Biomarkers: Research And Application In The Assessment Of Environmental Health (nato Asi Subseries H:)

Biological markers used to assess the effects of environmental pollution have attracted considerable attention from regulatory agencies and are currently under evaluation at a number of research facilities throughout the world. However promising a biomarker-based biomonitoring approach may be, the development of this concept is complicated by a range of technical issues. This book provides a conceptional framework for research and application of biomarkers. International experts on biomonitoring have formulated a unified strategy for the development and validation of biomarkers in assessing environmental health as well as appropriate protocols for their implementation and interpretation in a biological monitoring program. Front Matter....Pages I-XIX Applications and Objectives of Biomarker Research....Pages 1-13 The Conceptual Basis of the Biomarker Approach....Pages 15-29 Implementation of Biomarker-Based Studies....Pages 31-48 Interpretation of Biomarker Responses....Pages 49-61 Development and Validation of Biomarkers....Pages 63-77 Conceptual Strategy for Development and Application of a Biomarker-Based Biomonitoring Program....Pages 79-109 Back Matter....Pages 111-119 Proceedings of the NATO Advanced Research Workshop on Biological Markers held at Texel, Netherlands, May 12-17, 1991