Brain Disease : Therapeutic Strategies and Repair

In this volume, leading scientists review new findings on how the central nervous system (CNS) responds to injury. Brain Disease addresses the mechanisms of CNS disorders, such as multiple sclerosis, Alzheimer's disease, stroke and traumatic brain injury. Attention is focused on the role of genetic and environmental factors, pathophysiology of immune-mediated brain injury, blood-brain barrier eruption and brain edema, apoptotic mechanisms and the matrix metalloproteinases. Other topics include repair mechanisms, gene therapy and the use of stem cells for CNS remyelination. The text is essential for practicing neurologists, neurosurgeons, geriatricians and students in those fields. Book Cover......Page 1 Title......Page 4 Contents......Page 5 Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .......Page 7 Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .......Page 8 The spectrum of neuroimmunologic diseases......Page 14 Heterogeneity in multiple sclerosis......Page 24 Microglia and brain macrophages......Page 34 Humoral immune response and antibody-mediated brain injury......Page 42 Antibody-mediated remyelination......Page 50 Apoptosis in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)......Page 58 Cell migration and adhesion molecules at the blood brain barrier in experimental autoimmune encephalomyelitis and multiple sclerosis......Page 64 Matrix metalloproteinases and their inhibitors in brain injury and repair......Page 76 Monitoring progression of multiple sclerosis: p-cresol sulfate is the dominant component of urine myelin basic protein-like material......Page 82 Immunomodulation and therapy in multiple sclerosis......Page 86 Immunogene therapy for autoimmune demyelination......Page 96 DNA vaccination for central nervous system autoimmune diseases......Page 104 Stem cell transplantation for neurological diseases: new hope for disorders of myelin?......Page 110 Viruses in neurological disease......Page 120 Chronic fatigue syndrome and systemic viral infections: current evidence and recent advances......Page 140 Bacterial meningitis......Page 150 Human prion diseases......Page 156 Neurologic manifestations of lymphoproliferative disorders......Page 164 Cerebrovascular disorders: therapeutic strategies and repair......Page 176 Vasculitis of the nervous system......Page 186 Brain vasculitis and antiphospholipid syndrome......Page 206 Neuronal protection in cerebral ischemia;from lessons of the past to a brighter future......Page 214 Immunomodulation;new therapeutic opportunities for stroke......Page 224 Toxicity of tumor necrosis factor is enhanced by reactive oxygen species after brain trauma......Page 232 Protective autoimmunity: is vaccination for neurodegenerative disorders feasible?......Page 238 The molecular biology of blood brain barrier disruption under stress: the potential involvement of acetylcholinesterase......Page 244 Clinically important interactions involving new antiepileptic drugs......Page 252 Challenges in monitoring the new antiepileptic drugs......Page 258 Aggravation of seizures by antiepileptic drugs: pathophysiology and clinical implications......Page 264 Management of paroxysmal symptoms in multiple sclerosis......Page 270 An update on therapy for Parkinson's disease......Page 280 Restoring structure and function of the nigrostriatal system in Parkinson's disease......Page 288 Therapeutic of hyperkinetic movement disorders......Page 296 Molecular events in dopaminergic neurodegeneration and neuroprotection in MPTP model of Parkinson's disease employing cDNA microarray......Page 304 Alzheimer's disease......Page 312 Vasculitic neuropathies......Page 326 Acquired demyelinating neuropathies: molecular mechanisms and novel therapeutical approaches......Page 338 Radiation damage to peripheral nerves......Page 350 Neuropathy due to malignant hematological diseases......Page 360 Hereditary inclusion body myopathies: clinical and genetic features......Page 364 Exercise testing in muscle disease......Page 370 Disorders of emotional behaviour......Page 382 Cognitive and affective disturbances in multiple sclerosis......Page 388 From spinal shock to spasticity......Page 392 Pathophysiology and treatment of fatigue in multiple sclerosis......Page 402 Management of vertigo and vestibular disorders......Page 408 Eye movements: supranuclear mechanisms and their disorders......Page 418 The role of radionucleid brain scan and multimodality......Page 432 Imaging brain inflammation......Page 438 Advances in neurosonology......Page 448 Neurophysiology of inflammatory demyelinating disease......Page 460 Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .......Page 476 Recent research has unearthed new insights into brain disease. In this volume, leading scientists review the latest experimental and clinical findings on how the central nervous system (CNS) responds to injury. Brain Disease encompasses the mechanisms of CNS disorders, such as multiple sclerosis, Alzheimer's disease, stroke and traumatic brain injury. Attention is focused on the role of genetic and environmental factors, pathophysiology of immune-mediated brain injury, blood-brain barrier eruption and brain edema, apoptotic mechanisms, cytokines, chemokines and the matrix metalloproteinases (MMPs). Other topics include repair mechanisms, gene therapy and the use of stem cells for CNS remyelination, regeneration, neurogenesis and compensatory plasticity. Brain Disease is indispensable for practicing neurologists, neurosurgeons, geriatricians and students in those fields Scientists review experimental and clinical findings on the diverse mechanisms with which the central nervous system responds to injury and explores therapeutic interventions aimed at promoting functional recovery. Presenting new insights and concepts gained through recent research in brain disease, this reviews the latest experimental and clinical findings on which the central nervous system (CNS) responds to injury