Biomarkers : In Medicine, Drug Discovery, and Environmental Health

"This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson's, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process"--Provided by publisher. (Publisher-supplied data) 1 (Biomarkers: An Evolutionary Perspective (Michael Ferguson & Vishal Vaidya) 2 (Genomics (Weida Tong and Donna L. Mendrick) 3 (Proteomics for Biomarker Discovery (Timothy D. Veenstra) 4 (Metabolic Profiling for Biomarker Discovery (Hector C. Keun) 5 (The Bittersweet Promise of Glycobiology (Padmaparna Chaudhuri, Rania Harfouche, Shiladitya Sengupta) 6 (Biomarkers of Alzheimer?s and Parkinson?s Disease (Walter Maetzler, Daniela Berg) 7 (Biomarkers of Cardiac Injury (Anthony S. McLean and Stephen J. Huang) 8 (Lung Injury Biomarkers (Urmila P. Kodavanti) 9 (Translational Biomarkers of Acute Drug Induced Liver Injury: The Current State, Gaps and Future Opportunities (Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta and Shashi Ramaiah) 10 (Biomarkers of Acute Kidney Injury (Frank Dieterle and Frank Sistare) 11 (In Search of Biomarkers for Drug-induced Vascular Injury (James R. Turk) 12 (Biomarkers of Immunotoxicity (Rodney R. Dietert) 13 (Biomarkers in Obstetric Medicine (Manish Maski, Sarosh Rana and S. Ananth Karumanchi (NA (0) 14 (Biomarkers in Cancer (Roopali Roy, Christine M. Coticchia, Jiang Yang and Marsha A. Moses) 15 (Biomarkers of HIV (Lewis Kaufman and Michael J Ross ) 16 (Biomarkers of Drug-Induced Mitochondrial Dysfunction (James Dykens and Yvonne Will) 17 (Immunoassay-based technologies for the measurement of biological materials used for biomarkers discovery and translational research (Vincent Ricchiuti ) 18 (Nanoscale Techniques for Biomarker Quantification (Madhukar Varshney, Harold G. Craighead) 19 (Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices (Roy R. Mondesire, Glen M. Ford, Hannie F. Ford, Stephen C. Mefferd) 20 (Regulatory perspective for biomarker qualification from US-FDA (Federico Goodsaid) 21 (The European Medicines Agency approach (Marisa Papaluca-Amati and Spiros Vamvakas) 22 (Biomarkers for Environmental Exposure (Jane E. Gallagher, Elaine A. Cohen Hubal and Stephen W. Edwards) 23 (Clinical Study Design in Biomarker Research (Orfeas Liangos & Bertrand L. Jaber) 24 (Statistical Issues in Biomarker Research (Daniel Holder and Matthew Schipper). Biomarkers can predict a patient's response to a compound, act as a surrogate endpoint, and aid in making efficacious and cost-saving decisions for terminating drug entities more quickly during the research process. This book looks at the principles, advantages, disadvantages, and applications of methods for biomarker discovery techniques.