Biothiols in Health and Disease (Antioxidants in Health and Disease Series, 2)

This unique, state-of-the-art reference presents a detailed account of the molecular mechanisms underlying the multiple functions of biothiols-emphasizing the biological and clinical implications of interactions between oxidants and biothiols. Series Introduction / Lester Packer And Jurgen Fuchs -- I. Thiols And Thiyl Radicals: Chemical And Biochemical Aspects. 1. Reactions Of Thiyl Radicals / Peter Wardman. 2. Thiyl Radicals, Perthiyl Radicals, And Oxidative Reactions / Christian Schoneich. 3. Antioxidant Drug Design: A Comparison Of Thiol And Perthiol Antiradical And Prooxidant Mechanisms / Steven A. Everett. 4. Biothiyls: Free Radical Chemistry And Biological Significance / Janice A. Degray And Ronald P. Mason. 5. Peroxynitrite Reactivity: Free Radical Generation, Thiol Oxidation, And Biological Significance / Ohara Augusto And Rafael Radi. 6. Concerted Antioxidant Activity Of Glutathione And Superoxide Dismutase / Christine C. Winterbourn. 7. Glutathione-dependent Bioactivation Of Xenobiotics / M.w. Anders, Wolfgang Dekant And Spyridon Vamvakas -- Ii. Thiols And Oxidative Stress. 8. Strategies For Increasing Cellular Glutathione / Alton Meister. Edited By Lester Packer, Enrique Cadenas. Includes Bibliographical References And Index.