Brain Dopaminergic Systems: Imaging with Positron Tomography : Proceedings of a Workshop held in Caen, France within the framework of the European Community Medical and Public Health Research

**'**....the book is most valuable for those who are starting to study the brain dopaminergic system and are considering PET as a tool.**'****Nuclear Medicine** 19:9 1992 Imaging of the Dopaminergic system in the human brain with the in vivo use of Positron Emis sion Tomography has emerged in the late 1980s as a tool of major importance in Clinical Neuros ciences and Pharmacology. The last few years have witnessed the rapid development of new radiotracers specific to receptors, reuptake sites and enzymes of the dopamine system; the application of these radiotracers has led to major breakthroughs in the pathophysiology and therapy of movement disorders and schizophrenic-like psychoses. This book is the first to collect, in a single volume, state-of-the-art contributions to the various aspects of this research. Its contents address methodological issues related to the design, labelling, quantitative imaging and compartmental modelisation of radioligands of the post-synaptic, pre-synaptic and enzyme sites of the dopamine system and to their use in clinical research in the fields of Parkinson's disease as well as other movement disorders, psychoses and neuroleptic receptor occupancy. The chapters were written by leading European scientists in the field of Positron Emission Tomography, gathered together in Caen (France, November 1990) under the aegis of the EEC Concerted Action on "PET Investigations of Cellular Regeneration and Degeneration. This book provides a current and comprehensive overview on PET studies of the brain dopamine system which should aid and interest neurologists, psychiatrists, pharmacologists and medical imaging scientists. J.C. Baron D. Comar L. Farde J.L. Martinot B. Mazoyer August 1991 ix LIST OF CONTRffiUTORS Dr Yves Agid DrL Front Matter....Pages i-xii Neuroanatomy of Dopaminergic System in the Human Brain....Pages 1-4 Radioligands for PET Studies of D 2 -Receptors: Butyrophenone and Ergot Derivatives....Pages 5-22 Radioligands for Dopamine Receptor PET Studies: Benzamides and Ligands for Dopamine D-1 Receptors....Pages 23-38 Monoamine Precursors in PET Research- Biochemical Issues and Functional Significance....Pages 39-52 Quantitation Problems in Positron Emission Tomography (PET) as Applied to the Kinetic Analysis of the Striatum Dopamine Data....Pages 53-64 Investigation of the Dopamine System with Positron Emission Tomography: General Issues in Modelling....Pages 65-83 Modelisation: Application to the D 2 Receptors....Pages 85-95 [18F]Fluorodopa Uptake in Brain....Pages 97-110 Dopamine Reuptake Sites: The Issues....Pages 111-119 Movement Disorders: the clinical issues....Pages 121-134 Non-Human Primate Models of Dopamine System Disorders: Understanding Neurodegenerative Diseases and Testing New Therapeutic Strategies....Pages 135-146 The Dopamine System and Mental Disorders: Clinical and Psychopharmacological Overview....Pages 147-167 D2 Dopamine Receptors and Schizophrenia....Pages 169-180 The Assessment of Central D 2 -Dopamine Receptor Occupancy with Positron Emission Tomography in Long-Term Medicated Schizophrenic Patients....Pages 181-189 Measurement of Dopamine Receptor Occupancy: Clinical Issues....Pages 191-198 Back Matter....Pages 199-200 ' ....the book is most valuable for those who are starting to study the brain dopaminergic system and are considering PET as a tool. ' Nuclear Medicine 19:9 1992