for Improved Evaluation of Breast Cancer Prognosis....Pages 299-320 Hormone Receptors and Interactions Workshop Summary....Pages 321-327 The Role of Diet in the Etiology and Causation of Breast Cancer....Pages 328-336 Is Primary Prevention of Breast Cancer Achievable?....Pages 337-348 Large Scale Screening Programs in Breast Cancer Prevention....Pages 349-355 Successful Research Findings: What Comes Next?....Pages 356-374 Back Matter....Pages 375-389 Proceedings of the Biennial Conference for the International Association of Breast Cancer, Miami, Florida, March 1-5, 1987