Biotechnology of Filamentous Fungi: Technology and Products (The Biotechnology Series)

Biotechnology of Filamentous Fungi: Technology and Products provides a comprehensive discussion of the molecular biology, genetics, and biochemistry of filamentous fungi. It also deals with general principles of biochemical engineering such as process design and scaleup. The book's main emphasis, however, is on the commercial significance of filamentous fungi. The book highlights the unique aspects of filamentous fungi along with those aspects common to most microorganisms studied in industries that use biotechnology. Filamentous fungi can generate a wide range of industrial products including primary metabolites such as organic acids, secondary metabolites such as ß-lactam antibiotics, nonantibiotic drugs, and enzymes for use in food production. Whole organisms such as mushrooms can be used as well as organisms used as insecticides and herbicides. Filamentous fungi also qualify as potential hosts for the secretion of certain heterogeneous proteins such as mammalian proteins. However, not all things related to fungi are beneficial. Mycotoxins products by fungi can be lethal to humans; there is also a need to develop antifungal agents to destroy fungi that can kill animals and plants. These topics are important aspects of the biotechnology of filamentous fungi and are dealt with in this text. Content: BIOTECHNOLOGY , Page ii , JULIAN E. DAVIES BIOTECHNOLOGY SERIES , Pages iii-iv Front Matter , Page v Copyright , Page vi CONTRIBUTORS , Pages vii-viii ACKNOWLEDGMENTS , Page xv CHAPTER 1 - Editorial Introduction , Pages 1-4 , David B. Finkelstein, Christopher Ball CHAPTER 2 - Isolation, Preservation, and Taxonomy , Pages 7-39 , Kerry O'Donnell, Stephen W. Peterson CHAPTER 3 - Strain Improvement and Strain Stability , Pages 41-64 , Robert T. Rowlands CHAPTER 4 - Growth Kinetics and Fermentation Scaleup , Pages 65-87 , Randolph L. Greasham CHAPTER 5 - Regulation of Secondary Metabolism , Pages 89-112 , Arnold L. Demain CHAPTER 6 - Transformation , Pages 113-156 , David B. Finkelstein CHAPTER 7 - Bioconversions , Pages 157-187 , Herbert L. Holland CHAPTER 8 - Screening for Antifungal Drugs , Pages 189-217 , Claude P. Selitrennikoff CHAPTER 9 - Molecular Biology and Biochemistry of the β-Lactam Antibiotics , Pages 221-239 , John A. Rambosek CHAPTER 10 - Therapeutic Metabolites , Pages 241-301 , Prakash S. Masurekar CHAPTER 11 - Organic Acids , Pages 303-334 , Mary Jo Zidwick CHAPTER 12 - Insecticides and Herbicides , Pages 335-359 , Wayne A. Gardner, Clayton W. McCoy CHAPTER 13 - Food Enzymes , Pages 361-415 , Ramunas Bigelis CHAPTER 14 - Structure, Function, and Genetics of Cellulases , Pages 417-445 , Tuula T. Teeri, Merja Penttilä, Sirkka Keränen, Helena Nevalainen, Jonathan K.C. Knowles CHAPTER 15 - Edible Mushrooms , Pages 447-462 , Paul A. Horgen, James B. Anderson CHAPTER 16 - Mycotoxins , Pages 463-503 , L.S. Lee, P. Bayman, J.W. Bennett INDEX , Pages 505-520 A comprehensive introduction to fungal biotechnology covering fungi isolation and characterization, strain improvement, and fermentation scale-up, thus equipping the non-specialist with the principles needed to discover and develop new fungal products. The versatility of these organisms in their application to both traditional and modern purposes is illustrated. Annotation copyright Book News, Inc. Portland, Or.