Brain Repair (Advances in Experimental Medicine and Biology Book 557)

Brain Repair, addresses all relevant issues underlying the mechanisms of brain damage, brain plasticity and post-traumatic reorganisation after CNS lesions. This book is divided the three major sections that follow; cellular and molecular basis of brain repair, plasticity and reorganisation of neural networks, and experimental therapy strategies. Brain Repair is written by high profile, international experts who describe in detail the newest results from basic research and highlight new model systems, techniques and therapy approaches. Based on a careful analysis of the cellular and molecular reaction patterns of the CNS to lesions, the contributions cover possibilities for endogenous reorganisation and repair as well as exciting new therapies emerging from basic research, some of which have already been introduced into the clinics. Thus, this book is unique in bridging the gap between basic and clinical research. It will be a valuable tool for all students, researchers and clinicians interested in understanding the brain's capacity to cope with lesions and interested in learning about emerging new therapy concepts. Cell death in the nervous system / Kerstin Krieglstein -- The glial response to injury and its role in the inhibition of CNS repair / James W. Fawcett -- DSD-1-proteoglycan/phosphacan and receptor protein tyrosine phosphatase-beta isoforms during development and regeneration of neural tissues / Andreas Faissner ... [et al.] -- Regeneration failure in the CNS / Anne D. Zurn and Christine E. Bandtlow -- The role of ionotropic purinergic receptors (P2X) in mediating plasticity responses in the central nervous system / Fulvio Florenzano ... [et al.] -- Lesion-induced axonal sprouting in the central nervous system / Thomas Deller ... [et al.] -- A kinase with a vision / Gian Michele Ratto and Tommaso Pizzorusso -- Attempts to restore visual function after optic nerve damage in adult mammals / Tomomitsu Miyoshi, Takuji Kurimoto and Yutaka Fukuda -- Brain repair / Mathia Bähr and Paul Lingor -- Neuroprotection by camp / Mariana S. Silveira and Rafael Linden -- The collagenous wound healing scar in the injured central nervous system inhibits axonal regeneration / Susanne Hermanns ... [et al.] -- Role of endogenous neural stem cells in neurological disease and brain repair / Jörg Dietrich and Gerd Kempermann -- Transplantation in Parkinson's disease / Gesine Paul ... [et al.] Annotation Brain Repair, addresses all relevant issues underlying the mechanisms of brain damage, brain plasticity and post-traumatic reorganisation after CNS lesions. This book is divided the three major sections that follow; cellular and molecular basis of brain repair, plasticity and reorganisation of neural networks, and experimental therapy strategies. Brain Repair is written by high profile, international experts who describe in detail the newest results from basic research and highlight new model systems, techniques and therapy approaches. Based on a careful analysis of the cellular and molecular reaction patterns of the CNS to lesions, the contributions cover possibilities for endogenous reorganisation and repair as well as exciting new therapies emerging from basic research, some of which have already been introduced into the clinics. Thus, this book is unique in bridging the gap between basic and clinical research. It will be a valuable tool for all students, researchers and clinicians interested in understanding the brain's capacity to cope with lesions and interested in learning about emerging new therapy concepts Cell Death in the Nervous System....Pages 1-10 The Glial Response to Injury and Its Role in the Inhibition of CNS Repair....Pages 11-24 DSD-1-Proteoglycan/Phosphacan and Receptor Protein Tyrosine Phosphatase-Beta Isoforms during Development and Regeneration of Neural Tissues....Pages 25-53 Regeneration Failure in the CNS....Pages 54-76 The Role of Ionotropic Purinergic Receptors (P2X) in Mediating Plasticity Responses in the Central Nervous System....Pages 77-100 Lesion-Induced Axonal Sprouting in the Central Nervous System....Pages 101-121 A Kinase with a Vision....Pages 122-132 Attempts to Restore Visual Function after Optic Nerve Damage in Adult Mammals....Pages 133-147 Brain Repair....Pages 148-163 Neuroprotection by cAMP....Pages 164-176 The Collagenous Wound Healing Scar in the Injured Central Nervous System Inhibits Axonal Regeneration....Pages 177-190 Role of Endogenous Neural Stem Cells in Neurological Disease and Brain Repair....Pages 191-220 Transplantation in Parkinson’s Disease....Pages 221-248 Addresses all relevant issues underlying the mechanisms of brain damage, brain plasticity, and post-traumatic reorganization after CNS lesions