Bioreduction in the Activation of Drugs : Proceedings of the Second Biochemical Pharmacology Symposium, Oxford, UK, 25-26 July 1985

Bioreduction in the Activation of Drugs covers the proceedings of the Second Biochemical Pharmacology Symposium. The book presents papers that cover the applications of bioreduction in drug activation, along with its concerns. The text first presents materials about enzymology, such as overview of enzyme systems involved in bioreduction of drugs and in redox cycling, and reductive role of glutathione in the redox cycling of oxidizable drugs. Next, the book covers papers on bacterial and parasites infection, which include reduction by the gut microflora of animals and human and reduction of nitroimidazoles in vitro and DNA damage. The remaining articles deal with cancer treatment, such as hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer, and the biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms. The text will be of great use to researchers and practitioners of medicine, pharmacology, and biochemistry. Content: Pergamon Titles of Related Interest , Page ii Inside Front Cover , Page iia Front Matter , Page iii Copyright , Page iv OVERVIEW OF ENZYME SYSTEMS INVOLVED IN BIO-REDUCTION OF DRUGS AND IN REDOX CYCLING , Pages 1-6 , H. KAPPUS REGULATION OF REDUCTIVE PROCESSES BY GLUTATHIONE , Pages 7-13 , DONALD J. REED THE CRUCIAL ROLE OF LOW STEADY STATE OXYGEN PARTIAL PRESSURES IN HALOALKANE FREE-RADICAL-MEDIATED LIPID PEROXIDATION: POSSIBLE IMPLICATIONS IN HALOALKANE LIVER INJURY , Pages 15-19 , HERBERT DE GROOT, THOMAS NOLL Reductive role of glutathione in the redox cycling of oxidizable drugs , Pages 21-22 , IAN WILSON, PETER WARDMAN, GERALD M. COHEN, MARY D'ARCY DOHERTY Generation of photoemissive species during quinone redox cycling , Pages 22-24 , HERIBERT WEFERS, HELMUT SIES Chairman's Summary of Session A , Page 25 , V. ULLRICH REDUCTION BY THE GUT MICROFLORA OF ANIMALS AND MAN , Pages 27-32 , IAN R. ROWLAND THE METABOLIC ACTIVATION OF RONIDAZOLE [(1-METHYL-5-NITROIMIDAZOLE-2-YL)-METHYL CARBAMATE] TO REACTIVE METABOLITES BY MAMMALIAN, CECAL BACTERIAL AND T. FOETUS ENZYMES , Pages 33-36 , GERALD T. MIWA, REGINA WANG, RAUL ALVARO, JOHN S. WALSH, ANTHONY Y.H. LU REDUCTIVE ACTIVATION OF NITROIMIDAZOLES IN ANAEROBIC MICROORGANISMS , Pages 37-41 , MIKL S MÜLLER COMPARING THE REDUCTION OF NITROIMIDAZOLES IN BACTERIA AND MAMMALIAN TISSUES AND RELATING IT TO BIOLOGICAL ACTIVITY , Pages 43-51 , PETER GOLDMAN, RONALD L. KOCH, TIN-CHUEN YEUNG, EWAN J.T. CHRYSTAL, BERNARD B. BEAULIEU JR., MARTHA A. MCLAFFERTY, GILLIAN SUDLOW REDUCTION OF NITROIMIDAZOLES IN VITRO AND DNA DAMAGE , Pages 53-58 , DAVID I. EDWARDS In vitro reductive activation of nitroimidazoles , Pages 59-61 , P.J. DECLERCK, C.J. DE RANTER Inhibition of hydrogen production in drug-resistant and susceptible Trichomonas vaginalis strains by a range of nitroimidazole derivatives , Pages 61-64 , D. LLOYD, N. YARLETT, N.C. YARLETT The role of the gut flora in the reduction of sulphoxide containing drugs , Page 64 , A.G. RENWICK, H.A. STRONG, C.F. GEORGE Chairman's Summary of Session B , Page 65 , D. LLOYD THE ROLE OF MITOMYCIN ANTIBIOTICS IN THE CHEMOTHERAPY OF SOLID TUMORS , Pages 67-69 , ALAN C. SARTORELLI HYPOXIA-MEDIATED NITRO-HETEROCYCLIC DRUGS IN THE RADIO- AND CHEMOTHERAPY OF CANCER AN OVERVIEW , Pages 71-76 , G.E. ADAMS, I.J. STRATFORD BIOCHEMISTRY OF REDUCTION OF NITRO HETEROCYCLES , Pages 77-90 , JOHN E. BIAGLOW, MARIE E. VARNES, LAURIE ROIZEN-TOWLE, EDWARD P. CLARK, EDWARD R. EPP, MYLES B. ASTOR, ERIC J. HALL Toxicity of oxygen at amospheric concentration for newly explanted cancer cells , Pages 91-92 , PETER ALEXANDER, PAUL V. SENIOR The effect of bioreduction on the oncogenicity of nitroimidazoles , Pages 93-94 , ERIC J. HALL, TOM K. HEI Chairman's Summary of Session C , Pages 95-96 , ERIC J. HALL THE BIOLOGICAL PROPERTIES OF REDUCED NITROHETEROCYCLICS AND POSSIBLE UNDERLYING BIOCHEMICAL MECHANISMS , Pages 97-103 , G.F. WHITMORE, A.J. VARGHESE RSU 1069, A NITROIMIDAZOLE CONTAINING AN AZIRIDINE GROUP: BIOREDUCTION GREATLY INCREASES CYTOTOXICITY UNDER HYPOXIC CONDITIONS , Pages 105-109 , IAN J. STRATFORD, PETER O'NEILL, PETER W. SHELDON, ANDREW R.J. SILVER, JACQUELINE M. WALLING, GERALD E. ADAMS SENSITIZATION OF CANCER CHEMOTHERAPEUTIC AGENTS BY NITROHETEROCYCLICS , Pages 111-115 , DIETMAR W. SIEMANN, R. TIMOTHY MULCAHY Benznidazole: nitroreduction and inhibition of cytochrome P-450 in chemosensitization of tumour response to cytotoxic drugs , Pages 117-119 , PAUL WORKMAN, MICHAEL I. WALTON, FRANCIS Y.F. LEE Chairman's Summary of Session D , Pages 121-122 , T.A. CONNORS Editors, P. Alexander, J. Gielen, A.c. Sartorelli. Published As Volume 35, Number 1, Of The Journal Biochemical Pharmacology--t.p. Verso. Includes Bibliographies.