Bipolar Disorder: The Upswing in Research and Treatment (European Foundation for Psychiatry at the Maudsley)

"This book focuses on the recent surge in research into the pathogenesis and treatment of bipolar disorder, and critically analyses the evidence supporting many of the conventional opinions about the disease. Chapters by leading basic science and clinical researchers from North America and Europe address issues including the very nature of the disease (psychological disorder or brain disease), the role of genetics, the role of cortisol, and the effects of long-term treatment. Based on lectures presented as part of the second European Foundation for Psychiatry at the Maudsley (EFPM) meeting, this book will stimulate discussion and debate on novel views and will question the dogmas of existing practice."--Jacket Section 1. Do We Know The Clinical Course And Epidemiology? -- The Clinical Epidemiology Of Bipolar Disorder: A 35-year Incidence Study In South-east London / Noel Kennedy, Robin M Murray -- The Functional Outcome Of Bipolar Disorder / Mauricio Tohen, Julie M Niswander -- Section 2. Is Bipolar Disorder A Brain Disease? -- Brain Abnormalities In Bipolar Disorder: Do They Exist And Do They Change? / E Serap Monkul, Jair C Soares -- Structural Magnetic Resonance Imaging Studies In Bipolar Disorder: A Meta-analysis / Colm Mcdonald, Jolanta Zanelli, Robin M Murray, Noel Kennedy -- Are Subcortical Regions Too Expansive In Bipolar Disorder? An Examination Of The Nature Of Prefrontal Corticolimbic Abnormalities In Individuals With Bipolar Disorder / Mary L Phillips -- The Maudsley Bipolar Disorder Project: Insights Into Pathophysiology / Sophia Frangou -- Is Any Of This Real? The Word From The Grave / Paul J Harrison. Section 3. Happy Genes, Blue Genes, Any Genes? -- How Can Bipolar Disorder Be Genetically Related To Both Schizophrenia And Unipolar Depression? / Peter Mcguffin -- Recent Advances In Genetics Of Bipolar Disorder / Daniel J Muller, James L Kennedy -- Is There A Genetic Basis To The Brain Abnormalities Of Bipolar Disorder? / Colm Mcdonald -- Transgenic Mouse Models For Affective Disorders Based On The Neurotrophin Hypothesis / Peter Gass -- Section 4. Cortisol: Hero Or Villain? -- Is The Hypothalamic-pituitary-adrenal Axis At Last Paying Dividends? / David A Cousins, Allan H Young -- Stress On The Brain: Neuropathology And Cortisol Dysregulation In Bipolar Disorder / David Cotter -- Cortisol In Chicago (from Crime Of Passion To Celebrity Headline) / Carmine M Pariante -- Biological Factors Sustaining Hypothalamic-pituitary-adrenal Axis Overactivation In Affective Disorder: Focus On Vasopressin / Timothy G Dinan, Sinead O'brien, Lucinda Scott. Section 5. What Is The Role Of Psychology? -- Cognitive Dysfunction: Cause Or Consequence Of Bipolar Disorder? / Samuel R Chamberlain, Barbara J Sahakian -- The Neural Basis Of Cognitive Function In Bipolar Disorder / Vivienne Curtis -- Psychological Treatments: Does The Evidence Stack Up? / Jan Scott -- Section 6. Improving The Patient's Lot -- Lithium, The Forgotten Drug / Mario Maj -- Advantages And Disadvantages Of Atypical Antipsychotics Or Valproate In Bipolar Disorder / John Cookson -- Is Electroconvulsive Therapy Still Given In Bipolar Disorder And Does Repetitive Transcranial Magnetic Stimulation Offer More? / Andrew Mogg, Savitha Eranti, Graham Pluck, Declan M Mcloughlin -- Improving Outcome By Selecting Effective Long-term Treatment / Paul Grof -- Is What We Offer To Patients Half Acceptable? / Rachel Perkins. Edited By Colm Mcdonald ... [et Al.]. Includes Bibliographical References And Index. Contents......Page 6 Preface......Page 10 Foreword......Page 14 Contributors......Page 16 chapter 1. The clinical epidemiology of bipolar disorder: a 35-year incidence study in south-east London......Page 20 chapter 2. The functional outcome of bipolar disorder......Page 28 chapter 3. Brain abnormalities in bipolar disorder: do they exist and do they change?......Page 40 chapter 4. Structural magnetic resonance imaging studies in bipolar disorder: a meta-analysis......Page 46 chapter 5. Are subcortical regions too explansive in bipolar disorder?......Page 56 chapter 6. The Maudsley Bipolar Disorder Project: insights into pathophysiology......Page 70 chapter 7. Is any of this real? The word from the grave......Page 78 chapter 8. How can bipolar disorder be genetically related to both schizophrenia and unipolar depression?......Page 88 chapter 9. Recent advances in genetics of bipolar disorder......Page 96 chapter 10. Is there a genetic basis to the brain abnormalities of bipolar disorder?......Page 112 chapter 11. Transgenic mouse models for affective disorders based on the neurotrophin hypothesis......Page 122 chapter 12. Is the hypothalamic-pituitary-adrenal axis at last paying dividends?......Page 134 chapter 13. Stress on the brain: neuropathology and cortisol dysregulation in bipolar disorder......Page 142 chapter 14. Cortisol in Chicago (from crime of passion to celebrity headline)......Page 148 chapter 15. Biological factors sustaining hypothalamic-pituitary-adrenal axis overactivation in affective disorder: focus on vasopressin......Page 154 chapter 16. Cognitive dysfunction: cause or consequence of bipolar disorder?......Page 164 chapter 17. The neural basis of cognitive function in bipolar disorder......Page 176 chapter 18. Psychological treatments: does the evidence stack up?......Page 184 chapter 19. Lithium, the forgotten drug......Page 194 chapter 20. Advantages and disadvantages of atypical antipsychotics or valproate in bipolar disorder......Page 200 chapter 21. Is electroconvulsive therapy still given in bipolar disorder and does repetitive transcranial magnetic stimulation offer more?......Page 212 chapter 22. Improving outcome by selecting effective long-term treatment......Page 220 chapter 23. Is what we offer to patients half acceptable?......Page 230 Index......Page 238