Bone Metastases: A translational and Clinical Approach (Cancer Metastasis - Biology and Treatment Book 21)

The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease. Front Matter....Pages i-ix Front Matter....Pages 1-1 Pathophysiology of Bone Metastases....Pages 3-17 Natural History, Prognosis, Clinical Features and Complications of Metastatic Bone Disease....Pages 19-36 Pain in Bone Metastases: Types and Mechanisms....Pages 37-49 Front Matter....Pages 51-51 Radiological Evaluations: Radiography, CT, MRI....Pages 53-70 Nuclear Medicine Imaging Modalities: Bone Scintigraphy, PET-CT, SPECT-CT....Pages 71-94 Bone Biomarkers in Research and Clinical Practice....Pages 95-124 The Application of ‘Omics’ Techniques for Cancers That Metastasise to Bone: From Biological Mechanism to Biomarkers....Pages 125-153 Front Matter....Pages 155-155 Analgesic Treatment of Bone Metastases....Pages 157-173 External Beam Radiotherapy and Bone Metastases....Pages 175-185 Radionuclide Therapy....Pages 187-215 Bisphosphonates in Bone Metastatic Setting....Pages 217-234 New Targeted Therapies for Bone Metastases....Pages 235-246 Systemic Therapy of Bone Metastases....Pages 247-273 High-Intensity Focussed Ultrasound and Radio-Frequency Ablation for Bone Metastasis Treatment....Pages 275-300 Neuropathic Bone Metastases....Pages 301-308 Spinal Cord and Cauda Equina Compression....Pages 309-321 Pathological and Impending Fracture....Pages 323-340 Reirradiation....Pages 341-349 Challenges of Bone Metastases Treatment in Elderly Patients....Pages 351-363 Management of Metastatic Bone Disease in the Elderly with Bisphosphonates and RANKL Inhibitors: Effectiveness and Safety....Pages 365-379 Front Matter....Pages 381-381 Bone Metastases: Assessment of Therapeutic Response Using Radiological and Nuclear Medicine Imaging Modalities....Pages 383-405 Assessment of Therapeutic Response Through Clinical Assessment Measures....Pages 407-417 Outcome Measures in Bone Metastases Clinical Trials....Pages 419-439 Quality of Life in Patients Suffering from Metastatic Skeletal Disease....Pages 441-459 Front Matter....Pages 461-461 Cost Effectiveness of Treatment Modalities for Bone Metastases....Pages 463-480 Back Matter....Pages 481-490