Brain signal transduction and memory : proceedings of the Fifth Takeda Science Foundation Symposium on Bioscience, 1988

Brain Signal Transduction and Memory is a compilation of the proceedings of the Fifth Takeda Science Foundation Symposium on Bioscience, held on November 28-30, 1988, in Kyoto, Japan. The symposium provided a forum for the discussion of a wide range of topics on brain signal transduction and its role in memory formation. Topics covered include the role of phosphoinositides in neural signaling; the homeostasis of calcium ions; the involvement of protein kinase C in brain signal transduction and memory formation; long-term potentiation in the hippocampus; synaptic plasticity and memory; and organization of neural tissues by plasticity. This book is comprised of 21 chapters and begins with an analysis of the phosphoinositide signaling system and how it might function within the nervous system, followed by a discussion on the molecular heterogeneity of the protein kinase C family and its implications for the regulation of neuronal cells. The formation and reorganization of synaptic contacts in the developing nervous system, as well as the factors that influence the plasticity of this process, are then explored. Other chapters focus on the biochemical mechanisms involved in the generation and maintenance of enhanced synaptic transmission; quantal release in the hippocampus; molecular mechanisms of long-term depression in the cerebellum; and cellular mechanisms for reorganization of synaptic inputs after early brain damage. This monograph will appeal to biologists, physiologists, bioscientists, and clinicians. Content: Front Matter , Page iii Copyright , Page iv Foreword , Page ix , Einosuke Ohmura Preface , Page xi PHOSPHOINOSITIDES AND NEURAL SIGNALLING , Pages 3-19 , Michael J Berridge THE HETEROGENEITY OF PROTEIN KINASE C AND ITS IMPLICATIONS FOR NEURONAL CELL REGULATION , Pages 21-32 , Ushio Kikkawa, Akira Kishimoto, Kouji Ogita, Mark S. Shearman, Kazuko Sekiguchi, Katsuhiko Ase, Yasutomi Nishizuka, Yoshitaka Ono, Koichi Igarashi MOLECULAR MECHANISMS FOR LONG-TERM MEMORY IN APLYSIA , Pages 33-42 , David Sweatt, Tim Kennedy, Ari Barzilai, David Glanzman, Eric R. Kandel MECHANISMS UNDERLYING THE GENERATION AND CONTROL OF [Ca2+]i TRANSIENTS IN NEURONS AND NEUROSECRETORY CELLS. , Pages 45-60 , Sadamitsu Hashimoto, Jacopo Meldolesi, Tullio Pozzan, Cristina Fasolato HETEROGENEOUS DISTRIBUTION AND TEMPORAL CHANGES OF CYTOPLASMIC FREE CALCIUM IN GASTRIC PARIETAL CELLS AND PLATELETS , Pages 61-71 , Yutaka Tashiro, Susumu Yodozawa, Yasuhiro Tsunoda, Kazuhiko Matsuno THE ROLE OF Ca 2+ /CALMODULIN-DEPENDENT PROTEIN KINASE II IN NEURONAL FUNCTIONS , Pages 73-85 , E. Miyamoto, K. Fukunaga, Y. Ohta, H. Yamamoto, S. Yasugawa, S. Goto, T. Ohba CYTOCHEMICAL EVIDENCE OF PROTEIN KINASE C IN NEURONAL TISSUES , Pages 89-100 , Chikako Tanaka, Naoaki Saito, Akiko Kose, Kohkichi Hosoda, Atsuko Ito, Takeshi Tsujino, Miyako Mori, Midori Hirata THE PROTEIN KINASE C SUBSTRATE PROTEIN B-50 IN NEURAL SIGNAL TRANSDUCTION AND PLASTICITY , Pages 101-116 , W.H. Gispen, P.N.E. De Graan, A.B. Oestreicher, P. Schotman, L.H. Schrama Modulation of Two K + Currents by Inositol Trisphosphate and Protein Kinase C , Pages 117-128 , Haruhiro Higashida, David. A. Brown, Akihiko Ogura, Junji Sagara, Kazuhiro Nagata THE ROLE OF PROTEIN KINASE C AND PHOSPHOINOSITIDE METABOLITES IN NEURONS THAT CONTROL PROLONGED REPRODUCTIVE BEHAVIORS IN APLYSIA , Pages 129-141 , L.K. Kaczmarek QUANTAL RELEASE IN THE HIPPOCAMPUS , Pages 145-158 , Chosaburo Yamamoto, Satsuki Sawada, Haruyuki Kamiya MECHANISMS INVOLVED IN THE INITIATION AND EXPRESSION OF LONG TERM POTENTIATION , Pages 159-170 , Roger A. Nicoll, Robert C. Malenka, Julie A. Kauer Cholinergic and Noradrenergic Modulation of Long-term Potentiation in Hippocampal CA3 Neurons , Pages 171-183 , Daniel Johnston, Stephen H. Williams, Richard Gray, Ronald E. Fisher PRESYNAPTIC MECHANISMS UNDERLYING THE MAINTENANCE OF LONG-TERM POTENTIATION IN THE HIPPOCAMPUS , Pages 185-196 , T.V.P. Bliss, M.P. Clements, M.L. Errington, M.A. Lynch, J.H. Williams MOLECULAR MECHANISMS OF LONG-TERM DEPRESSION IN THE CEREBELLUM , Pages 199-212 , Masao Ito MOLECULAR BASIS FOR THE HEBB SYNAPSE , Pages 213-227 , Aryeh Routtenberg THE PHYSICAL REALITY OF MEMORY , Pages 229-240 , Daniel L. Alkon, James Olds, Thomas Nelson MOLECULAR MECHANISMS UNDERLYING SYNAPTIC PLASTICITY IN THE DEVELOPING VISUAL CORTEX , Pages 241-255 , Tadaharu Tsumoto, Fumitaka Kimura, Kouichiro Hagihara, Ayahiko Nishigori, Kenji Sobue TERMINAL SPROUTING AND FUNCTIONAL PLASTICITY AT NEUROMUSCULAR JUNCTIONS , Pages 259-268 , Motoy Kuno, Tetsuhiro Tsujimoto ROLES OF NERVE GROWTH FACTOR IN THE CENTRAL NERVOUS SYSTEM , Pages 269-280 , Hiroshi Hatanaka CELLULAR MECHANISMS FOR REORGANIZATION OF SYNAPTIC INPUTS AFTER EARLY BRAIN DAMAGE , Pages 281-292 , Fujio Murakami Index , Pages 293-297