Biotechnology and Biopharmaceuticals : Transforming Proteins and Genes Into Drugs

Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs defines biotechnology from the perspective of pharmaceuticals. The first section focuses on the process of transforming a biologic macromolecule into a therapeutic agent, while the second section provides a brief overview of each class of macromolecule with respect to physiological role and clinical application. Additional detail is also provided in the second section for each FDA approved, recombinantly derived biopharmaceutical for each category of macromolecule. The final section looks to the future and the new advances that will enhance our ability to develop new macromolecules into effective biopharmaceuticals. This last section discusses various drug delivery strategies while also describing gene and cell therapy strategies. The First Of This Book's Three Sections Focuses On The Process Of Transforming A Macromolecule Into A Therapeutic Agent; The Second Provides A Brief Overview Of Each Class Of Macromolecule With Respect To Physiological Role And Clinical Application. The Second Section Also Provides Additional Detail For Each Fda Approved Biopharmaceutical. The Final Section Looks To New Advances That Will Enhance Our Ability To Develop New Macromolecules Into Effective Biopharmaceuticals. Introduction To Biopharmaceuticals -- Comparative Drug Development Of Proteins And Genes Versus Small Molecules -- Biotechnology Industry Perspective On Drug Development -- Biopharmaceutical Technologies And Processes In Drug Development -- Pharmacology, Toxicology, Therapeutic Dosage Formulations, And Clinical Response -- Hematopoietic Growth Factors And Coagulation Factors -- Interferons And Cytokines For Anti-infective And Cancer Therapy -- Hormones -- Enzymes -- Antibodies And Derivatives -- Vaccines -- Other Products : Monographs -- Advanced Drug Delivery. Individualization Of Drug Regimens : Integration Of Pharamacokinetic And Pharmacogenic Principles In Drug Therapy -- Gene And Cell Therapy -- Integration Of Discovery And Development : The Role Of Genomics And Proteomics. Rodney J.y. Ho, Milo Gibaldi. Includes Bibliographical References And Index. Also Available In An Electronic Version. Mode Of Access: World Wide Web. To help scientists and healthcare professionals keep pace with developments in bioengineered drugs, Ho and Gibaldi (U. of Washington School of Pharmacy, Seattle) introduce monographs on biopharmaceutical technologies and processes, therapies based on biotechnology, and future directions (e.g, individualized gene- based medicine)-while acknowledging that biotechnology is anathema to some. Appended tables summarize technical data and information on therapeutic use and nomenclature. An auxiliary Web site is available. Biopharmaceutics is the study of how pharmaceutical properties affect biologic properties and therapeutic usefulness. Biotechnology describes the industry of creating, developing, and marketing products through the manipulation, on a molecular level, of life forms or utilization of knowledge pertaining to living systems. Since the discovery in 1800 that the human body is composed of cells and proteins that are susceptible to but can also fight off pathogenic microbes, the perceived battlefield has challenged our imagination to develop biopharmaceuticals-biologically based therapeutic products.