Brain Extracellular Matrix in Health and Disease (ISSN Book 214)

In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells. * Authors are the leading experts in the field of brain extracellular matrix in health and disease * Book covers the most important aspects of brain extracellular matrix in health and disease * Interesting for both scientists and clinicians Content: Brain extracellular matrix meets COST : matrix for European research networks / Srecko Gajovic, Roland Pochet -- Pt. 1. Functions of neural ECM. Ch. 1. Regulation of the neural stem cell compartment by extracellular matrix constituents / Ursula Theocharidis, Katherine Long, Charles ffrench-Constant, Andreas Faissner -- Ch. 2. Neural ECM and synaptogenesis / Anne Heikkinen, Taina Pihlajaniemi, Andreas Faissner, Michisuke Yuzaki -- Ch. 3. Neural ECM molecules in synaptic plasticity, learning, and memory / Oleg Senkov, Pavle Andjus, Lidija Radenovic, Eduardo Soriano, Alexander Dityatev -- Ch. 4. Neural ECM molecules in axonal and synaptic homeostatic plasticity / Renato Frischknecht, Kae-Jiun Chang, Matthew N. Rasband, Constanze I. Seidenbecher -- Ch. 5. ECM receptors in neuronal structure, synaptic plasticity, and behavior / Meghan E. Kerrisk, Lorenzo A. Cingolani, Anthony J. Koleske -- Pt. 2. Neural ECM in brain diseases. Ch. 6. neural ECM proteases in learning and synaptic plasticity / Effie Tsilibary, Athina Tzinia, Lidija Radenovic, Vera Stamenkovic, Tomasz Lebitko, Mariusz Mucha, Robert Pawlak, Renato Frischknecht, Leszek Kaczmarek -- Ch. 7. Neural ECM in laminar organization and connectivity development in healthy and diseased human brain / Natasa Jovanov Milosevic, Milos Judas, Eleonora Aronica, Ivica Kostovic -- Ch. 8. Neural ECM in regeneration and rehabilitation / Jessica C. F. Kwok, Sujeong Yang, James W. Fawcett -- Ch. 9. On the structure and functions of gelatinase B/matrix metalloproteinase-9 in neuroinflammation / Jennifer Vandooren, Jo Van Damme, Ghislain opdenakker -- Ch. 10. ECM in brain aging and dementia / Markus Morawski, Mikhail Filippov, Athina Tzinia, Effie Tsilibary, Lydia Vargova -- Ch. 11. Neural ECM epilepsy / Asla Pitkänen, Xavier E. Ndode-Ekane, Katarzyna Lukasiuk, Grzegorz M. Wilczynski, Alexander Dityatev, Matthew C. Walker, Elodie Chabrol, Stefanie Dedeurwaerdere, Naiara Vazquez, Elizabeth M. Powell -- Ch. 12. Neural ECM in addiction, schizophrenia, and mood disorder / Bart R. Lubbers, August B. Smit, Sabine Spijker, Michel C. van den Oever -- Pt. 3. Neural ECM-targeting tools and therapeutics. Ch. 13. Current microscopic methods for the neural ECM analysis / Andre Zeug, Michal Stawarski, Katarzyna Bieganska, Svetlana Korotchenko, Jakub Wlodarczyk, Alexander Dityatev, Evgeni Ponimaskin -- Ch. 14. Endogenous and synthetic MMP inhibitors in CNS physiopathology / Kévin Baranger, Santiago Rivera, Fabian D. Liechti, Denis Grandgirard, Judit Bigas, Jesús Seco, Teresa Tarrago, Stephen L. Leib, Michel Khrestchatisky -- Ch. 15. Targeting of ECM molecules and their metabolizing enzymes and receptors for the treatment of CNS diseases / Vladimir Berezin, Peter S. Walmod, Mikhail Filippov, Alexander Dityatev -- Pt. 4. Neural ECM scaffolds. Ch. 16. Neural ECM mimetics / Veronica Estrada, Ayse Tekinay, Hans Werner Müller -- Ch. 17. Integration of microstructured scaffolds, neurons, and multielectrode arrays / Alessandro Simi, Hayder Amin, Alessandro Maccione, Thierry Nieus, Luca Berdondini -- Ch. 18. Intracellular signaling and perception of neuronal scaffold through integrins and their adapter proteins / Bernhard Wehrle-Haller, Martin Bastmeyer.

In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells.

• Authors are the leading experts in the field of brain extracellular matrix in health and disease
• Book covers the most important aspects of brain extracellular matrix in health and disease
• Interesting for both scientists and clinicians