Bisphosphonates In Clinical Oncology: The Development Of Pamidronate (recent Results In Cancer Research)

This book provides a clinically oriented overview on the patho-physiological background and the use of bisphosphonates in oncology. The clinical development of pamidronate to treat tumor-induced hypercalcemia and malignant osteolytic bone disease is demonstrated, as well as the results of pivotal studies. New important findings on how to best use pamidronate in certain indications are given and put in perspective. The author discusses patient management guidelines as well as pharmaco-economic aspects important for the readers. Front Matter....Pages I-XIV Physiology and Pathophysiology of Bone....Pages 1-20 Pharmacological Treatment of Bone Disorders....Pages 21-57 Pamidronate....Pages 59-106 Recent Developments and Future Directions....Pages 107-113