Bone and Soft Tissue Pathology: A Volume in the Foundations in Diagnostic Pathology Series, Expert Consult - Online and Print

Bone and Soft Tissue Pathology: A Volume in the Diagnostic Pathology Series, by Andrew L. Folpe, MD and Carrie Y. Inwards, MD, packs today's most essential bone and soft tissue pathology know-how into a compact, high-yield format! The book's pragmatic, well-organized approach-complemented by abundant full-color, high-quality illustrations and at-a-glance tables-makes it easy to access the information you need to quickly and accurately identify pathology specimens. Best of all, Expert Consult functionality provides online access to the full text of the book, downloadable illustrations for your personal use, and more. The result is a practical, affordable reference for study and review as well as for everyday clinical practice. Includes access to the complete contents online, fully searchable, downloadable illustrations for your personal use, and more, allowing you to consult the text a quick, convenient manner. Reviews normal histology before examining abnormal findings, enabling you to conveniently compare their characteristics in one place at one time. Covers both neoplastic and non-neoplastic conditions of bone and soft tissue to equip you to meet a wide range of diagnostic challenges. Uses a consistent, user-friendly format to explore each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations...making it easy to locate specific information on a particular entity. Features abundant boxes and tables throughout that enhance the presentation and accessibility of the material. Offers nearly 1,000 full-color, high-quality illustrations that demonstrate the key features of a wide variety of pathologic lesions to facilitate greater accuracy in identification of specimens. The Foundations in Diagnostic Pathology Series answers the call for fresh, affordable, and easy-to-use guidance. Each region-specific volume provides all of the most essential information on the pathologic entities encountered in practice. Series Editor: John R. Goldblum, MD, FACP, FASCP, FACG Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued. Copyright page ......Page 2 Dedication ......Page 3 Contributors......Page 4 Foreword......Page 6 Preface......Page 7 History and Physical Examination......Page 8 Imaging Studies......Page 9 Laboratory Studies......Page 15 Grading of Soft Tissue Tumors......Page 18 Bone Tumor Grades (Summary)......Page 19 System of the American Musculoskeletal Tumor Society (Enneking System)......Page 20 IMMUNOHISTOCHEMISTRY IN THE DIFFERENTIAL DIAGNOSIS OF SMALL, BLUE, ROUND CELL TUMORS......Page 23 MONOMORPHIC SPINDLE CELL NEOPLASMS......Page 26 POORLY DIFFERENTIATED EPITHELIOID TUMORS......Page 27 PLEOMORPHIC SPINDLE CELL TUMORS......Page 28 OVERVIEW......Page 29 Reverse Transcriptase–Polymerase Chain Reaction......Page 31 Familial Syndromes......Page 33 Acquired Alterations......Page 37 Mutations with Diagnostic Significance......Page 38 Translocations......Page 34 Specific Translocations and Their Tumor Types......Page 35 Point Mutations......Page 40 Practical Significance of Mutation Detection in Sarcomas......Page 42 Clinical Features......Page 45 Microscopic Findings......Page 46 Variants of Nodular Fasciitis......Page 47 Immunohistochemistry ......Page 48 Microscopic Findings......Page 49 Differential Diagnosis......Page 51 Ancillary Studies......Page 52 Pathologic Features......Page 53 Differential Diagnosis ......Page 54 Pathologic Features......Page 55 Clinical Features......Page 56 Pathologic Features......Page 57 Ancillary Studies......Page 59 Pathologic Features......Page 60 Ancillary Studies......Page 61 Differential Diagnosis ......Page 62 Pathologic Features......Page 63 Ancillary Studies......Page 64 Pathologic Features......Page 65 Differential Diagnosis......Page 68 Prognosis and Treatment......Page 69 Pathologic Features......Page 71 Differential Diagnosis......Page 72 INTRODUCTION......Page 73 Pathologic Features......Page 74 Ancillary Studies......Page 75 Differential Diagnosis......Page 76 Ancillary Studies......Page 77 Prognosis and Treatment......Page 78 Pathologic Features......Page 79 Ancillary Studies......Page 80 Pathologic Features......Page 81 Genetics......Page 83 Differential Diagnosis......Page 84 ANGIOMATOID (MALIGNANT) FIBROUS HISTIOCYTOMA......Page 85 Ancillary Studies......Page 86 Differential Diagnosis......Page 87 Pathologic Features......Page 88 Differential Diagnosis......Page 89 Clinical Features......Page 90 Prognosis and Treatment......Page 91 UNDIFFERENTIATED PLEOMORPHIC SASARCOMA (So-Called Pleomorphic Malignant Fibrous Histiocytoma, Including Giant-Cell and Inflammatory Variants)......Page 92 Pathologic Features......Page 93 Differential Diagnosis......Page 94 Prognosis and Treatment......Page 95 Ancillary Studies......Page 99 Differential Diagnosis......Page 100 Prognosis and Treatment......Page 101 Pathologic Features......Page 102 Pathologic Features......Page 103 Prognosis and Treatment......Page 105 Pathologic Features......Page 106 MYOLIPOMA......Page 107 Prognosis and Treatment......Page 108 Pathologic Features......Page 109 Pathologic Features......Page 110 Ancillary Studies......Page 111 Prognosis and Treatment......Page 112 Ancillary Studies......Page 115 Ancillary Studies......Page 117 Prognosis and Treatment......Page 119 Pathologic Features......Page 121 Pathologic Features......Page 122 Pathologic Features......Page 123 Pathologic Features......Page 124 Differential Diagnosis......Page 125 Clinical Features......Page 126 Differential Diagnosis......Page 127 Pathologic Features......Page 128 Pathologic Features......Page 129 Differential Diagnosis......Page 130 Prognosis and Treatment......Page 131 Pathologic Features......Page 133 Differential Diagnosis......Page 134 Clinical Features......Page 135 Ancillary Studies......Page 136 Pathologic Features......Page 137 Differential Diagnosis......Page 139 Pathologic Features......Page 141 Differential Diagnosis......Page 142 Prognosis and Treatment......Page 143 Pathologic Features......Page 144 Differential Diagnosis......Page 145 ADULT SCLEROSING RHABDOMYOSARCOMA......Page 146 Pathologic Features......Page 148 Ancillary Studies......Page 149 Differential Diagnosis......Page 150 Pathologic Features......Page 152 Differential Diagnosis......Page 153 Prognosis and Treatment......Page 154 Pathologic Features......Page 155 ATYPICAL AND MALIGNANT GLOMUS TUMORS......Page 156 Ancillary Studies......Page 157 Prognosis and Treatment......Page 158 Microscopic Findings......Page 160 Ultrastructural Features......Page 161 DNADNASequencing......Page 162 Prognosis and Treatment......Page 163 Pathologic Features......Page 166 Differential Diagnosis......Page 167 Pathologic Features......Page 168 Clinical Features......Page 169 Pathologic Features......Page 170 Pathologic Features......Page 171 Differential Diagnosis......Page 173 Ancillary Studies......Page 174 Pathologic Features......Page 175 Differential Diagnosis......Page 176 Pathologic Features......Page 177 Differential Diagnosis......Page 178 Pathologic Features......Page 179 Differential Diagnosis......Page 180 Pathologic Features......Page 181 Ancillary Studies......Page 182 Pathologic Features......Page 183 Differential Diagnosis......Page 184 Pathologic Features......Page 185 Ancillary Studies......Page 186 Prognosis and Treatment......Page 187 Pathologic Features......Page 188 Differential Diagnosis......Page 189 Clinical Features......Page 190 Pathologic Features......Page 191 Differential Diagnosis......Page 192 Prognosis and Treatment......Page 193 Pathologic Features......Page 195 Pathologic Features......Page 197 Differential Diagnosis......Page 198 Clinical Features......Page 199 Ancillary Studies......Page 200 Clinical Features......Page 201 Pathologic Features......Page 202 Differential Diagnosis......Page 207 Clinical Features......Page 208 Pathologic Features......Page 209 Ancillary Studies......Page 211 Differential Diagnosis......Page 212 Clinical Features......Page 213 Prognosis and Treatment......Page 215 Pathologic Features......Page 216 Clinical Features......Page 219 Ancillary Studies......Page 221 Differential Diagnosis......Page 222 Pathologic Features......Page 224 Ancillary Studies......Page 225 Differential Diagnosis......Page 227 Clinical Features......Page 228 Pathologic Features......Page 229 Ancillary Studies......Page 231 Radiologic Features......Page 233 Differential Diagnosis......Page 234 Prognosis and Treatment......Page 237 Radiologic Images......Page 241 Pathologic Features......Page 242 Prognosis and Treatment......Page 243 Differential Diagnosis......Page 244 Pathologic Features......Page 245 Differential Diagnosis......Page 246 Radiologic Features......Page 247 Pathologic Features......Page 248 Radiologic Features......Page 249 Pathologic Features......Page 250 Prognosis and Treatment......Page 251 Radiologic Features......Page 252 Differential Diagnosis......Page 253 Pathologic Features......Page 254 Prognosis and Treatment......Page 255 TENOSYNOVIAL GIANT CELL TUMOR......Page 257 Radiologic Features......Page 258 Pathologic Features......Page 259 Prognosis and Treatment......Page 260 Ancillary Studies......Page 261 Differential Diagnosis......Page 262 Radiologic Features......Page 263 Differential Diagnosis......Page 264 Pathologic Features......Page 265 Clinical Features......Page 266 Prognosis and Treatment......Page 267 Radiologic Features......Page 268 Pathologic Features......Page 269 Pathologic Features......Page 270 Prognosis and Treatment......Page 271 MALIGNANT TENOSYNOVIAL GIANT CELL TUMOR......Page 272 Large Joint Detritic Synovitis......Page 273 Small Joint Detritic Synovitis......Page 275 Pathologic Features......Page 278 Clinical Features......Page 279 Differential Diagnosis......Page 280 Pathologic Features......Page 281 Prognosis and Treatment......Page 282 Pathologic Features......Page 283 Ancillary Studies......Page 284 Differential Diagnosis......Page 285 Prognosis and Treatment......Page 286 Differential Diagnosis......Page 287 Ancillary Studies......Page 289 Clinical Features......Page 290 Ancillary Studies......Page 291 PERIVASCULAR EPITHELIOID CELL NEOPLASMS......Page 292 Pathologic Features......Page 293 Differential Diagnosis......Page 294 Pathologic Features......Page 295 Differential Diagnosis......Page 296 Ancillary Studies......Page 297 Pathologic Features......Page 298 Differential Diagnosis......Page 299 Pathologic Features......Page 300 Ancillary Studies......Page 301 Differential Diagnosis......Page 302 Ancillary Studies......Page 303 Differential Diagnosis......Page 304 Radiologic Features......Page 308 Differential Diagnosis......Page 309 Pathologic Features......Page 310 Differential Diagnosis......Page 311 Clinical Features......Page 312 Pathologic Features......Page 313 Prognosis and Treatment......Page 314 Pathologic Features......Page 315 Differential Diagnosis......Page 317 OSTEOSARCOMA......Page 319 Radiologic Features......Page 320 Pathologic Features......Page 321 Ancillary Studies......Page 325 Prognosis and Treatment......Page 326 Clinical Features......Page 329 Pathologic Features......Page 330 Differential Diagnosis......Page 331 Pathologic Features......Page 332 Clinical Features......Page 333 Pathologic Features......Page 334 Differential Diagnosis......Page 335 Pathologic Features......Page 336 Differential Diagnosis......Page 337 Differential Diagnosis......Page 338 Ancillary Studies......Page 340 Pathologic Features......Page 341 Differential Diagnosis......Page 343 CHONDROSARCOMA VARIANTS......Page 344 Pathologic Features......Page 345 Prognosis and Treatment......Page 346 Pathologic Features......Page 347 Differential Diagnosis......Page 348 Pathologic Features......Page 349 Prognosis and Treatment......Page 351 Radiologic Features......Page 354 Differential Diagnosis......Page 355 Radiologic Features......Page 357 Pathologic Features......Page 358 Clinical Features......Page 359 Pathologic Features......Page 360 Differential Diagnosis......Page 361 Radiologic Features......Page 362 Pathologic Features......Page 363 Differential Diagnosis......Page 364 Radiologic Features......Page 366 Pathologic Features......Page 371 Ancillary Studies......Page 373 Differential Diagnosis......Page 375 Prognosis and Treatment......Page 376 Clinical Features......Page 378 Radiologic Features......Page 379 Pathologic Features......Page 380 Differential Diagnosis......Page 381 LYMPHOMA OF BONE......Page 382 Pathologic Features......Page 383 Ancillary Studies......Page 385 Differential Diagnosis......Page 386 HODGKIN LYMPHOMA OF BONE......Page 387 Pathologic Features......Page 388 Differential Diagnosis......Page 390 Radiologic Features......Page 391 Pathologic Features......Page 392 Ancillary Studies......Page 393 Differential Diagnosis......Page 394 Pathologic Features......Page 395 Ancillary Studies......Page 396 Differential Diagnosis......Page 397 Prognosis and Treatment......Page 398 Radiologic Features......Page 400 Differential Diagnosis......Page 402 Prognosis and Treatment......Page 404 Radiologic Features......Page 407 Pathologic Features......Page 408 Differential Diagnosis......Page 409 Prognosis and Treatment......Page 410 Pathologic Features......Page 413 Ancillary Studies......Page 414 Differential Diagnosis......Page 415 DIFFERENTIATED ADAMANTINOMA......Page 416 Radiologic Features......Page 418 Microscopic Findings......Page 419 Differential Diagnosis......Page 420 Pathologic Features......Page 423 Ancillary Studies......Page 425 Differential Diagnosis......Page 426 Radiologic Features......Page 427 Pathologic Features......Page 428 Differential Diagnosis......Page 430 SIMPLE (UNICAMERAL/SOLITARY) BONE CYST......Page 431 Pathologic Features......Page 432 Radiologic Features......Page 434 Differential Diagnosis......Page 435 Pathologic Features......Page 436 Ancillary Studies......Page 438 Differential Diagnosis......Page 439 Clinical Features......Page 440 Ancillary Studies......Page 441 Prognosis and Treatment......Page 443 Radiologic Features......Page 445 Immunohistochemistry......Page 448 Differential Diagnosis......Page 449 Prognosis and Treatment......Page 451 C......Page 453 E......Page 454 G......Page 455 L......Page 456 N......Page 457 S......Page 458 V......Page 459 X......Page 460 Bone And Soft Tissue Pathology: A Volume In The Diagnostic Pathology Series, By Andrew L. Folpe, Md And Carrie Y. Inwards, Md, Packs Today's Most Essential Bone And Soft Tissue Pathology Know-how Into A Compact, High-yield Format! The Book's Pragmatic, Well-organized Approach, Complemented By Abundant Full-color, High-quality Illustrations And At-a-glance Tables, Makes It Easy To Access The Information You Need To Quickly And Accurately Identify Pathology Specimens. Best Of All, Expert Consult Functionality Provides Online Access To The Full Text Of The Book, Downloadable Illustrations For Your Personal Use, And More. The Result Is A Practical, Affordable Reference For Study And Review As Well As For Everyday Clinical Practice. Includes Access To The Complete Contents Online, Fully Searchable, Downloadable Illustrations For Your Personal Use, And More, Allowing You To Consult The Text A Quick, Convenient Manner. Reviews Normal Histology Before Examining Abnormal Findings, Enabling You To Conveniently Compare Their Characteristics In One Place At One Time. Covers Both Neoplastic And Non-neoplastic Conditions Of Bone And Soft Tissue To Equip You To Meet A Wide Range Of Diagnostic Challenges. Uses A Consistent, User-friendly Format To Explore Each Entity's Clinical Features, Pathologic Features (gross And Microscopic), Ancillary Studies, Differential Diagnoses, And Prognostic And Therapeutic Considerations ... Making It Easy To Locate Specific Information On A Particular Entity. Features Abundant Boxes And Tables Throughout That Enhance The Presentation And Accessibility Of The Material. Offers Nearly 1,000 Full-color, High-quality Illustrations That Demonstrate The Key Features Of A Wide Variety Of Pathologic Lesions To Facilitate Greater Accuracy In Identification Of Specimens. Approach To The Diagnosis Of Bone And Soft Tissue Tumors : Clinical, Radiologic, And Classification Aspects / R. Lor Randall -- Adjuvant Techniques : Immunohistochemistry, Cytogenetics, And Molecular Genetics / Andrew L. Folpe, Enrique De Alava -- Fibroblastic And Fibrohistiocytic Tumors / Louis Guillou, Andrew L. Folpe -- Adipocytic Tumors / Angelo Paoli Dei Tos -- Smooth Muscle Tumors / Andrea T. Deyrup -- Skeletal Muscle Tumors / Raf Sciot -- Tumor Of Perivascular Cells / Andrew L. Folpe, Louis Guillou -- Gastrointestinal Stromal Tumor / Brian P. Rubin -- Vascular Tumors Of Soft Tissue / Andrew L. Folpe -- Nerve Sheath And Neuroectodermal Tumors / Julie C. Fanburg-smith -- Osteocartilaginous Tumors / John X. O'connell -- Tumors Of Synovial Tissue / G. Petur Nielsen, John X. O'connell -- Tumors Of Miscellaneous Type Or Uncertain Lineage / Andrew L. Folpe -- Bone-forming Tumors / G. Petur Nielsen, Andrew E. Rosenberg -- Cartilage-forming Tumors / Andrew Horvai -- Fibroblastic And Fibrohistiocytic Tumors / Edward F. Mccarthy -- Ewing's Sarcoma / Michael J. Klein -- Hematopoietic Tumors / Edward F. Mccarthy -- Vascular Tumors Of Bone / Andrew Horvai -- Giant Cell Tumor Of Bone / Patrizia Bacchini, Franco Bertoni -- Notochordal Tumors / Andrew Horvai -- Adamantinoma / Leonard B. Kahn -- Bone Tumors Of Miscellaneous Type Or Uncertain Lineage / S. Fiona Bonar -- Metastases Involving Bone / Yasuaki Nakashima. Edited By Andrew L. Folpe, Carrie Y. Inwards. Includes Bibliographical References And Index. Mode Of Access: World Wide Web. Approach to the diagnosis of bone and soft tissue tumors : clinical, radiologic, and classification aspects / R. Lor Randall Adjuvant techniques : immunohistochemistry, cytogenetics, and molecular genetics / Andrew L. Folpe, Enrique de Alava Fibroblastic and fibrohistiocytic tumors / Louis Guillou, Andrew L. Folpe Adipocytic tumors / Angelo Paoli Dei Tos Smooth muscle tumors / Andrea T. Deyrup Skeletal muscle tumors / Raf Sciot Tumor of perivascular cells / Andrew L. Folpe, Louis Guillou Gastrointestinal stromal tumors / Brian P. Rubin Vascular tumors of soft tissue / Andrew L. Folpe Nerve sheath and neuroectodermal tumors / Julie C. Fanburg-Smith Osteocartilaginous tumors / John X. O'Connell Tumors of synovial tissue / G. Petur Nielsen, John X. O'Connell Tumors of miscellaneous type or uncertain lineage / Andrew L. Folpe Bone-forming tumors / G. Petur Nielsen, Andrew E. Rosenberg Cartilage-forming tumors / Andrew Horvai Fibroblastic and fibrohistiocytic tumors / Edward F. McCarthy Ewing's sarcoma / Michael J. Klein Hematopoietic tumors / Edward F. McCarthy Vascular tumors of bone / Andrew Horvai Giant cell tumor / Patrizia Bacchini, Franco Bertoni Notochordal tumors / Andrew Horvai Adamantinoma / Leonard B. Kahn Bone tumors of miscellaneous type or uncertain lineage / Fiona Bonar Metastases involving bone / Yasuaki Nakashima. This book covers the most essential bone and soft tissue pathology know-how into a compact, high-yield format. The book's pragmatic, well-organized approachcomplemented by abundant full-color, high-quality illustrations and at-a-glance tablesmakes it easy to access the information you need to quickly and accurately identify pathology specimens. Reviews normal histology before examining abnormal findings, enabling you to conveniently compare their characteristics in one place at one time. Covers both neoplastic and non-neoplastic conditions of bone and soft tissue to equip you to meet a wide range of diagnostic challenges. Uses a consistent, user-friendly format to explore each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations ... making it easy to locate specific information on a particular entity. Features abundant boxes and tables throughout that enhance the presentatio