Biomedical Engineering Systems and Technologies: Third International Joint Conference, BIOSTEC 2010, Valencia, Spain, January 20-23, 2010, Revised ... in Computer and Information Science, 127)

This book constitutes the thoroughly refereed post-conference proceedings of the Third International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2010, held in Valencia, Spain, in January 2010. The 30 revised full papers presented together with 1 invited lecture were carefully reviewed and selected from a total of 410 submissions in two rounds of reviewing and improvement. The papers cover a wide range of topics and are organized in four general topical sections on healthinf, biodevices, biosignals, and bioinformatics. Title Preface Organization Table of Contents Invited Papers Personal Health:The New Paradigm to Make Sustainable the Health Care System Introduction Telemedicine and Health New Paradigm for Health Care Systems Disruptive Innovation Chronic Disease Challenge Personal Health Systems Information and Communication Technologies (ICT) RFID Sensors Internet 2.0 Electronic Health Records Ambient Intelligence Conclusions References Part I Health Informatics Registration and Fusion Techniques for Medical Images: Demonstration and Evaluation Introduction System Architecture Data Collection and Data Management Subsystem Medical Data Preprocessing Subsystem Medical Data Alignment Subsystem Medical Data Fusion Subsystem Graphical Interface Subsystem Working Environment Pilot Scenario Quantitative Analysis of Registration Results Three-Dimensional Display of Anatomic Structures Conclusions References Prediction of Pancreatic Cancer Survival through Automated Selection of Predictive Models Introduction Machine Learning Classical Meta-learning Proposed Automated Model Selection Meta-learning Approach Plan of the Paper Pancreatic Cancer Clinical Datasets Pre-operative and All-attributes Predictive Attribute Sets Prediction Target Attribute Summary of Datasets Considered Learning to Predict the Best Performing Model Model Selection Meta-learning for Prediction Training the Model Selection Metalearner Evaluation Preprocessing and Predictive Techniques Used Experimental Protocol Results and Discussion Conclusions References Web of Active Documents: An Architecture for Flexible Electronic Patient Records Motivations and Background Webs of Active Documents Datoms, Didgets and Templates Mechanisms in the WOAD Framework Interaction with the WOAD Architecture Conclusions and Future Work References A Personalization Environment for Multi-version Clinical Guidelines Introduction Versioning of Clinical Guidelines Temporal Versioning Semantic Versioning An XML Data Model for Multi-version Guidelines Manipulation and Retrieval Operations Prototype Implementation Conclusions and Future Work References Dynamic Routing Using Health Information Policy with Apache Camel Introduction Background Message-Oriented Middleware (MOM) Enterprise Integration Patterns Apache Camel Health Information Policy Implementing Information Policy Routing Based on Medical Context Enriching Messages with Medical Context Test Scenario Conclusions References A Personal Health Record System for Emergency Case Management Introduction Related Work Motivating Scenario System Architecture Security Architecture Access Control Policies Context Information Management Implementation Issues Concluding Remarks References A Method for Representing and Querying Temporal Information in OWL Introduction Background Temporal Model Temporal Querying Basic Temporal Queries: Allen’s Operators More Advanced Temporal Queries: Grouping and Aggregation More Advanced Temporal Queries: Temporal Collections Conclusions References Designing a Telemedical System for Cardiac Exercise Rehabilitation Introduction Rehabilitation after Cardiac Events User Centered Design of Telemedicine Applications Technical Requirements of Telemedicine Applications Related Work Background: OSAmI-D A User Study Interview Lead through The Current Setting Results User Interface Design Mockups Conclusions References A Value and Model Driven Method for Patient Oriented KPI Design in Health Care Introduction Related Work Method for Value Based KPI Identification Task 1: Develop Value Model Task 2: Generate Technical KPIs Task 3: Generate Functional KPIs Method Application Concluding Remarks References Part II Biomedical Electronics and Devices Encapsulated Multi-vesicle Assemblies of Programmable Architecture: Towards Personalized Healthcare Introduction Material and Methods Results Discussion Encapsulation Compartmentalization Composition Control Conclusions References Adaptive RBF-HMM Bi-Stage Classifier Applied to Brain Computer Interface Introduction Experimental Procedure Flow of Activities in the Experimental Process Electrode Position Description of Cognitive Activities Description of the Classifier Introduction Preprocessing Training of the Neural Network Description of Hidden Markov Models Training of the Hidden Markov Models Results Evaluation of the Learning Capability Evaluation of the Generalisation Capability Discussion Conclusions References Thermal Characteristics of Microcantilever Biosensors Introduction Theory and Numerical Analysis Numerical Analysis Results and Discussion Conclusions References Prosodic Speech Restoration Device: Glottal Excitation Restoration Using a Multi-resolution Approach Introduction Speech Rehabilitation for Alaryngeal Speakers Characteristics of Pathological Speech Multi-resolution Voice Restoration Method Long-Term Pitch Estimation Middle-Term Pitch Restoration Short-Term Pitch Restoration Results Conclusions References An Investigation on ALD Thin Film Evanescent Waveguide Sensor for Biomedical Application Introduction Fabrication Buckling of Thin Film Front Side Fabrication Propagation Losses Free Standing Structure Free Standing Processing New Structure Definition Conclusions References Part III Bio-inspired Systems and Signal Processing Probabilistic Patient Monitoring with Multivariate, Multimodal Extreme Value Theory Introduction Existing Patient Monitors Intelligent Patient Monitoring Contributions in This Paper Classical Extreme Value Theory Redefining ``Extrema'' Density Estimation Method Introduction Detail of Method Novelty Score Assignment Validation on Simulated Data Application to Vital-sign Data Discussion Conclusions Future Work Downloadable Content References Weighted SVMs and Feature Relevance Assessment in Supervised Heart Beat Classification Introduction State of the Art Theoretical Background Weighted SVM Classifier Hermite Basis Functions Higher Order Statistics ECG Database and Preprocessing Feature Extraction Experiments and Results Feature Relevance Assessment Peformance Evaluation Conclusions References The Investigation and Clinical Significance of Resonance in the Heart Rate and Vascular Tone Baroreflexes Introduction 0.1 Hz Resonance in the CVS Prior Studies: 0.1 Hz Resonance in the CVS Caused by Respiration Study 1: 0.1 Hz Resonance in the CVS Caused by Rhythmical Muscle Tension Study 2: 0.1 Hz Resonance in the CVS Caused by Emotional Pictures Cues 0.03 Hz Resonance in the CVS Study 1: 0.03 Hz Resonance in the CVS Caused by Aversive Sound Study 2: 0.03 Hz Resonance in the CVS Caused by Negative Emotional Pictures Discussion Conclusions References Glottal Inverse Filtering of Speech Based on Homomorphic Prediction: A Cepstrum-Based Algorithm Not Requiring Prior Detection of Either Pitch or Glottal Closure Introduction Simulated Voice Signals Simulation Model Characteristics of Simulated Glottal Signals Inverse Filtering Algorithms Iterative Adaptive Inverse Filtering (IAIF) Homomorphic Prediction (HoP) Results Conclusions References Texture Discrimination with Artificial Whiskers in the Robot-Rat Psikharpax Introduction System Description Texture Discrimination Feature Extraction Fixed Head Experiment Mobile Robot Experimentation Discussion Conclusions References Heart Rate Variability and the Acceleration Plethysmogram Signals Measured at Rest Introduction Data Methodology Detection of a-Waves HRV Analysis Results Conclusions References Emotional Face Perception in Healthy Subjects and Parkinson's Disease: An Effective Connectivity Study Introduction Methods Effective Connectivity Analysis Results Discussion Conclusions References Biometric Authentication with Electroencephalograms: Evaluation of Its Suitability Using Visual Evoked Potentials Introduction Electroencephalograms Visual Evoked Potentials (VEPs) Related Work An EEG-Based Authentication System Using VEP Personal Classifiers Authentication Process Description of the Data Set Feature Array Extraction The Feature Classifier Experimentation Overall Evaluation Results Evaluation of Individual Classifiers Open Issue: Constancy Conclusions References Part IV Bioinformatics Reconstructing the Phylogenetic Relationships of the Cyclophyllidean Cestodes: A Case Study Using ITS2 rDNA and Sequence-Structure Alignment Introduction Materials and Methods Sequence Alignments and Molecular Phylogenetic Analysis Bayeasian Phylogenetic Analysis ITS2 Secondary Structure Prediction and Sequence Structure Alignment Footnotes Results Neighbour-Joining (NJ) and Maximum Parsimony (MP) Trees Bayesian Phylogeny Secondary Structure Analysis and GC Content Discussion Conclusions References ReHap: A Framework for Single Individual Haplotyping from Next-Generation Sequencing Data Introduction Functionalities Algorithms Supported Algorithms Evaluation Experiments Conclusions References Inference of Large Phylogenies Using Neighbour-Joining Introduction Methods The Neighbour-Joining Method RapidNJ Reducing the Memory Consumption of RapidNJ An I/O Algorithm for Building Very Large Trees Improving the Search Heuristic Experiments Experimental Setup Results and Discussion Conclusions References Prediction of Minimum Free Energy Structure for Simple Non-standard Pseudoknot Introduction Simple Non-standard Pseudoknots Problem Definition Prediction Algorithm Subregion in Simple Non-standard Pseudoknot Dynamic Programming Algorithm Conclusions References Intra- and Inter-Molecular Coevolution: The Case of HIV1 Protease and Reverse Transcriptase Introduction Materials and Methods Sequence Data Information Theoretical Measures on (Co-)evolution Results Comparing Intra- and Inter-Protein Co-evolution of Residues Co-evolution between Residues in the PR and the RT? Discussion and Summary References Structured Output Prediction of Novel Enzyme Function with Reaction Kernels Introduction Enzyme Function Prediction Annotation Transfer Approaches Machine Learning Approaches Structured Output Learning Joint Kernels Learning Task Preimage Problem Kernels for Chemical Reactions Kernels for Molecule Graphs Sum-of-Reactants Kernel Reactant-Matching Kernels Experiments Data Compared Methods Measure of Success Results Discussion and Future Work References A Parallel Algorithm for Counting Subgraphs in Complex Networks Introduction Preliminaries Network Terminology Subgraph Census Related Work Parallel Algorithms Core Sequential Unit Initial Parallel Approaches Adaptive Parallel Enumeration Results Conclusions References Efficient Searching for Motifs in DNA Sequences Using Position Weight Matrices Introduction Position Weight Matrices Algorithm Algorithm Performance Space Performance Time Performance Discussion References Author Index This book constitutes the thoroughly refereed post-conference proceedings of the 4th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2011, held in Rome, Italy, in January 2011. The 27 revised full papers presented together with one invited lecture were carefully reviewed and selected from a total of 538 submissions. The papers cover a wide range of topics and are organized in four general topical sections on biomedical electronics and devices; bioinformatics models, methods and algorithms; bio-inspired systems and signal processing; health informatics.