Brain Oncology Biology, Diagnosis and Therapy : An International Meeting on Brain Oncology, Rennes, France, September 4–5, 1986, Held Under the Auspices of the Ministry of National Education, the University of Rennes and the Regional Hospital Rennes

The International Meeting on Brain Oncology in Rennes was organised in honor of Jean Pecker, to pay tribute to his contribution to the development of neurological sciences and to take stock of the current state of knowledge on brain tumors, a domain in which the role of neurosurgery has been and will continue to be primordial. During the two-day conference, the major themes of brain oncology studies, both fundamental and clinical, were examined: oncogenesis, tumoral markers and immunology, metabolic and diagnosis imaging, prognostic factors and therapeutic strategies. The large number and high quality of participations resulted in a genuinely synthetic view of current advances in research, of which this book presents the essentials. We have attempted both to preserve the richness of scientific exchanges which occurred and to publish a great many oral and poster communications. The book respects the organization of conference sessions, and thus reflects the importance accorded to glial tumor studies. This may seem disproportionate given their frequency of occurrence in proportion to total numbers of intracranial tumor processes, but their gravity and quasi-total resistance to current therapeutic methods are ample justification. Moreover, this is the domain in which hopes of progress are beginning to appear, and it is becoming possible to envisage treatment based on recently established fundamental knowledge. Front Matter....Pages I-XIX Front Matter....Pages 1-1 Genetics Of Neuroepithelial Brain Tumours....Pages 3-6 Oncogenes, Growth Factors and the Pathogenesis of Human Glioma: The 1986 Engelhardt Lecture....Pages 7-13 Amplification and Expression of Viral Sequences and Oncogenes in Human Brain Tumors....Pages 15-19 Chromosomal Studies in Malignant Gliomas....Pages 21-23 Karyotype Patterns in Forty Human Meningiomas....Pages 25-28 Front Matter....Pages 29-29 Immunohistochemistry in Neuro-Oncology: Markers or Signposts?....Pages 31-34 Immunocytochemistry and the Pathological Diagnosis of Cerebral Tumours....Pages 35-39 GFAP Immunoreactivity of Oligoastrocytomas Study of 120 Cases....Pages 41-45 GFA and S 100 Proteins in Low Grade Astrocytomas....Pages 47-53 Intermediate Filaments in Fresh Frozen Tissue in Neuro-Oncology — About a Series of 1000 Peroperative Biopsies —....Pages 55-60 Glutamine Synthetase, a Marker of an Astroglial Subpopulation in Mouse Brain....Pages 61-65 Correlation of in situ cell Kinetics and Degree of Anaplasia in Human Brain Tumors: Identification of S-phase cells with anti-BUdR Antibodies....Pages 67-74 Prognostic Value of Labeling Index in Stereotactic Biopsies of Glial Tumours....Pages 75-78 Proliferative Potential of Malignant and Non-Malignant Meningiomas....Pages 79-81 Histological Patterns in Germ Cell Tumors....Pages 83-85 Dysontogenetic Brain Tumours. Morphological Variability and Problems of Classification....Pages 87-90 Congenital intracranial tumors....Pages 91-99 Meningiomas: the Value of Diagnostic Cytology by Tissue Imprints....Pages 101-103 Front Matter....Pages 105-105 Modulation of Class I and Class II Major Histocompatibility Complex Antigens in Gliomas....Pages 107-113 Isolation, Functional Properties and Clonal Analysis of Tumor-Infiltrating Lymphocytes from Human Brain Tumors....Pages 115-119 Front Matter....Pages 105-105 The Applications of Monoclonal Antibodies in Neuro-Oncology....Pages 121-124 In-vivo-localization of Radiolabelled Monoclonal Antibody in Human Gliomas....Pages 125-128 Levels of Polyamine Biosynthetic Decarboxylase Activities as Indicators of the Degree of Malignancy of Human Primary Central Nervous System Tumors....Pages 129-133 Red Blood cell Polyamines in the Long Term Follow-up of Malignant Gliomas....Pages 135-142 The Selective Release of Polypeptides from Human Glioma Cell Cultures and their Modification by Dexamethasone....Pages 143-148 Preliminary Assessment of the Correlation between Clinicopathological Features of Intracranial Tumours and the Amount of Extractable Angiogenic Activity: High and Low M r factors....Pages 149-152 Estrogen and Progesterone Receptors in Central Nervous System Tumors....Pages 153-157 Steroid Hormone Receptors and Intracranial Tumors....Pages 159-163 Steroid Sex Hormones in Non-Pituitary Brain Tumours....Pages 165-167 Trials of Hormonal Manipulation of Meningiomas in vivo and in vitro....Pages 169-171 Front Matter....Pages 173-173 Metabolic Studies of Brain Tumours by PET....Pages 175-177 Study of 11 C-L-Methionine Uptake in Brain Gliomas by Positron Emission Tomography: Metabolic Grading, and Effects of Radiotherapy and Intra-Arterial Chemotherapy....Pages 179-183 Positron Emission Tomography with 11-C-Methionine of Intracranial Tumours compared with Histology of Multiple Biopsies....Pages 185-186 Neuropathology and Regional Imaging of Microcirculation, Tissue pH, Metabolites and Necroses in Cerebral RG2 and F98 Anaplastic Rat Glioma Transplantation Tumors....Pages 187-199 Can Polyamines act as Positron Emitters in Cerebral Oncology? Preliminary results obtained in nude mice bearing human glioblastoma xenografts....Pages 201-204 Conception and Evaluation of a MRI and CT Stereotactic Frame in Neuro-Oncology....Pages 205-210 MRI and the Surgical Treatment of Low Grade Gliomas....Pages 211-215 Brain Electrical Activity Mapping in Brain Tumors....Pages 217-221 An Expert System for the Diagnosis of Brain Tumours in Computer Tomographic Images and Histopathologically....Pages 223-226 Front Matter....Pages 227-227 Multi-Centre Epidemiological Study on Primary Cerebral Tumours in the Veneto Region Preliminary data from June 1st 1985 to December 31 st 1985....Pages 229-231 Front Matter....Pages 227-227 Chemically Induced Human Gliomas Occurrence of Brain Gliomas in three Matchbox Manufacturers An occupational risk ?....Pages 233-235 Prospective Analysis of Grade III and IV Gliomas, With Considerations on Histological Classification. (An E.O.R.T.C. Brain Tumor Group Study)....Pages 237-242 Histological Factors in the Prognosis of Malignant Gliomas....Pages 243-247 Supra-Tentorial Gliomas: Multivariate Analysis of Prognostic Factors....Pages 249-252 High Graded Astrocytoma: Results of Treatment....Pages 253-256 Primary Malignant non Hodgkin’s Lymphomas of the Central Nervous System Report of two cases with a Predominant Callosal Localization....Pages 257-266 Tumours of the Pineal Region....Pages 267-270 Meningeal and Intra-cerebral Localizations of Kaposi’s Sarcoma in AIDS....Pages 271-273 Intracranial Meningiomas with Extracranial Dissemination....Pages 275-282 Intracranial Soft Meningiomas: Diagnostic and Therapeutic Study about 33 Cases....Pages 283-285 Brain Metastases Revealing Lung Cancer. The Effect of Combined Surgery on Quality and Duration of Survival....Pages 287-291 Front Matter....Pages 293-293 Therapeutic Modalities in Low-Grade Brain Gliomas....Pages 295-299 Evaluation of Stereotactic Biopsy as an aid to the Management of Supratentorial Tumors:....Pages 301-304 Intraoperative Ultrasonography in Neurosurgery....Pages 305-307 Surgery as Definitive Salvage Therapy for Primary Brain Tumors....Pages 309-313 Radiation Therapy in the Treatment of Malignant Supratentorial Gliomas: Current Trends and Prospects. A Review....Pages 315-318 Whole Brain Irradiation is not necessary for the Treatment of Malignant Supra-Tentorial Gliomas....Pages 319-322 Quality of Treatment Response and Survival in Patients with Supra-Tentorial Malignant Gliomas....Pages 323-328 Neuropsychologic Impairment in Adults with Brain Tumors after Radiation Therapy....Pages 329-334 The Tolerance of Irradiation in Children with Brain Tumour....Pages 335-338 Front Matter....Pages 293-293 Human High-Grade Gliomas Grafted into Nude Mice: A Model System to Compare Radiotherapy Schedules....Pages 339-343 Pharmacology of the Hypoxic cell Radiosensitizers Ro 03-8799 and SR 2508 in Human Gliomas and Brain Tissue....Pages 345-347 Antibody-Guided Irradiation Therapy for Cases of Neoplastic Meningitis....Pages 349-352 Front Matter....Pages 353-354 An In Vitro Comparative Study of BCNU, VM 26, 5-FU and Ara-A5’P in Treatment of Primary and Secondary CNS-Neoplasms; Potential Clinical Relevance and Clinical Correlations....Pages 355-361 Heterogeneity in Chemosensitivity and Acquisition of Drug Resistance in a Murine Model of Glioma....Pages 363-367 Assay of Anticancer Drugs in Tissue Culture: The Effect of Cell Kinetics and the Mode of Action of Drugs on the Chemosensitivity of Cultures Derived from Malignant Brain Tumours....Pages 369-371 Chemosensitivity Studies on Human Gliomas in Nude Mice Preliminary Results....Pages 373-376 Rat Glioma Follow-Up by In-Vivo 31-Phosphorus Magnetic Resonance Spectroscopy: Activity of Two New Antineoplastic Agents....Pages 377-380 31-P-NMR Spectroscopy in vivo of Human and Rat Brain Tumors Grafted on Nude Mice....Pages 381-384 Blood Brain Barrier Modification and Chemotherapy in Treatment of Malignant Gliomas....Pages 385-386 Human Central Nervous System Pharmacology of Antineoplastic Agents: Implications for the Treatment of Brain Tumors....Pages 387-395 Intraarterial Chemotherapy for Brain Tumors: A Summary of the Ottawa Experience....Pages 397-402 Intra-Arterial Chemotherapy Using Extra-Intracranial by-Pass for the Treatment of Malignant Gliomas....Pages 403-407 Intra-Arterial Chemotherapy With BCNU. Correlations between Tumour Growth and Red Blood Cell Polyamine Levels....Pages 409-412 Effects of Intra-Arterially Administered 1,3-bis[2-chloroethyl]-1-nitrosurea (BCNU) on the Electroretinogram of the Rabbit A Study on the Retinal Toxicity of BCNU....Pages 413-417 Cerebral Toxicity Following Supraophthalmic Intracarotid Infusion of BCNU: Study of 4 Malignant Gliomas....Pages 419-421 Preliminary Experience With Menogaril in the Treatment of Recurrent Glioblastomas....Pages 423-426 Chemotherapy in the Management of Pineal Region Germinomas....Pages 427-428 The Effectiveness of Chemotherapy in a Case of Childhood Esthesioneuroblastoma....Pages 429-431 Renaissance of Intratumoural Chemotherapy....Pages 433-434 Front Matter....Pages 353-354 Chemotherapy of Malignant Supratentorial Gliomas: Achievements and Prospectives....Pages 435-438 Early Phase II Study of the Adoptive Immunotherapy of Human Brain Tumors with Lymphokine-Activated Killer (LAK) Cells and Recombinant Interleukin-2 (rIL-2)....Pages 439-443 Immunotherapy in Recurrent Malignant Brain Tumors....Pages 445-448 Back Matter....Pages 449-459