Biomedical Advances In Aging (gwumc Department Of Biochemistry And Molecular Biology Annual Spring Symposia)

The VIIIth Annual International Spring Symposium on Health Sciences held at the George Washington University School of Medicine in Washington, D.C., attracted over three hun­ dred fifty scientists from twenty-five countries. The leading scientific experts in the field reported on recent biomedical advances in aging. They provided an up-to-date account of the molecular, genetic, nutritional, and immunological mechanisms associated with the aging process and approaches to intervention and treatment of the major disorders associated with the aging process, including Alzheimer's disease. A unique aspect of this meeting was a concurrent one-day hearing of the U.S. Senate Sub-Committee on Aging, organized by the Alliance for Aging Research. The theme for the hearing was "Advances in Aging Research." Seven scientists attending our aging sym­ posium were asked to testify. They were Drs. Carl Cotman (University of California-Irvine), Trudy Bush (Johns Hopkins University), Takashi Makinodan (University of California-Los Angeles), William Ershler (University of Wisconsin-Madison), Gino Doria (ENEA, Rome), Mr. Dan Perry (Director of the Alliance for Aging Research), and myself. Front Matter....Pages i-xi Front Matter....Pages 1-1 Brain Amyloidoses....Pages 3-24 Prions Causing Neurodegenerative Diseases....Pages 25-37 The Molecular Genetics of Alzheimer’s Disease....Pages 39-42 A Developmental Genetic Approach to the Analysis of Aging Processes....Pages 43-49 Alzheimer’s Disease....Pages 51-62 Evidence for the Molecular Basis of Aging and Sequestration of Mammalian Erythrocytes....Pages 63-73 α 1 á-Antichymotrypsin....Pages 75-88 Replication of Adenovirus 2 and Adeno-Associated Virus 2 in Young and Senescent Human Diploid Fibroblasts....Pages 89-107 Lactoferrin Immunoreactivity and Binding Sites in Neurons, Neuritic Plaques, and Neurofibrillary Tangles in Alzheimer’s Disease....Pages 109-124 Immunological Investigation of Thymic-Dependent Immunity in Normal Aging and in Patients with Senile Dementia of Alzheimer Type....Pages 125-133 Front Matter....Pages 135-135 Chronic Diseases and Disorders....Pages 137-142 Changes in Receptors and Signal Transduction Events during Aging....Pages 143-146 Molecular Aging of Membrane Molecules and Cellular Removal....Pages 147-161 Health Watch: A Longitudinal Prospective Study of Healthy Aging in 2200 Individuals....Pages 163-172 Plasma α-Tocopherol Levels in Men and Women of Different Ages....Pages 173-179 Polyenoic Fatty Acid Metabolism and Prostaglandin Biosynthesis in Aged Persons....Pages 181-185 Altered Phosphatidylinositol Breakdown in Polymorphonuclear Leukocytes with Aging....Pages 187-194 Rejoining of X-Ray-Induced DNA Double-Strand Breaks Declines in Unstimulated Human Lymphocytes Aging in Vivo ....Pages 195-206 Interventive Gerontology, Cloning, and Cryonics....Pages 207-220 Effects of Various Stimulators and Inhibitors on the Respiratory Burst of PMNL with Aging....Pages 221-228 Front Matter....Pages 135-135 Quantitative Approaches to Pathogenesis of Age-Related Metabolic Conditions....Pages 229-245 Front Matter....Pages 247-247 Nutritional Requirements in Aging....Pages 249-257 Influence of Dietary Restriction and Aging on Gene Expression in the Immune System of Rats....Pages 259-270 Zinc, Immunity, and Aging....Pages 271-281 Neuroendocrine Effects of Lifelong Dietary Restriction by Intermittent Feeding in Mice....Pages 283-290 Age-Associated Decline in Renal Response to Vasopressin....Pages 291-296 Obesity and Lipoproteins....Pages 297-302 Phenotype and Function of Lymphocyte Clones from Old and Young Subjects....Pages 303-311 Caloric Restriction and Longevity....Pages 313-317 Effect of Dietary Linolenate on the Pathogenesis of Fever....Pages 319-329 Poor Early Growth and Adult Mental and Somatic Health....Pages 331-346 Front Matter....Pages 347-347 Alterations in B Cells and Antibodies of Aged Mice....Pages 349-353 Molecular Genetic Analysis of Human Monoclonal Gammopathies....Pages 355-362 Developmental Aspects of T Lymphocytes in Aging....Pages 363-373 Role of the Thymus in Aging of the Immune System....Pages 375-384 Modulation of T-Cell Functions in Aging....Pages 385-390 Age-Related Decline in Immunological Resistance to Infection....Pages 391-400 The Clinical Significance of Immune Senescence....Pages 401-403 Immunosenescence and Human NK Cells....Pages 405-412 Regulation of the Expressed Idiotypic Repertoire in the Normal Immune Response of the Aged....Pages 413-424 Front Matter....Pages 347-347 Analysis of the Ability of Spleen Cells from Aged Mice to Produce Allospecific Cytotoxic Cells....Pages 425-432 Front Matter....Pages 433-433 Neuronal Populations in Normal and Abnormal Aging....Pages 435-440 An Optimistic View of the Aging Brain....Pages 441-449 Complex Maze Learning in Rodents....Pages 451-467 Age-Related Changes in Brain Protein Kinase C and Serotonin Release....Pages 469-476 Increased Blood Flow Augments CNS Axon Regeneration....Pages 477-484 Free and Bound Polyamines in Normal and Alzheimer Temporal Cortex....Pages 485-490 Neurochemical and Behavioral Effects of Bilateral Nucleus Basalis Lesions in the Aged Rat....Pages 491-496 Dopaminergic Neurons in the Substantia Nigra in Normal Aging and MPTP-Lesioned Mice....Pages 497-500 Synaptic Plasticity and Aging....Pages 501-510 Front Matter....Pages 511-511 Influenza and Aging....Pages 513-521 Age-Dependent Enhancement of Influenza Vaccine Responses by Thymosin in Chronic Hemodialysis Patients....Pages 523-530 Lipid and Lipoprotein Changes Due to Estrogen Replacement Therapies and Their Association with Prevention of Cardiovascular Disease in Postmenopausal Women....Pages 531-536 Immunopotentiating Activity of Thymopentin Treatment in Elderly Subjects....Pages 537-550 Thymopentin Therapy in Elderly Patients with Chronic Bronchitis....Pages 551-559 Aspirin and Risks of Cardiovascular Disease in the Physicians’ Health Study....Pages 561-569 Back Matter....Pages 571-586