Breast Cancer Metastasis and Drug Resistance [recurso electrónico] Progress and Prospects

This volume comprehensively covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to a) fully understand the disease with all its heterogeneity, b) understand the factors that influence the metastasis of breast cancer to distant organs making it lethal and c) understand the underlying processes that lead to the phenomenon of drug-resistance making the disease particularly incurable. The book explores all of these issues, including the phenomenon of epithelial-mesenchymal-transition, cancer stem cells as well as microRNAs in an attempt to better understand the disease in connection to its heterogeneity/metastasis/drug-resistance as well as to propose novel signaling pathways for therapeutic intervention. The profiling of tumors to molecularly classify breast cancers is also investigated so that customized targeted therapies can be developed. ​ This Volume Comprehensively Covers Recent Prrogress In Breast Cancer Research. In An Effort To Successfully Treat Breast Cancer, It Is Imperative To Fully Understand The Disease With All Its Heterogeneity ; Understand The Factors That Influence The Metastasis Of Breast Cancer To Distant Organs Making It Lethal And Understand The Underlying Processes That Lead To The Phenomenon Of Drug-resistance Making The Disease Particularly Incurable. The Book Explores All Of These Issues, Including The Phenomenon Of Epithelial-mesenchymal-transition, Cancer Stem Cells As Well As Micrornas In An Attempt To Better Understand The Disease In Connection To Its Heterogeneity, Metastasis, Drug-resistance As Well As To Propose Novel Signaling Pathways For Therapeutic Intervention. The Profiling Of Tumors To Molecularly Classify Breast Cancers Is Also Investigated So That Customized Targeted Therapies Can Be Developed. Preface -- Breast Cancer Statistics -- Epidemiology Of Breast Cancer In Women -- The Complexities Of Racial Disparity In Breast Cancer -- Major Signaling Pathways Involved In Breast Cancer -- Breast Cancer Heterogeneity In Primary And Metastatic Disease -- Understanding Triple-negative Breast Cancer -- The Biology Of The Deadly Love Connection Between Obesity, Diabetes And Breast Cancer -- Progression Of Early Breast Cancer To An Invasive Phenotype -- Pre-clinical Modeling Of Breast Cancer – Which Model To Choose? -- Modeling Breast Cancer Progression In 4-d -- Bone Metastasis Of Breast Cancer -- Cellular And Molecular Mechanisms Involved In Breaching Of The Blood-brian Barrier By Circulating Breast Cancer Cells -- Resistance To Anthracyclines And Taxanes In Breast Cancer -- Understanding Of Tamoxifen Resistance Of Breast Cancer Based On Integrative Bioinformatics Approaches -- Current Understanding Of Drug Resistance Mechanisms And Therapeutic Targets In Her2 Overexpressing Breast Cancers -- Platinum And Ruthenium Complexes For The Therapy Of Breast Cancer Diseases.-development Of Notch Pathway Inhibitors For Cancer Therapy -- Systems Biology Approaches In Breast Cancer Studies -- Epigenetic Factors In Breast Cancer Progression -- Breast Cancer Stem Cells And Mirnas -- Breast Cancer Stem Cells: Responsible For Therapeutic Resistance And Relapse? -- Micrornas In Breast Cancer Research: Progress And Promise -- Index. Aamir Ahmad, Editor. Includes Bibliographical References. Front Matter....Pages i-xi Breast Cancer Statistics....Pages 1-18 Epidemiology of Breast Cancer in Women....Pages 19-34 The Complexities of Racial Disparity in Breast Cancer....Pages 35-46 Major Signaling Pathways Involved in Breast Cancer....Pages 47-64 Breast Cancer Heterogeneity in Primary and Metastatic Disease....Pages 65-95 Understanding Triple-Negative Breast Cancer....Pages 97-116 The Biology of the Deadly Love Connection Between Obesity, Diabetes, and Breast Cancer....Pages 117-142 Progression of Early Breast Cancer to an Invasive Phenotype....Pages 143-159 Pre-Clinical Modeling of Breast Cancer: Which Model to Choose?....Pages 161-175 Modeling Breast Cancer Progression in 4-D....Pages 177-188 Bone Metastasis of Breast Cancer....Pages 189-209 Cellular and Molecular Mechanisms Involved in Breaching of the Blood–Brian Barrier by Circulating Breast Cancer Cells....Pages 211-226 Resistance to Anthracyclines and Taxanes in Breast Cancer....Pages 227-247 Understanding Tamoxifen Resistance of Breast Cancer Based on Integrative Bioinformatics Approaches....Pages 249-260 Current Understanding of Drug Resistance Mechanisms and Therapeutic Targets in HER2 Overexpressing Breast Cancers....Pages 261-274 Platinum and Ruthenium Complexes for the Therapy of Breast Cancer Diseases....Pages 275-290 Development of Notch Pathway Inhibitors for Cancer Therapy....Pages 291-327 Systems Biology Approaches in Breast Cancer Studies....Pages 329-340 Epigenetic Factors in Breast Cancer Progression....Pages 341-365 Breast Cancer Stem Cells and miRNAs....Pages 367-383 Breast Cancer Stem Cells: Responsible for Therapeutic Resistance and Relapse?....Pages 385-398 MicroRNAs in Breast Cancer Research: Progress and Promise....Pages 399-413 Erratum to: Bone Metastasis of Breast Cancer....Pages E1-E1 This comprehensive book on breast cancer brings together some of the leading experts in an attempt to better understand breast cancer disease, the factors that make it lethal and current research progress, integrating both basic research with clinical implications. This volume covers the following core issues: i) heterogeneity in breast cancer - statistics, epidemiology, breast cancer subtypes, racial disparity and the associated challenges, ii) available and upcoming model systems in breast cancer research, iii) breast cancer metastasis to bones and brain, iv) drug resistance mechanisms in breast cancer against targeted therapies and v) recent developments in breast cancer research - state of current research directions / technologies / approaches. With its comprehensive coverage of topics related to breast cancer, this volume is expected to have a very wide appeal. It serves as an excellent source of reference for students/beginning researchers just setting foot in the field and interested in getting to know all the aspects of this disease. The book should also appeal to advanced and senior researchers by bringing everyone up-to-date with the most current knowledge on various breast cancer topics of utmost relevance This volume covers recent progress in breast cancer research. It explores breast cancer, the factors that make it lethal and current research progress, including stem cells, microRNAs, epigenetics, genomics and some novel signaling pathways.