Biomaterials for Cancer Therapeutics: Diagnosis, Prevention and Therapy (Woodhead Publishing Series in Biomaterials)

Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease.The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction.This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials.* A complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer * Discusses the fundamentals of biomaterials for cancer therapeutics * Discusses synthetic vaccines, proteins and polymers for cancer therapeutics Content: Front matter , Pages i-iii Copyright , Page iv Contributor contact details , Pages xii-xv , K. Park, B.K. Lee, Y.H. Yun, K. Park, M. Sturek, R. Mrsny, D.L. Stirland, J.W. Nichols, T.A. Denison, Y.H. Bae, M. Fiore, B. Thomas, P. Dumy, O. Renaudet, H. Kamada, S.-I. Tsunoda, H.J. Lee, A.N. Koo, I.K. Kwon, S.C. Lee, et al. Woodhead Publishing Series in Biomaterials , Pages xvi-xx Preface , Pages xxi-xxiii , Kinam Park 1 - Introduction to biomaterials for cancer therapeutics , Pages 3-19 , B.K. Lee, Y.H. Yun, K. Park, M. Sturek 2 - Cancer cell biology , Pages 20-30 , R. Mrsny 3 - Targeted drug delivery for cancer therapy , Pages 31-56 , D.L. Stirland, J.W. Nichols, T.A. Denison, Y.H. Bae 4 - Chemical synthesis of carbohydrate-based vaccines against cancers , Pages 59-94 , M. Fiore, B. Thomas, P. Dumy, O. Renaudet 5 - Generating functional mutant proteins to create highly bioactive anticancer biopharmaceuticals , Pages 95-112 , H. Kamada, S.-I. Tsunoda 6 - Polymer therapeutics for treating cancer , Pages 113-133 , H.J. Lee, A.N. Koo, I.K. Kwon, S.C. Lee 7 - Nanotechnology for cancer screening and diagnosis , Pages 137-164 , R. Zeineldin 8 - Synergistically integrated nanomaterials for multimodal cancer cell imaging , Pages 165-187 , X. Sun, X. Chen 9 - Hybrid nanocrystal as a versatile platform for cancer theranostics , Pages 188-206,207e , C.P. Hollis, R. Zhao, T. Li 10 - Embolisation devices from biomedical polymers for intra-arterial occlusion and drug delivery in the treatment of cancer , Pages 207-236,237e-239e , A.L. Lewis 11 - Small interfering RNAs (siRNAs) as cancer therapeutics , Pages 237-269 , G. Shim, M-G. Kim, J.Y. Park, Y-K. Oh 12 - Reverse engineering of the low temperature-sensitive liposome (LTSL) for treating cancer , Pages 270-348,349e-353e , D. Needham 13 - Gold nanoparticles (GNPs) as multifunctional materials for cancer treatment , Pages 349-386,387e-389e , A. Wei, M. Thomas, J. Mehtala, J. Wang 14 - Multifunctional nanosystems for cancer therapy , Pages 387-413 , A. Singh, A.K. Iyer, M. Amiji, S. Ganta 15 - Biomaterial strategies to modulate cancer , Pages 417-444 , K.M. McNeeley, J.G. Lyon, R. Bellamkonda 16 - 3D cancer tumor models for evaluating chemotherapeutic efficacy , Pages 445-460 , C.S. Shin, B. Kwak, B. Han, K. Park, A. Panitch 17 - Nanotopography of biomaterials for controlling cancer cell function , Pages 461-487,488e , L. Zhang, T. Webster Index , Pages 488-505 Drug delivery systems represent a vast area of research and development within biomaterials and medicine and the demand for sophisticated drug delivery devices continues to drive novel product development. Advanced drug delivery devices can offer significant advantages over conventional drugs and devices alone, such as increased efficiency, improved performance and convenience. The purpose of this book is to illustrate how effective drug delivery can be achieved by means other than tablets. The book will provide a thorough analysis of the fundamentals, applications and new technologies of drug-device combination products for use throughout the human body.

Part one provides readers with an introduction and background to the field. Chapters in Part two discuss areas of application such as catheter based products, drug eluting stents and beads and anti-biotic loaded cements. Part three covers the development of drug device combination products with chapters on such topics as pre-clinical testing, sterilisation, patent issues and regulation of drug device combination products.

With its distinguished editor and team of international contributors, Drug-device combination products: delivery technologies and applications is an invaluable reference for product development specialists, materials scientists and engineers in the biomedical industry and academia as well as those concerned with drug delivery.

• Illustrates how effective drug delivery can be achieved by means other than tablets providing readers with a comprehensive introduction and background to the field
• Provides a thorough analysis of the fundamentals, applications and new technologies of drug device combination products
• Discusses areas of application such as catheter based products and reviews the development of drug device combination products including pre-clinical testing and sterilisation

Hydrogels are very important for biomedical applications because they can be chemically manipulated to alter and control the hydrogel’s interaction with cells and tissues. Their flexibility and high water content is similar to that of natural tissue, making them extremely suitable for biomaterials applications. Biomedical hydrogels explores the diverse range and use of hydrogels, focusing on processing methods and novel applications in the field of implants and prostheses.

Part one of this book concentrates on the processing of hydrogels, covering hydrogel swelling behaviour, superabsorbent cellulose-based hydrogels and regulation of novel hydrogel products, as well as chapters focusing on the structure and properties of hydrogels and different fabrication technologies. Part two covers existing and novel applications of hydrogels, including chapters on spinal disc and cartilage replacement implants, hydrogels for ophthalmic prostheses and hydrogels for wound healing applications. The role of hydrogels in imaging implants in situ is also discussed.

With its distinguished editor and international team of contributors, Biomedical hydrogels is an excellent reference for biomedical research scientists and engineers in industry and academia, as well as others involved in research in this area, such as research clinicians.

• Examines the diverse range and use of hydrogels, focusing on processing methods and novel applications
• Comprehensive book explores the structure and properties of hydrogels and different fabrication technologies
• Covers important areas such as processing of hydrogels, covering hydrogel swelling behaviour, superabsorbent cellulose-based hydrogels and regulation of novel hydrogel products

Hydrogels are very important for biomedical applications because they can be chemically manipulated to alter and control the hydrogel's interaction with cells and tissues. Their flexibility and high water content is similar to that of natural tissue, making them extremely suitable for biomaterials applications. Biomedical hydrogels explores the diverse range and use of hydrogels, focusing on processing methods and novel applications in the field of implants and prostheses. Part one of this book concentrates on the processing of hydrogels, covering hydrogel swelling behaviour, superabsorbent cellulose-based hydrogels and regulation of novel hydrogel products, as well as chapters focusing on the structure and properties of hydrogels and different fabrication technologies. Part two covers existing and novel applications of hydrogels, including chapters on spinal disc and cartilage replacement implants, hydrogels for ophthalmic prostheses and hydrogels for wound healing applications. The role of hydrogels in imaging implants in situ is also discussed. With its distinguished editor and international team of contributors, Biomedical hydrogels is an excellent reference for biomedical research scientists and engineers in industry and academia, as well as others involved in research in this area, such as research clinicians.Examines the diverse range and use of hydrogels, focusing on processing methods and novel applicationsComprehensive book explores the structure and properties of hydrogels and different fabrication technologiesCovers important areas such as processing of hydrogels, covering hydrogel swelling behaviour, superabsorbent cellulose-based hydrogels and regulation of novel hydrogel products Nanotechnology is at the forefront of advances in medicine. Nanomedicine: Technologies and applications provides an important review of this exciting technology and its growing range of applications.

After an introduction to nanomedicine, part one discusses key materials and their properties, including nanocrystalline metals and alloys, nanoporous gold and hydroxyapatite coatings. Part two goes on to review nanomedicine for therapeutics and imaging, before nanomedicine for soft tissue engineering is discussed in part three, including organ regeneration, skin grafts, nanotubes and self-assembled nanomaterials. Finally, nanomedicine for bone and cartilage tissue engineering is the focus of part four, with electrically active biocomposites as smart scaffolds investigated, as is cartilage and bone tissue engineering, regeneration and replacement.

With its distinguished editor and international team of expert contributors, Nanomedicine: Technologies and applications is an indispensable guide for all those involved in the research, development and application of this exciting technology, whilst providing a comprehensive introduction for students and academics interested in this field.

• Provides an important review of nanomedicine technology and its growing range of applications
• Discusses key nanomedicine materials and their properties, including nanocrystalline metals and alloys, nanoporous gold and hydroxyapatite coatings
• Reviews nanomedicine for therapeutics and imaging and nanomedicine for soft tissue engineering

Nanotechnology is at the forefront of advances in medicine. Nanomedicine: Technologies and applications provides an important review of this exciting technology and its growing range of applications. After an introduction to nanomedicine, part one discusses key materials and their properties, including nanocrystalline metals and alloys, nanoporous gold and hydroxyapatite coatings. Part two goes on to review nanomedicine for therapeutics and imaging, before nanomedicine for soft tissue engineering is discussed in part three, including organ regeneration, skin grafts, nanotubes and self-assembled nanomaterials. Finally, nanomedicine for bone and cartilage tissue engineering is the focus of part four, with electrically active biocomposites as smart scaffolds investigated, as is cartilage and bone tissue engineering, regeneration and replacement. With its distinguished editor and international team of expert contributors, Nanomedicine: Technologies and applications is an indispensable guide for all those involved in the research, development and application of this exciting technology, whilst providing a comprehensive introduction for students and academics interested in this field. Provides an important review of nanomedicine technology and its growing range of applicationsDiscusses key nanomedicine materials and their properties, including nanocrystalline metals and alloys, nanoporous gold and hydroxyapatite coatingsReviews nanomedicine for therapeutics and imaging and nanomedicine for soft tissue engineering Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease.

The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction.

This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials.

• A complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer
• Discusses the fundamentals of biomaterials for cancer therapeutics
• Discusses synthetic vaccines, proteins and polymers for cancer therapeutics

Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction. This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials. A complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer Discusses the fundamentals of biomaterials for cancer therapeutics Discusses synthetic vaccines, proteins and polymers for cancer therapeutics Annotation Drug delivery systems represent a vast area of research and development within biomaterials and medicine and the demand for sophisticated drug delivery devices continues to drive developments. Advanced drug delivery devices can offer significant advantages to conventional drugs, such as increased efficiency and convenience. Chapters in part one discuss specific applications such as drug eluting stents and antimicrobial cements. Part two covers the development of drug device combination products with such topics as preclinical testing and regulation of products. This book will provide a thorough analysis of the fundamentals, applications and new technologies of drug-device combination products for use throughout the human body With its distinguished editor and international team of contributors, this an excellent reference for biomedical research scientists and engineers in industry and academia, as well as others involved in research in this area, such as research clinicians. It examines the diverse range and use of hydrogels, focusing on processing methods and novel applications; explores the structure and properties of hydrogels and different fabrication technologies; covers important areas such as processing of hydrogels, covering hydrogel swelling behaviour, superabsorbent cellulose-based hydrogels and regulation of novel hydrogel products. -- Edited summary from book This book provides an overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. It discusses synthetic vaccines, proteins, and polymers for cancer therapeutics, theranosis and drug delivery systems, and biomaterial therapies and cancer cell interaction Numerous potential new therapeutics are being researched by many different institutions and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential Biomaterials have to treat this prevalent disease. Due to their significant water content, hydrogels possess a degree of flexibility similar to natural tissue. This book explores the diverse range and use of hydrogels, focusing on processing methods and novel applications. This book reviews the current status of this exciting technology and will provide readers with comprehensive information on the properties and applications of the technology.