Biotechnology of Antibiotics (Drugs and the Pharmaceutical Sciences)

Specifically Addressing Microbially Derived Commercially Important Bioactive Products That Are Currently Or Soon To Be Available, Biotechnology Of Antibiotics, Second Edition Analyzes The Use Of Recombinant Enzymes To Produce Biologically Active Molecules, Including A Cholesterol-lowering Agent, An Anti-hiv Drug For The Treatment Of Aids, And [beta]-lactam Antibiotics...gives Insight Into The Biochemistry, Molecular Biology, And Production Of Antibiotics Used As Therapeutic Agents...focuses On State-of-the-art Techniques For The Development Of New Antibiotics Using Novel Approaches And Strategies...highlights Recent Advances In The Genetic Manipulation Of Antibiotic Biosynthesis Genes To Create Structures From Gene Combinations For New Biological Activities...describes In Detail The Development And Current Status Of Newly Created Antibiotics And Pharmacologically Active Natural Products...and Much More.--book Jacket. Pt. I. Introduction And Approaches For Improvement In Antibiotic Production -- 1. Industrial Antibiotics: Today And The Future / William R. Strohl -- 2. Molecular Genetic Approaches To Yield Improvement In Actinomycetes / Richard H. Baltz -- 3. Butyrolactone Autoregulators, Inducers Of Virginiamycin To Streptomyces Virginiae: Their Structures, Biosynthesis, Receptor Proteins, And Induction Of Virginiamycin Biosynthesis / Yasuhiro Yamada, Takuya Nihira And Shohei Sakuda -- Pt. Ii. Aminoglycosides -- 4. Molecular Biology, Biochemistry, And Fermentation Of Aminoglycoside Antibiotics / Wolfgang Piepersberg -- 5. Fermentation, Biosynthesis, And Molecular Genetics Of Lincomycin / Shiau-ta Chung, Jack J. Manis And Steven J. Mcwethy -- Pt. Iii. Template-biosynthesized Peptide And [beta]-lactam Antibiotics -- 6. Structure, Function, And Regulation Of Genes Encoding Multidomain Peptide Synthetases / Peter Zuber And Mohamed A. Marahiel --^ 7. Enzymology Of Peptide Synthetases / Hans Von Dohren And Horst Kleinkauf -- 8. Comparative Genetics And Molecular Biology Of [beta]-lactam Biosynthesis / Ashish S. Paradkar, Susan E. Jensen And Roy H. Mosher -- 9. Biosynthesis Of Cyclosporins / Rene Traber -- 10. Echinocandin Antifungal Agents / William W. Turner And William L. Current -- 11. Biochemistry And Genetics Of Actinomycin Production / George H. Jones And Ullrich Keller -- 12. Vancomycin And Other Glycopeptides / Thalia I. Nicas And Robin D. G. Cooper -- 13. Thiopeptide Antibiotics / Todd M. Smith, Ya-fen Jiang And Heinz G. Floss -- 14. Lipopeptide Antibiotics Produced By Streptomyces Reseosporus And Streptomyces Fradiae / Richard H. Baltz -- Pt. Iv. Ribosomally Synthesized Peptide Antibiotics -- 15. Nisin And Related Antimicrobial Peptides / J. Norman Hansen -- 16. Cationic Peptides / Robert E. W. Hancock And Timothy John Falla -- Pt. V. Polyketide Antibiotics Produced By Type-i Multifunctional Enzymes --^ 17. Rapamycin, Fk506, And Ascomycin-related Compounds / Kevin A. Reynolds And Arnold L. Demain -- 18. Rifamycins / Giancarlo Lancini And Bruno Cavalleri -- 19. Polyene Antibiotics / Jose A. Gil And Juan F. Martin -- Pt. Vi. Polyketide Antibiotics Produced By Type-ii Polyketide Synthase Systems -- 20. Anthracyclines / William R. Strohl, Michael L. Dickens And Vineet B. Rajgarhia -- 21. Tetracyclines / Iain S. Hunter And Robert A. Hill -- 22. Antibiotics From Genetically Engineered Microorganisms / C. Richard Hutchinson -- Pt. Vii. Peptidyl Nucleoside Antibiotics -- 23. Blasticidin S And Related Peptidyl Nucleoside Antibiotics / Steven J. Gould -- Pt. Viii. Recombinant Bioconversions Of Bioactive Molecules -- 24. New Processes For Production Of 7-aminocephalosporanic Acid From Cephalosporin / Takao Isogai -- 25. Chemoenzymatic Production Of The Antiviral Agent Epivir / Mahmoud Mahmoudian And Michael J. Dawson --^ 26. Biochemical And Fermentation Technological Approaches To Production Of Pravastatin, A Hmg-coa Reductase Inhibitor / Nobofusa Serizawa, Masahiko Hosobuchi And Hiroji Yoshikawa. Edited By William R. Strohl. Rev. Of: Biotechnology Of Industrial Antibiotics / Edited By Erick J. Vandamme. C1984. Includes Bibliographical References And Index. This incomparable Second Edition of a highly regarded reference has been entirely rewritten and enlarged to reflect the explosion of information and technologies that have emerged since the publication of the previous edition. Strikes the perfect balance between proven traditional approaches and modern methods that promise to yield new products and processes Specifically addressing microbially derived commercially important bioactive products that are currently or soon-to-be available, Biotechnology of Antibiotics, Second Edition analyzes the use of recombinant enzymes to produce biologically active molecules, including a cholesterol-lowering agent, an anti-HIV drug for the treatment of AIDS, and b-lactam antibiotics gives insight into the biochemistry, molecular biology, and production of antibiotics used as therapeutic agents focuses on state-of-the-art techniques for the development of new antibiotics using novel approaches and strategies highlights recent advances in the genetic manipulation of antibiotic biosynthesis genes to create structures from gene combinations for new biological activities describes in detail the development and current status of newly created antibiotics and pharmacologically active natural products and much more Written by authorities from both industry and academia and containing nearly 4000 bibliographic citations, Biotechnology of Antibiotics, Second Edition is an outstanding resource for pharmaceutical scientists, medicinal chemists and biochemists, molecular biologists and industrial microbiologists, chemical engineers, fermentation bioengineers, bioprocess technologists, and upper-level undergraduate and graduate students in these disciplines.