Biomanufacturing

Advances in bioproducts manufacturing such as the production of the anticancer drug paclitaxel by large-scale plant cell culture, submerged cultivation of medicinal mushrooms, and monoclonal antibody production are reflected. Interactions among molecular, cellular and process engineering aspects in industrial fermentations are discussed, and application of fuzzy control and fuzzy neural networks to practical production and the biomedical area are shown. For sustainable development and green processing, production of lactic acid from paper sludge, production of a generic fermentation feedstock from wheat, and fabrication and application of whole-cell based biosensors in the environment are also demonstrated. 1 H. Tabata: Paclitaxel Production by Plant Cell Culture Technology.-2 J.J. Zhong, Y.-J. Tang: Submerged Cultivation of Medicinal Mushrooms for Production of Valuable Bioactive Metabolites.-3 S.-T. Yang, J.Luo, C. Chen: A Fibrous-Bed Bioreactor for Continuous Production of Monoclonal Antibody by Hybridoma.-4 S. Zhang, J. chu, Y. Zhuang:A Multi-Scale Study on Industrial Fermentation Processes and Their Optimization.-5 H. Honda, T. Kobayashi: Industrial Application of Fuzzy Control in Bioprocess.- 6 S.-M. Lee, J. Lin, Y.-M. Koo: Production of Lactic Acid from Paper Sludge Using Simultaneous Saccharification and Fermentation.- 7 C. Webb, A.A. Koutinas, R. Wang: Developing a Sustainable Bioprocessing Strategy Based on a Generic Feedstock.- 8 M.B. Gu, R.J. Mitchell, B.C. Kim: Whole Cell-Based Biosensors for Environmental Biomonitoring and Application.- Paclitaxel Production by Plant-Cell-Culture Technology....Pages 1-23 Submerged Cultivation of Medicinal Mushrooms for Production of Valuable Bioactive Metabolites....Pages 25-59 A Fibrous-Bed Bioreactor for Continuous Production of Monoclonal Antibody by Hybridoma....Pages 61-96 A Multi-Scale Study of Industrial Fermentation Processes and Their Optimization....Pages 97-150 Industrial Application of Fuzzy Control in Bioprocesses....Pages 151-171 Production of Lactic Acid from Paper Sludge by Simultaneous Saccharification and Fermentation....Pages 173-194 Developing a Sustainable Bioprocessing Strategy Based on a Generic Feedstock....Pages 195-268 Whole-Cell-Based Biosensors for Environmental Biomonitoring and Application....Pages 269-305 In this volume, J.-J. Zhong covers trends in modern biotechnology