Blue Biotechnology: From Gene to Bioactive Product (Progress in Molecular and Subcellular Biology Book 55)

This book describes the discovery of molecules from unexploited extreme marine environments, and presents new approaches in marine genomics. It combines the current state of knowledge in marine genomics and advanced natural productsℓ́ℓ chemistry to pursue the sustainable production of novel secondary metabolites (lead compounds), as well as pharmacologically active peptides/proteins, with antimicrobial, neuroprotective, anti-osteoporotic, anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating effects. Further, it employs molecular-biology-based approaches and advanced chemical techniques to obtain and to select candidate compounds for pre-clinical and clinical studies Front Matter....Pages i-xi 35 Years of Marine Natural Product Research in Sweden: Cool Molecules and Models from Cold Waters....Pages 1-34 Major Antimicrobial Representatives from Marine Sponges and/or Their Associated Bacteria....Pages 35-89 Discovery and Development of Novel Drugs....Pages 91-104 Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity....Pages 105-158 Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification....Pages 159-186 New Target Sites for Treatment of Osteoporosis....Pages 187-219 Biocalcite and Carbonic Acid Activators....Pages 221-257 Electrospinning of Bioactive Wound-Healing Nets....Pages 259-290 Entotheonella Bacteria as Source of Sponge-Derived Natural Products: Opportunities for Biotechnological Production....Pages 291-314 "This book describes the discovery of molecules from unexploited extreme marine environments, and presents new approaches to marine genomics. It combines the current state of knowledge in marine genomics and advanced natural products' chemistry to pursue the sustainable production of novel secondary metabolites (lead compounds), as well as pharmacologically active peptides/proteins, with antimicrobial, neuroprotective, anti-osteoporotic, anti-protozoan/anti-plasmodial, antiageing and immune-modulating effects. Further, it employs molecularbiology-based approaches and advanced chemical techniques to obtain and to select candidate compounds for pre-clinical and clinical studies."--Page 4 of cover This book describes the discovery of molecules from unexploited extreme marine environments, and presents new approaches in marine genomics. It combines the current state of knowledge in marine genomics and advanced natural productsĺl chemistry to pursue the sustainable production of novel secondary metabolites (lead compounds), as well as pharmacologically active peptides/proteins, with antimicrobial, neuroprotective, anti-osteoporotic, anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating effects. Further, it employs molecular-biology-based approaches and advanced chemical techniques to obtain and to select candidate compounds for pre-clinical and clinical studies