Brain Hypothermia : Pathology, Pharmacology, and Treatment of Severe Brain Injury

Rapid progress in technology and its application to diagnosis and monitoring of brain tissue temperature and metabolism have resulted in advances in the therapy for critically brain-injured patients and breakthroughs in understanding the pathophysiology of brain damage. The latest concept of brain hypothermia therapy clarifies targets such as brain thermal pooling, masking brain hypoxia associated with catecholamine surge, the metabolic shift from glucose to lipids, and selective radical damage of dopamine in the central nervous system. This volume explains the mechanism of brain injury and how brain hypothermia treatment differs from other hypothermia therapy in four major sections: Brain Injury Mechanism, Pathophysiology of Hypothermia, Basic Research of Hypothermia Treatment, and Clinical Studies of Brain Hypothermia. The book is a valuable source for practitioners and researchers in neurosurgery and neurology and in critical care and emergency medicine. Front Matter....Pages II-IX Front Matter....Pages 1-1 Enhanced Neuronal Damage in Severely Brain-Injured Patients by Hypothalamus, Pituitary, and Adrenal Axis Neurohormonal Changes....Pages 3-25 Front Matter....Pages 27-27 Molecular System Controlling Mammalian Hibernation with Circannual Rhythm....Pages 29-36 Front Matter....Pages 37-37 Therapeutic Hypothermia in Experimental Models of Traumatic Brain Injury....Pages 39-46 Mild Hypothermia Amelioration of Damage During Rat Spinal Cord Injury: Inhibition of Pathological Microglial Proliferation and Improvement of Hind-limb Motor Function....Pages 47-54 Local Cooling: Limits on Secondary Injury and Neuronal Death Following Spinal Cord Injury....Pages 55-59 Effect of Intraischemic Hypothermia on Expression of c-Fos, c-Jun, and HSP72 After Transient Focal Cerebral Ischemia in Rat Brain....Pages 61-67 Neuroprotective Effect of Mild Hypothermia in Experimental Brain Ischemia....Pages 69-82 Front Matter....Pages 83-83 Spontaneous Cerebral Hypothermia After Severe Head Injury: Relation with Brain Chemistry and Cerebrovascular Parameters....Pages 85-97 Effect of Therapeutic Moderate Hypothermia on Extracellular and CSF Intermediates of Secondary Brain Injury....Pages 99-102 Significance of Electrophysiologic Studies in Brain Hypothermia....Pages 103-108 Mapping Analysis of Brain Tissue Temperature by Magnetic Resonance Imaging....Pages 109-112 Bacteria Detected and the Pharmacokinetics of Antibiotics During Brain Hypothermia....Pages 113-119 The Clinical Issue and Effectiveness of Brain Hypothermia Treatment for Severely Brain-Injured Patients....Pages 121-151 Development and Status of Hypothermia for Brain Injury: National Acute Brain Injury Study: Hypothermia....Pages 153-160 Intravascular Volume Expansion During Therapeutic Moderate Hypothermia for Brain-Injured Patients: Preliminary Report....Pages 161-168 Treatment of Hyperacute Embolic Stroke with Major Cerebral Artery Occlusion by Mild Hypothermia....Pages 169-174 Mild Hypothermia Therapy for Severe Acute Brain Insults in Clinical Practice....Pages 175-185 Combined Therapy of Local Intraarterial Thrombolysis and Brain Hypothermia for Acute Occlusion of the Cerebral Main Trunk Arteries....Pages 187-193 Mild Hypothermia for Cerebral Resuscitation in Survivors of Out-of-Hospital Ventricular Fibrillation....Pages 195-202 New Hypothermia Method Using Blood Cooling System: MONAN and KANEM Method....Pages 203-209 Front Matter....Pages 211-211 Panel Discussion....Pages 213-217 Front Matter....Pages 219-219 Summary....Pages 221-226 Back Matter....Pages 227-231