Biotechnology: Products of Secondary Metabolism, Volume 7, Second Edition

Products of secondary metabolism from fermentation and cell culture are mainly pharmaceuticals, ranging from traditional antibacterials like beta-lactams, new generation compounds like dalbaheptides and lantibiotics to immunomodulators and antitumor drugs. The major fields of application of these low volume/high price products are human and veterinary medicine as well as plant protection. In this volume functionally based screening approaches and the applications of molecular genetics in the discovery and process improvement of compounds are emphasized. Along with the exploitation of new sources the growing understanding of biosynthetic processes permits the identification of the genetic backgrounds. Topics included are: Novel Receptor-Active Compounds - Microbial Lipids - Microbial Siderophores - beta-Lactam Antibiotics - Peptide Antibiotics - Lantibiotics - Glycopeptide Antibiotics (Dalbaheptides) - Aminoglycosides - Products from Basidiomycetes - Cyclosporins - Secondary Products from Plant Cells - Antitumor Agents Content: Chapter 1 General Aspects of Secondary Metabolism (pages 1–55): Hans von Dohren and Udo Grafe Chapter 2 Regulation of Bacterial Antibiotic Production (pages 57–105): Keith F. Chater and Mervyn J. Bibb Chapter 3 Screening of Novel Receptor?Active Compounds of Microbial Origin (pages 107–132): Haruo Tanaka and Satoshi Omura Chapter 4 Microbial Lipids (pages 133–197): Colin Ratledge Chapter 5 Microbial Siderophores (pages 199–246): Gunther Winkelmann and Hartmut Drechsel Chapter 6 Advances in the Molecular Genetics of ??Lactam Antibiotic Biosynthesis (pages 247–276): Paul L. Skatrud, Torsten Schwecke, Henk Van Liempt and Matthew B. Tobin Chapter 7 Peptide Antibiotics (pages 277–322): Horst Kleinkauf and Hans von Dohren Chapter 8 Lantibiotics (pages 323–368): Ralph Jack, Friedrich Gotz and Gunther Jung Chapter 9 Glycopeptide Antibiotics (Dalbaheptides) (pages 369–396): Giancarlo Lancini and Bruno Cavalleri Chapter 10 Aminoglycosides and Sugar Components in Other Secondary Metabolites (pages 397–488): Wolfgang Piepersberg and Jurgen Distler Chapter 11 Products from Basidiomycetes (pages 489–533): Gerhard Erkel and Timm Anke Chapter 12 Cyclosporins: Recent Developments in Biosynthesis, Pharmacology and Biology, and Clinical Applications (pages 535–591): Jorg Kallen, Vincent Mikol, Valerie F. J. Quesniaux, Malcolm D. Walkinshaw, Elisabeth Schneider?Scherzer, Kurt Schorgendorfer, Gerhard Weber and Hans G. Fliri Chapter 13 Secondary Products from Plant Cell Cultures (pages 593–640): Jochen Berlin Chapter 14 Biotechnical Drugs as Antitumor Agents (pages 641–705): Udo Grafe, Klausjurgen Dornberger and Hans?Peter Saluz v. 1. Biological fundamentals / edited by H. Sahm v. 2. Genetic fundamentals and genetic engineering / edited by A. Pühler v. 3. Bioprocessing / edited by G. Stephanopoulos v. 4. Measuring, modelling, and control / edited by K. Schügerl v. 5a. Recombinant proteins, monoclonal antibodies, and therapeutic genes / edited by A. Mountain, U. Ney, and D. Schomburg v. 5b. Genomics and bioinformatics / edited by C.W. Sensen v. 7. Products of secondary metabolism / edited by H. Kleinkauf and H. von Döhren v. 8a. Biotransformation I / edited by D.R. Kelly v. 8b. Biotransformation II / vol. editor, D.R. Kelly v. 10. Special processes / edited by H.-J. Rehm v. 11a. Environmental processes I : wastewater treatment / edited by J. Winter llb. Environmental processes II : soil decontamination / edited by J. Klein 11c. Environmental processes III : solid waste and waste gas treatment, preparation of drinking water / edited by J. Klein and J. Winter v. [13]. Cumulative index/ edited by H.-J. Rehm and G. reed in cooperation with A. Pühler and P. Stadler.